Search Results - "Berwanger, Carolin"

Clinorotation inhibits myotube formation by fluid motion, not by simulated microgravity by Mansour, Janet, Berwanger, Carolin, Jung, Marcel, Eichinger, Ludwig, Fabry, Ben, Clemen, Christoph S.

“…To study processes related to weightlessness in ground-based cell biological research, a theoretically assumed microgravity environment is typically simulated…”
Get full text

Mutant desmin substantially perturbs mitochondrial morphology, function and maintenance in skeletal muscle tissue by Winter, Lilli, Wittig, Ilka, Peeva, Viktoriya, Eggers, Britta, Heidler, Juliana, Chevessier, Frederic, Kley, Rudolf A., Barkovits, Katalin, Strecker, Valentina, Berwanger, Carolin, Herrmann, Harald, Marcus, Katrin, Kornblum, Cornelia, Kunz, Wolfram S., Schröder, Rolf, Clemen, Christoph S.

“…Secondary mitochondrial dysfunction is a feature in a wide variety of human protein aggregate diseases caused by mutations in different proteins, both in the…”
Get full text

Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria by Berwanger, Carolin, Terres, Dominic, Pesta, Dominik, Eggers, Britta, Marcus, Katrin, Wittig, Ilka, Wiesner, Rudolf J., Schröder, Rolf, Clemen, Christoph S.

“…Desmin gene mutations cause myopathies and cardiomyopathies. Our previously characterised R349P desminopathy mice, which carry the ortholog of the common human…”
Get full text

Desmin Knock-Out Cardiomyopathy: A Heart on the Verge of Metabolic Crisis by Elsnicova, Barbara, Hornikova, Daniela, Tibenska, Veronika, Kolar, David, Tlapakova, Tereza, Schmid, Benjamin, Mallek, Markus, Eggers, Britta, Schlötzer-Schrehardt, Ursula, Peeva, Viktoriya, Berwanger, Carolin, Eberhard, Bettina, Durmuş, Hacer, Schultheis, Dorothea, Holtzhausen, Christian, Schork, Karin, Marcus, Katrin, Jordan, Jens, Lücke, Thomas, van der Ven, Peter F. M., Schröder, Rolf, Clemen, Christoph S., Zurmanova, Jitka M.

“…Desmin mutations cause familial and sporadic cardiomyopathies. In addition to perturbing the contractile apparatus, both desmin deficiency and mutated desmin…”
Get full text

Heart failure after pressure overload in autosomal-dominant desminopathies: Lessons from heterozygous DES-p.R349P knock-in mice by Stöckigt, Florian, Eichhorn, Lars, Beiert, Thomas, Knappe, Vincent, Radecke, Tobias, Steinmetz, Martin, Nickenig, Georg, Peeva, Viktoriya, Kudin, Alexei P, Kunz, Wolfram S, Berwanger, Carolin, Kamm, Lisa, Schultheis, Dorothea, Schlötzer-Schrehardt, Ursula, Clemen, Christoph S, Schröder, Rolf, Schrickel, Jan W

“…Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardiomyopathies, leading to heart failure, arrhythmias, and AV blocks. We…”
Get full text

An Intronic Heterozygous SYNE2 Splice Site Mutation: A Rare Cause for Myalgia and hyperCKemia? by Paulus, Theresa, Young, Natalie, Jessop, Emily, Berwanger, Carolin, Clemen, Christoph Stephan, Schröder, Rolf, Ploski, Rafal, Hagel, Christian, Hellenbroich, Yorck, Moser, Andreas, Karakesisoglou, Iakowos

“…SYNE2 mutations have been associated with skeletal and cardiac muscle diseases, including Emery-Dreifuss muscular dystrophy (EDMD). Here, we present a…”
Get full text

Coronin 1C-free primary mouse fibroblasts exhibit robust rearrangements in the orientation of actin filaments, microtubules and intermediate filaments by Behrens, Juliane, Solga, Roxana, Ziemann, Anja, Rastetter, Raphael H., Berwanger, Carolin, Herrmann, Harald, Noegel, Angelika A., Clemen, Christoph S.

“…Coronin 1C is an established modulator of actin cytoskeleton dynamics. It has been shown to be involved in protrusion formation, cell migration and invasion…”
Get full text

Dual Functional States of R406W-Desmin Assembly Complexes Cause Cardiomyopathy With Severe Intercalated Disc Derangement in Humans and in Knock-In Mice by Herrmann, Harald, Cabet, Eva, Chevalier, Nicolas R., Moosmann, Julia, Schultheis, Dorothea, Haas, Jan, Schowalter, Mirjam, Berwanger, Carolin, Weyerer, Veronika, Agaimy, Abbas, Meder, Benjamin, Müller, Oliver J., Katus, Hugo A., Schlötzer-Schrehardt, Ursula, Vicart, Patrick, Ferreiro, Ana, Dittrich, Sven, Clemen, Christoph S., Lilienbaum, Alain, Schröder, Rolf

“…BACKGROUND:Mutations in the human desmin gene cause myopathies and cardiomyopathies. This study aimed to elucidate molecular mechanisms initiated by the…”
Get full text

Effects of long‐term immobilisation on endomysium of the soleus muscle in humans by Thot, Georgina K., Berwanger, Carolin, Mulder, Edwin, Lee, Jessica K., Lichterfeld, Yannick, Ganse, Bergita, Giakoumaki, Ifigeneia, Degens, Hans, Duran, Ibrahim, Schönau, Eckhard, Clemen, Christoph S., Brachvogel, Bent, Rittweger, Jörn

“…New Findings What is the central question of this study? While muscle fibre atrophy in response to immobilisation has been extensively examined, intramuscular…”
Get full text

N471D WASH complex subunit strumpellin knock‐in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue by Clemen, Christoph S., Schmidt, Andreas, Winter, Lilli, Canneva, Fabio, Wittig, Ilka, Becker, Lore, Coras, Roland, Berwanger, Carolin, Hofmann, Andreas, Eggers, Britta, Marcus, Katrin, Gailus‐Durner, Valerie, Fuchs, Helmut, Angelis, Martin Hrabe, Krüger, Marcus, Hörsten, Stephan, Eichinger, Ludwig, Schröder, Rolf

“…Aims We investigated N471D WASH complex subunit strumpellin (Washc5) knock‐in and Washc5 knock‐out mice as models for hereditary spastic paraplegia type 8…”
Get full text

The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice? by Clemen, Christoph S., Winter, Lilli, Strucksberg, Karl-Heinz, Berwanger, Carolin, Türk, Matthias, Kornblum, Cornelia, Florin, Alexandra, Aguilar-Pimentel, Juan Antonio, Amarie, Oana Veronica, Becker, Lore, Garrett, Lillian, Hans, Wolfgang, Moreth, Kristin, Neff, Frauke, Pingen, Laura, Rathkolb, Birgit, Rácz, Ildikó, Rozman, Jan, Treise, Irina, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabe, Vorgerd, Matthias, Eichinger, Ludwig, Schröder, Rolf

“…Heterozygous missense mutations in the human VCP gene cause inclusion body myopathy associated with Paget disease of bone and fronto-temporal dementia (IBMPFD)…”
Get full text

CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells by Solga, Roxana, Behrens, Juliane, Ziemann, Anja, Riou, Adrien, Berwanger, Carolin, Becker, Lore, Garrett, Lillian, de Angelis, Martin Hrabe, Fischer, Lisa, Coras, Roland, Barkovits, Katalin, Marcus, Katrin, Mahabir, Esther, Eichinger, Ludwig, Schröder, Rolf, Noegel, Angelika A., Clemen, Christoph S.

“…•CRN2 knock-out mice display neurological and behavioural alterations.•glioblastoma cells overexpressing CRN2 more effectively encase capillaries.•CRN2…”
Get full text

Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients by Türk, Matthias, Schröder, Rolf, Khuller, Katharina, Hofmann, Andreas, Berwanger, Carolin, Ludolph, Albert C, Dekomien, Gabriele, Müller, Kathrin, Weishaupt, Jochen H, Thiel, Christian T, Clemen, Christoph S

“…Abstract Mutations of the human valosin-containing protein, p97 (VCP) and Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex genes cause motor…”
Get full text