Search Results - "Bertucci, F"

Basal breast cancer: a complex and deadly molecular subtype by Bertucci, F, Finetti, P, Birnbaum, D

“…During the last decade, gene expression profiling of breast cancer has revealed the existence of five molecular subtypes and allowed the establishment of a new…”
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Outcome and molecular landscape of patients with PIK3CA-mutated metastatic breast cancer by Mosele, F., Stefanovska, B., Lusque, A., Tran Dien, A., Garberis, I., Droin, N., Le Tourneau, C., Sablin, M.-P., Lacroix, L., Enrico, D., Miran, I., Jovelet, C., Bièche, I., Soria, J.-C., Bertucci, F., Bonnefoi, H., Campone, M., Dalenc, F., Bachelot, T., Jacquet, A., Jimenez, M., André, F.

“…α-Selective phosphatidylinositol 3-kinase (PI3K) inhibitors improve outcome in patients with PIK3CA-mutated, hormone receptor-positive (HR+)/Her2− metastatic…”
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Management and prognosis of malignant peripheral nerve sheath tumors: The experience of the French Sarcoma Group (GSF-GETO) by Valentin, T, Le Cesne, A, Ray-Coquard, I, Italiano, A, Decanter, G, Bompas, E, Isambert, N, Thariat, J, Linassier, C, Bertucci, F, Bay, J.O, Bellesoeur, A, Penel, N, Le Guellec, S, Filleron, T, Chevreau, C

“…Abstract Background Malignant peripheral nerve sheath tumors (MPNST) are a rare subtype of soft tissue sarcoma. They can arise in irradiated fields, in…”
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Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer by M-Rabet, M., Cabaud, O., Josselin, E., Finetti, P., Castellano, R., Farina, A., Agavnian-Couquiaud, E., Saviane, G., Collette, Y., Viens, P., Gonçalves, A., Ginestier, C., Charafe-Jauffret, E., Birnbaum, D., Olive, D., Bertucci, F., Lopez, M.

“…Triple-negative breast cancers (TNBCs) are associated with a poor prognosis. In contrast to other molecular subtypes, they have no identified specific target…”
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Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort by Italiano, A., Bessede, A., Pulido, M., Bompas, E., Piperno-Neumann, S., Chevreau, C., Penel, N., Bertucci, F., Toulmonde, M., Bellera, C., Guegan, J. P., Rey, C., Sautès-Fridman, C., Bougoüin, A., Cantarel, C., Kind, M., Spalato, M., Dadone-Montaudie, B., Le Loarer, F., Blay, J. Y., Fridman, W. H.

“…Immune checkpoint inhibitors (ICIs) show limited clinical activity in patients with advanced soft-tissue sarcomas (STSs). Retrospective analysis suggests that…”
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Infiltrating stromal immune cells in inflammatory breast cancer are associated with an improved outcome and increased PD-L1 expression by Van Berckelaer, C, Rypens, C, van Dam, P, Pouillon, L, Parizel, M, Schats, K A, Kockx, M, Tjalma, W A A, Vermeulen, P, van Laere, S, Bertucci, F, Colpaert, C, Dirix, L

“…Inflammatory breast cancer (IBC) is a rare and rapidly progressive form of invasive breast cancer. The aim of this study was to explore the clinical evolution,…”
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Programmed cell death 1 (PD-1) targeting in patients with advanced osteosarcomas: results from the PEMBROSARC study by Le Cesne, A., Marec-Berard, P., Blay, J.-Y., Gaspar, N., Bertucci, F., Penel, N., Bompas, E., Cousin, S., Toulmonde, M., Bessede, A., Fridman, W.H., Sautes-Fridman, C., Kind, M., Le Loarer, F., Pulido, M., Italiano, A.

“…There are some lines of evidence suggesting a potential role of immunotherapy for treating patients with osteosarcomas. This was an open-label, multicentre,…”
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Surgery in reference centers improves survival of sarcoma patients: a nationwide study by Blay, J.-Y., Honoré, C., Stoeckle, E., Meeus, P., Jafari, M., Gouin, F., Anract, P., Ferron, G., Rochwerger, A., Ropars, M., Carrere, S., Marchal, F., Sirveaux, F., Di Marco, A., Le Nail, L.R., Guiramand, J., Vaz, G., Machiavello, J.-C., Marco, O., Causeret, S., Gimbergues, P., Fiorenza, F., Chaigneau, L., Guillemin, F., Guilloit, J.-M., Dujardin, F., Spano, J.-P., Ruzic, J.-C., Michot, A., Soibinet, P., Bompas, E., Chevreau, C., Duffaud, F., Rios, M., Perrin, C., Firmin, N., Bertucci, F., Le Pechoux, C., Le Loarer, F., Collard, O., Karanian-Philippe, M., Brahmi, M., Dufresne, A., Dupré, A., Ducimetière, F., Giraud, A., Pérol, D., Toulmonde, M., Ray-Coquard, I., Italiano, A., Le Cesne, A., Penel, N., Bonvalot, S.

“…NETSARC (netsarc.org) is a network of 26 sarcoma reference centers with specialized multidisciplinary tumor boards (MDTB) aiming to improve the outcome of…”
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A refined molecular taxonomy of breast cancer by Guedj, M, Marisa, L, de Reynies, A, Orsetti, B, Schiappa, R, Bibeau, F, MacGrogan, G, Lerebours, F, Finetti, P, Longy, M, Bertheau, P, Bertrand, F, Bonnet, F, Martin, A L, Feugeas, J P, Bièche, I, Lehmann-Che, J, Lidereau, R, Birnbaum, D, Bertucci, F, de Thé, H, Theillet, C

“…The current histoclinical breast cancer classification is simple but imprecise. Several molecular classifications of breast cancers based on expression…”
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Gene expression profiling of breast cell lines identifies potential new basal markers by CHARAFE-JAUFFRET, E, GINESTIER, C, BERTUCCI, F, MONVILLE, F, FINETTI, P, ADELAÏDE, J, CERVERA, N, FEKAIRI, S, XERRI, L, JACQUEMIER, J, BIRNBAUM, D

“…A better molecular characterization of breast cell lines (BCL) may help discover new markers to apply to tumour samples. We performed gene and protein…”
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Pathological grade-independent prediction of chemosensitivity by CINSARC should rehabilitate adjuvant chemotherapy in soft tissue sarcomas of any grade by Bertucci, F., Finetti, P., Monneur, A., Birnbaum, D.

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The role of intestinal microbiota and the immune system by Purchiaroni, F, Tortora, A, Gabrielli, M, Bertucci, F, Gigante, G, Ianiro, G, Ojetti, V, Scarpellini, E, Gasbarrini, A

“…The human gut is an ecosystem consisting of a great number of commensal bacteria living in symbiosis with the host. Several data confirm that gut microbiota is…”
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Advanced chondrosarcomas: role of chemotherapy and survival by Italiano, A., Mir, O., Cioffi, A., Palmerini, E., Piperno-Neumann, S., Perrin, C., Chaigneau, L., Penel, N., Duffaud, F., Kurtz, J.E., Collard, O., Bertucci, F., Bompas, E., Le Cesne, A., Maki, R.G., Ray Coquard, I., Blay, J.Y.

“…There are limited data about the role of chemotherapy in patients with advanced chondrosarcomas. The medical charts of 180 patients with advanced…”
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Abdominal desmoplastic small round cell tumor without extraperitoneal metastases: Is there a benefit for HIPEC after macroscopically complete cytoreductive surgery? by Honoré, C, Atallah, V, Mir, O, Orbach, D, Ferron, G, LePéchoux, C, Delhorme, J B, Philippe-Chomette, P, Sarnacki, S, Msika, S, Terrier, P, Glehen, O, Martelli, H, Minard-Colin, V, Bertucci, F, Blay, J Y, Bonvalot, S, Elias, D, LeCesne, A, Sargos, P

“…Desmoplastic Small Round Cell Tumor (DSRCT) is a rare disease affecting predominantly children and young adults and for which the benefit of hyperthermic…”
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Prediction of local and metastatic recurrence in solitary fibrous tumor: construction of a risk calculator in a multicenter cohort from the French Sarcoma Group (FSG) database by Salas, S., Resseguier, N., Blay, J.Y., Le Cesne, A., Italiano, A., Chevreau, C., Rosset, P., Isambert, N., Soulie, P., Cupissol, D., Delcambre, C., Bay, J.O., Dubray-Longeras, P., Krengli, M., De Bari, B., Villa, S., Kaanders, J.H.A.M., Torrente, S., Pasquier, D., Thariat, J.O., Myroslav, L., Sole, C.V., Dincbas, H.F., Habboush, J.Y., Zilli, T., Dragan, T., Khanfir, K., Ugurluer, G., Cena, T., Duffaud, F., Penel, N., Bertucci, F., Ranchere-Vince, D., Terrier, P., Bonvalot, S., Macagno, N., Lemoine, C., Lae, M., Coindre, J.M., Bouvier, C.

“…Solitary fibrous tumors (SFT) are rare unusual ubiquitous soft tissue tumors that are presumed to be of fibroblastic differentiation. At present, the challenge…”
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Sorafenib in patients with locally advanced and metastatic chordomas: a phase II trial of the French Sarcoma Group (GSF/GETO) by Bompas, E., Le Cesne, A., Tresch-Bruneel, E., Lebellec, L., Laurence, V., Collard, O., Saada-Bouzid, E., Isambert, N., Blay, J.Y., Amela, E.Y., Salas, S., Chevreau, C., Bertucci, F., Italiano, A., Clisant, S., Penel, N.

“…There is no consensual treatment of locally advanced or metastatic chordomas. We conducted a multicenter, open-label, uncontrolled phase II trial of sorafenib…”
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Metastatic angiosarcomas: doxorubicin-based regimens, weekly paclitaxel and metastasectomy significantly improve the outcome by Penel, N., Italiano, A., Ray-Coquard, I., Chaigneau, L., Delcambre, C., Robin, Y.M., Bui, B., Bertucci, F., Isambert, N., Cupissol, D., Bompas, E., Bay, J.O., Duffaud, F., Guillemet, C., Blay, J.Y.

“…Angiosarcomas are a rare but aggressive form of soft tissue sarcoma. At metastatic stage, the clinical benefit of therapeutic intervention remains debatable…”
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A randomized phase III trial comparing trabectedin to best supportive care in patients with pre-treated soft tissue sarcoma: T-SAR, a French Sarcoma Group trial by Le Cesne, A., Blay, J.-Y., Cupissol, D., Italiano, A., Delcambre, C., Penel, N., Isambert, N., Chevreau, C., Bompas, E., Bertucci, F., Chaigneau, L., Piperno-Neumann, S., Salas, S., Rios, M., Guillemet, C., Bay, J.-O., Ray-Coquard, I., Haddag, L., Bonastre, J., Kapso, R., Fraslin, A., Bouvet, N., Mir, O., Foulon, S.

“…The French Sarcoma Group assessed the efficacy, safety, and quality of life (QoL) of trabectedin versus best supportive care (BSC) in patients with advanced…”
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SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations by Takedachi, A., Despras, E., Scaglione, S., Guérois, R., Guervilly, J. H., Blin, M., Audebert, S., Camoin, L., Hasanova, Z., Schertzer, M., Guille, A., Churikov, D., Callebaut, I., Naim, V., Chaffanet, M., Borg, J. P., Bertucci, F., Revy, P., Birnbaum, D., Londoño-Vallejo, A., Kannouche, P. L., Gaillard, P. H. L.

“…The SLX4 tumor suppressor is a scaffold that plays a pivotal role in several aspects of genome protection, including homologous recombination, interstrand DNA…”
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Can we cure patients with abdominal Desmoplastic Small Round Cell Tumor? Results of a retrospective multicentric study on 100 patients by Honoré, C., Delhorme, J.B., Nassif, E., Faron, M., Ferron, G., Bompas, E., Glehen, O., Italiano, A., Bertucci, F., Orbach, D., Pocard, M., Quenet, F., Blay, J.Y., Carrere, S., Chevreau, C., Mir, O., Le Cesne, A.

“…Despite being associated with a very poor prognosis, long-term survivors across all series of Desmoplastic Small Round Cell Tumor (DSRCT) have been reported…”
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