Search Results - "Bertrand, Jeanluc"

New Inhibitors of Bcr-Abl Based on 2,6,9-Trisubstituted Purine Scaffold Elicit Cytotoxicity in Chronic Myeloid Leukemia-Derived Cell Lines Sensitive and Resistant to TKIs by Delgado, Thalia, Veselá, Denisa, Dostálová, Hana, Kryštof, Vladimír, Vojáčková, Veronika, Jorda, Radek, Castro, Alejandro, Bertrand, Jeanluc, Rivera, Gildardo, Faúndez, Mario, Strnad, Miroslav, Espinosa-Bustos, Christian, Salas, Cristian O

“…Bcr-Abl is an oncoprotein with aberrant tyrosine kinase activity involved in the progression of chronic myeloid leukemia (CML) and has been targeted by…”
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Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia by Bertrand, Jeanluc, Dostálová, Hana, Kryštof, Vladimír, Jorda, Radek, Delgado, Thalía, Castro-Alvarez, Alejandro, Mella, Jaime, Cabezas, David, Faúndez, Mario, Espinosa-Bustos, Christian, Salas, Cristian O.

“…We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine…”
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Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models by Ballesteros-Casallas, Andres, Quiroga, Cristina, Ortiz, Cecilia, Benítez, Diego, Denis, Pablo A., Figueroa, David, Salas, Cristian O., Bertrand, Jeanluc, Tapia, Ricardo A., Sánchez, Patricio, Miscione, Gian Pietro, Comini, Marcelo A., Paulino, Margot

“…Quinones are attractive pharmacological scaffolds for developing new agents for the treatment of different transmissible and non-transmissible human diseases…”
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Friedländer Synthesis of Novel Polycyclic Quinolines Using Solid SiO 2 /H 2 SO 4 Catalyst by Satheeshkumar, Rajendran, Shanmugaraj, Krishnamoorthy, Delgado, Thalia, Bertrand, Jeanluc, Brito, Iván, Salas, Cristian O.

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Friedländer Synthesis of Novel Polycyclic Quinolines Using Solid SiO2/H2SO4 Catalyst by Satheeshkumar, Rajendran, Shanmugaraj, Krishnamoorthy, Delgado, Thalia, Bertrand, Jeanluc, Brito, Iván, Salas, Cristian O.

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New 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia by Bertrand, Jeanluc, Dostálová, Hana, Krystof, Vladimir, Jorda, Radek, Castro, Alejandro, Mella, Jaime, Espinosa-Bustos, Christian, María Zarate, Ana, Salas, Cristian O.

“…[Display omitted] •Design and synthesis of new 2,6,9-trisubstituted purine derivatives.•Compounds 5c and 5d were potent inhibitors of both kinases, with IC50…”
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New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer by Espinosa-Bustos, Christian, Bertrand, Jeanluc, Villegas-Menares, Alondra, Guerrero, Simón, Di Marcotullio, Lucia, Navacci, Shirin, Schulte, Gunnar, Kozielewicz, Pawel, Bloch, Nicolas, Villela, Valentina, Paulino, Margot, Kogan, Marcelo J., Cantero, Jorge, Salas, Cristian O.

“…[Display omitted] •Design and synthesis of new 2,6,9-trisubstituted purine derivatives.•8f, 8g and 8h have IC50 values of 4.56, 4.11 and 3.08 μM on Mia-PaCa-2…”
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