Search Results - "Bertrand, Jean‐Remi"

Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells by Alhaddad, Anna, Adam, Marie-Pierre, Botsoa, Jacques, Dantelle, Géraldine, Perruchas, Sandrine, Gacoin, Thierry, Mansuy, Christelle, Lavielle, Solange, Malvy, Claude, Treussart, François, Bertrand, Jean-Rémi

“…The ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) into Ewing sarcoma cells is investigated with a view to the…”
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Fluorescent Nanodiamond Applications for Cellular Process Sensing and Cell Tracking by Claveau, Sandra, Bertrand, Jean-Rémi, Treussart, François

“…Diamond nanocrystals smaller than 100 nm (nanodiamonds) are now recognized to be highly biocompatible. They can be made fluorescent with perfect photostability…”
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Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers by Gauthier, Florian, Bertrand, Jean-Rémi, Vasseur, Jean-Jacques, Dupouy, Christelle, Debart, Françoise

“…Co-delivery systems of siRNA and chemotherapeutic drugs have been developed as an attractive strategy to optimize the efficacy of chemotherapy towards cancer…”
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Gymnotic delivery and gene silencing activity of reduction-responsive siRNAs bearing lipophilic disulfide-containing modifications at 2′-position by Gauthier, Florian, Claveau, Sandra, Bertrand, Jean-Rémi, Vasseur, Jean-Jacques, Dupouy, Christelle, Debart, Françoise

“…[Display omitted] Modified oligoribonucleotides used as siRNAs bearing biolabile disulfide-containing groups at some 2′-positions were synthesized following a…”
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Cellular uptake pathways of sepiolite nanofibers and DNA transfection improvement by Castro-Smirnov, Fidel Antonio, Ayache, Jeanne, Bertrand, Jean-Rémi, Dardillac, Elodie, Le Cam, Eric, Piétrement, Olivier, Aranda, Pilar, Ruiz-Hitzky, Eduardo, Lopez, Bernard S.

“…Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier because it can be naturally internalized into mammalian cells, due to its…”
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Physical interactions between DNA and sepiolite nanofibers, and potential application for DNA transfer into mammalian cells by Castro-Smirnov, Fidel Antonio, Piétrement, Olivier, Aranda, Pilar, Bertrand, Jean-Rémi, Ayache, Jeanne, Le Cam, Eric, Ruiz-Hitzky, Eduardo, Lopez, Bernard S.

“…Nanofibers of sepiolite, a natural silicate belonging to the clay minerals family, might constitute a potential promising nanocarrier for the non-viral…”
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Influence of the internalization pathway on the efficacy of siRNA delivery by cationic fluorescent nanodiamonds in the Ewing sarcoma cell model by Alhaddad, Anna, Durieu, Catherine, Dantelle, Géraldine, Le Cam, Eric, Malvy, Claude, Treussart, François, Bertrand, Jean-Rémi

“…Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to…”
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Plasma hydrogenated cationic detonation nanodiamonds efficiently deliver to human cells in culture functional siRNA targeting the Ewing sarcoma junction oncogene by Bertrand, Jean-Rémi, Pioche-Durieu, Catherine, Ayala, Juan, Petit, Tristan, Girard, Hugues A, Malvy, Claude P, Le Cam, Eric, Treussart, François, Arnault, Jean-Charles

“…Abstract The expression of a defective gene can lead to major cell dysfunctions among which cell proliferation and tumor formation. One promising therapeutic…”
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A Base-Labile Group for 2′-OH Protection of Ribonucleosides: A Major Challenge for RNA Synthesis by Lavergne, Thomas, Bertrand, Jean-Rémi, Vasseur, Jean-Jacques, Debart, Françoise

“…A novel methodology that disrupts the dogma “RNA synthesis is incompatible with a whole base‐labile strategy” has been developed. In this strategy (see…”
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Lipophilic 2′-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery by Biscans, Annabelle, Bertrand, Jean-Rémi, Dubois, Josephine, Rüger, Jacqueline, Vasseur, Jean-Jacques, Sczakiel, Georg, Dupouy, Christelle, Debart, Françoise

“…The in vivo application of siRNA depends on its cellular uptake and intracellular release, and this is an unsatisfactorily resolved technical hurdle in…”
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Delivery of siRNA to Ewing Sarcoma Tumor Xenografted on Mice, Using Hydrogenated Detonation Nanodiamonds: Treatment Efficacy and Tissue Distribution by Claveau, Sandra, Nehlig, Émilie, Garcia-Argote, Sébastien, Feuillastre, Sophie, Pieters, Grégory, Girard, Hugues A, Arnault, Jean-Charles, Treussart, François, Bertrand, Jean-Rémi

“…Nanodiamonds of detonation origin are promising delivery agents of anti-cancer therapeutic compounds in a whole organism like mouse, owing to their versatile…”
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Synthesis, binding, nuclease resistance and cellular uptake properties of 2′-O-acetalester-modified oligonucleotides containing cationic groups by Biscans, Annabelle, Rouanet, Sonia, Bertrand, Jean-Rémi, Vasseur, Jean-Jacques, Dupouy, Christelle, Debart, Françoise

“…[Display omitted] We report on the synthesis and properties of oligonucleotides (ONs) with 2′-O-acetalester modifications containing cationic side chains in a…”
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Effects of siRNA on RET/PTC3 junction oncogene in papillary thyroid carcinoma: from molecular and cellular studies to preclinical investigations by Ali, Hafiz Muhammad, Urbinati, Giorgia, Chapuis, Hubert, Desmaele, Didier, Bertrand, Jean-Rémi, Couvreur, Patrick, Massaad-Massade, Liliane

“…RET/PTC3 junction oncogene is typical of radiation-induced childhood papillary thyroid carcinoma (PTC) with a short latency period. Since, RET/PTC3 is only…”
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siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma by de Martimprey, Henri, Bertrand, Jean-Remi, Fusco, Alfredo, Santoro, Massimo, Couvreur, Patrick, Vauthier, Christine, Malvy, Claude

“…Delivery is a very important concern for therapeutic applications of siRNA. In this study, we have used chitosan-coated poly(isobutylcyanoacrylate)…”
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Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in ewing sarcoma by TOUB, Nedjma, BERTRAND, Jean-Rémi, TAMADDON, Ali, ELHAMESS, Hind, HILLAIREAU, Hervé, MAKSIMENKO, Andrei, MACCARIO, Jean, MALVY, Claude, FATTAL, Elias, COUVREUR, Patrick

“…The EWS-Fli1 fusion gene encodes for a chimeric oncogenic transcription factor considered to be the cause of the Ewing sarcoma. The efficiency of small…”
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New Core-Shell Nanoparticules for the Intravenous Delivery of siRNA to Experimental Thyroid Papillary Carcinoma by de Martimprey, Henri, Bertrand, Jean-Rémi, Malvy, Claude, Couvreur, Patrick, Vauthier, Christine

“…Purpose Development of efficient in vivo delivery nanodevices remains a major challenge to achieve clinical application of siRNA. The present study refers to…”
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Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells by Bertrand, Jean-Rémi, Lucas, Claire, Pham, Ngoc Minh, Durieu, Catherine, Couvreur, Patrick, Malvy, Claude Paul, Desmaële, Didier

“…Covalent binding of squalene to siRNA has already been shown to be an interesting way of delivering siRNA in vivo. Whether squalene derivatives could also be…”
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Optimisation of dendrimer-mediated gene transfer by anionic oligomers by Maksimenko, Andrei V., Mandrouguine, Vasilii, Gottikh, Marina B., Bertrand, Jean-Remi, Majoral, Jean-Pierre, Malvy, Claude

“…Background The application of synthetic vectors for gene transfer has potential advantages over virus‐based systems. Their use, however, is limited since they…”
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Microscopic observation of living cells during their exposure to modulated electromagnetic fields by Moisescu, Mihaela G., Leveque, Philippe, Bertrand, Jean-Rémi, Kovacs, Eugenia, Mir, Lluis M.

“…Studying cell behaviour under irradiation with radiofrequency electromagnetic fields (RF-EMF) is often impeded by the difficulty to monitor cell…”
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In Vivo Potentialities of EWS-Fli-1 Targeted Antisense Oligonucleotides-Nanospheres Complexes by MAKSIMENKO, ANDREI, POLARD, VALERIE, VILLEMEUR, MARIE, ELHAMESS, HIND, COUVREUR, PATRICK, BERTRAND, JEAN-REMI, ABOUBAKAR, MALAM, GOTTIKH, MARINA, MALVY, CLAUDE

“…The EWS/FLI‐1 fusion gene, resulting from a t(11;22) translocation, plays a key role in the pathogenesis of Ewing sarcoma. Previously, we have shown that…”
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