Search Results - "Bertrand, Fred E"

The Notch pathway in colorectal cancer by Vinson, Kaitlyn E., George, Dennis C., Fender, Alexander W., Bertrand, Fred E., Sigounas, George

“…Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. It is also the third most common cancer diagnosis among men, and the second most…”
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Notch-1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer by Fender, Alexander W., Nutter, Jennifer M., Fitzgerald, Timothy L., Bertrand, Fred E., Sigounas, George

“…ABSTRACT Colorectal cancer (CRC) is the third leading cause of cancer death in the United States, resulting in an average of 50,000 deaths per year. Surgery…”
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The cross-talk of NOTCH and GSK-3 signaling in colon and other cancers by Bertrand, Fred E.

“…The GSK-3 kinases, GSK-3α and GSK-3β, have a central role in regulating multiple cellular processes such as glycogen synthesis, insulin signaling, cell…”
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CBF-1 (RBP-Jk) Binds to the PTEN Promoter and Regulates PTEN Gene Expression by Whelan, Jarrett T, Forbes, Siiri L, Bertrand, Fred E

“…The PTEN gene regulates multiple signaling pathways that influence cell proliferation, survival and differentiation. Loss of PTEN expression is closely linked…”
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Developmental pathways in colon cancer: Crosstalk between WNT, BMP, Hedgehog and Notch by Bertrand, Fred E., Angus, C. William, Partis, William J., Sigounas, George

“…A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT,…”
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The complexity of PTEN: mutation, marker and potential target for therapeutic intervention by Steelman, Linda S, Bertrand, Fred E, McCubrey, James A

“…Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatase that removes phosphates primarily from lipids. It has also been called…”
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A potential requirement for Smad3 phosphorylation in Notch-mediated EMT in colon cancer by Clark, Alexander G., Bertrand, Fred E., Sigounas, George

“…Colorectal cancer (CRC) remains a challenging disease to treat due to several factors including stemness and epithelial to mesenchymal transition (EMT)…”
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Notch-3 affects chemoresistance in colorectal cancer via DNA base excision repair enzymes by George, Dennis C., Bertrand, Fred E., Sigounas, George

“…Colon cancer is the second leading cause of cancer death. With over 153,000 new CRC cases predicted, it is the third most commonly diagnosed cancer. Early…”
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GSK-3 as potential target for therapeutic intervention in cancer by McCubrey, James A, Steelman, Linda S, Bertrand, Fred E, Davis, Nicole M, Sokolosky, Melissa, Abrams, Steve L, Montalto, Giuseppe, D'Assoro, Antonino B, Libra, Massimo, Nicoletti, Ferdinando, Maestro, Roberta, Basecke, Jorg, Rakus, Dariusz, Gizak, Agnieszka, Demidenko, Zoya N, Cocco, Lucio, Martelli, Alberto M, Cervello, Melchiorre

“…The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. GSK-3 functions in…”
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Increased Protein Expression of the PTEN Tumor Suppressor in the Presence of Constitutively Active Notch-1 by Chappell, William H., Green, Thomas D., Spengeman, Justin D., McCubrey, James A, Akula, Shaw M., Bertrand, Fred E.

“…Mammalian Notch-1 is part of an evolutionarily conserved family of transmembrane receptorsbest known for involvement in cell fate decisions. Mutations that…”
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The MLL partial tandem duplication in acute myeloid leukaemia by Basecke, Jorg, Whelan, Jarrett T., Griesinger, Frank, Bertrand, Fred E.

“…Summary Mixed lineage leukaemia gene‐partial tandem duplications (MLL‐PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal…”
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NOTCH and PTEN in prostate cancer by Bertrand, Fred E., McCubrey, James A., Angus, C. William, Nutter, Jennifer M., Sigounas, George

“…Over the past decade, our understanding of the role that Notch-signaling has in tumorigenesis has shifted from leukemogenesis into cancers of solid tumors…”
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Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines by Shelton, John G., Steelman, Linda S., Abrams, Steven L., White, Edmund R., Akula, Shaw M., Franklin, Richard A., Bertrand, Fred E., McMahon, Martin, McCubrey, James A

“…v-ErbB is an oncogene related to the Epidermal Growth Factor Receptor (EGFR). EGFR overexpression has been observed in many pathological situations. There is a…”
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Acquired immunodeficiency syndrome associated lymphoma by Bertrand, Fred E, McCubrey, James A

“…A prior diagnosis of HIV increases the risk of lymphoma between 150 to 250- fold, depending on the subtype, as compared with the risk observed in the general…”
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Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression by Whelan, Jarrett T., Kellogg, Anne, Shewchuk, Brian M., Hewan-Lowe, Karlene, Bertrand, Fred E.

“…Prostate tumorigenesis is associated with loss of PTEN gene expression. We and others have recently reported that PTEN is regulated by Notch‐1 signaling…”
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Upping the bid on engineered inducible cell death by McCubrey, James A., Bertrand, Fred E.

“…Commentary to: An Optimized Conditional Suicide Switch Using Doxycycline-Dependent Expression of Human tBid Anja Knott, Lars Drueppel, Thomas Beyer, Kristin…”
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Activated EGFR Promotes the Survival of B-Lineage Acute Leukemia in the Absence of Stromal Cells by Spengeman, Justin D., Green, Thomas D., McCubrey, James A, Bertrand, Fred E.

“…B-lineage acute leukemia (B-ALL) cells often require stromal cell support for optimal proliferation and apoptotic resistance. In addition, stromal cell contact…”
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Effects of Endogenous Epidermal Growth Factor Receptor Signaling on DNA Synthesis and ERK Activation in a Cytokine-Dependent Hematopoietic Cell Line by Shelton, John G., Steelman, Linda S., Abrams, Steven L., White, Edmund R., Akula, Shaw M., Bertrand, Fred E., Franklin, Richard A., McCubrey, James A

“…Epidermal growth factor (EGF) is commonly thought to affect the proliferation of many cells, especially epithelial cells. Aberrant expression of the receptor…”
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Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance by McCubrey, James A., Steelman, Linda S., Abrams, Steven L., Lee, John T., Chang, Fumin, Bertrand, Fred E., Navolanic, Patrick M., Terrian, David M., Franklin, Richard A., D’Assoro, Antonio B., Salisbury, Jeffrey L., Mazzarino, Maria Clorinda, Stivala, Franca, Libra, Massimo

“…The Ras/Raf/MEK/ERK and PI3K/PTEN/AKT signaling cascades play critical roles in the transmission of signals from growth factor receptors to regulate gene…”
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Label-free classification of cultured cells through diffraction imaging by Dong, Ke, Feng, Yuanming, Jacobs, Kenneth M, Lu, Jun Q, Brock, R Scott, Yang, Li V, Bertrand, Fred E, Farwell, Mary A, Hu, Xin-Hua

“…Automated classification of biological cells according to their 3D morphology is highly desired in a flow cytometer setting. We have investigated this…”
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