Search Results - "Bertrand, Daniel"

Nicotinic acetylcholine receptors: From basic science to therapeutics by HURST, Raymond, ROLLEMA, Hans, BERTRAND, Daniel

“…Substantial progress in the identification of genes encoding for a large number of proteins responsible for various aspects of neurotransmitter release,…”
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Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system by DANI, John A, BERTRAND, Daniel

“…Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with…”
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Allosteric modulation of nicotinic acetylcholine receptors by Bertrand, Daniel, Gopalakrishnan, Murali

“…Allosteric modulation refers to the concept that proteins could exist in multiple conformational states and that binding of allosteric ligands alters the…”
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Tuning the Reactivity of a Heterogeneous Catalyst using N‐Heterocyclic Carbene Ligands for C−H Activation Reactions by Palazzolo, Alberto, Naret, Timothée, Daniel‐Bertrand, Marion, Buisson, David‐Alexandre, Tricard, Simon, Lesot, Philippe, Coppel, Yannick, Chaudret, Bruno, Feuillastre, Sophie, Pieters, Grégory

“…We report the dramatic impact of the addition of N‐heterocyclic carbenes (NHCs) on the reactivity and selectivity of heterogeneous Ru catalysts in the context…”
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Nicotinic acetylcholine receptors in neurological and psychiatric diseases by Terry, Alvin V., Jones, Keri, Bertrand, Daniel

“…Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are widely distributed both pre- and post-synaptically in the mammalian…”
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Multiple Site Hydrogen Isotope Labelling of Pharmaceuticals by Daniel‐Bertrand, Marion, Garcia‐Argote, Sébastien, Palazzolo, Alberto, Mustieles Marin, Irene, Fazzini, Pier‐Francesco, Tricard, Simon, Chaudret, Bruno, Derdau, Volker, Feuillastre, Sophie, Pieters, Grégory

“…Radiolabelling is fundamental in drug discovery and development as it is mandatory for preclinical ADME studies and late‐stage human clinical trials. Herein, a…”
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Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors by Bertrand, Daniel, Lee, Chih-Hung L, Flood, Dorothy, Marger, Fabrice, Donnelly-Roberts, Diana

“…Progress in the fields of neuroscience and molecular biology has identified the forebrain cholinergic system as being important in many higher order brain…”
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The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls) by Rufener, Lucien, Danelli, Vanessa, Bertrand, Daniel, Sager, Heinz

“…The isoxazolines are a novel class of parasiticides that are potent inhibitors of γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and, to a lesser…”
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The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors by Nys, Mieke, Zarkadas, Eleftherios, Brams, Marijke, Mehregan, Aujan, Kambara, Kumiko, Kool, Jeroen, Casewell, Nicholas R., Bertrand, Daniel, Baenziger, John E., Nury, Hugues, Ulens, Chris

“…Bites by elapid snakes (e.g. cobras) can result in life-threatening paralysis caused by venom neurotoxins blocking neuromuscular nicotinic acetylcholine…”
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The SARS-CoV-2 Virus and the Cholinergic System: Spike Protein Interaction with Human Nicotinic Acetylcholine Receptors and the Nicotinic Agonist Varenicline by Carlson, Eric C, Macsai, Marian, Bertrand, Sonia, Bertrand, Daniel, Nau, Jeffrey

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the worldwide coronavirus disease 2019 (COVID-19) pandemic. Although the…”
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Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function by Buisson, Bruno, Bertrand, Daniel

“…Widely expressed in the brain, the α4β2 nicotinic acetylcholine receptor (nAChR) is proposed to play a major role in the mechanisms that lead to and maintain…”
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Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor by Spurny, Radovan, Debaveye, Sarah, Farinha, Ana, Veys, Ken, Vos, Ann M., Gossas, Thomas, Atack, John, Bertrand, Sonia, Bertrand, Daniel, Danielson, U. Helena, Tresadern, Gary, Ulens, Chris

“…The α7 nicotinic acetylcholine receptor (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in fast synaptic signaling. In…”
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Molecular Characterization of Off-Target Activities of Telithromycin: a Potential Role for Nicotinic Acetylcholine Receptors by BERTRAND, Daniel, BERTRAND, Sonia, NEVEU, Estelle, FERNANDES, Prabhavathi

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Author Correction: The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors by Nys, Mieke, Zarkadas, Eleftherios, Brams, Marijke, Mehregan, Aujan, Kambara, Kumiko, Kool, Jeroen, Casewell, Nicholas R., Bertrand, Daniel, Baenziger, John E., Nury, Hugues, Ulens, Chris

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Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides by Chen, Shiyu, Gopalakrishnan, Ranganath, Schaer, Tifany, Marger, Fabrice, Hovius, Ruud, Bertrand, Daniel, Pojer, Florence, Heinis, Christian

“…The disulfide bonds that form between two cysteine residues are important in defining and rigidifying the structures of proteins and peptides. In polypeptides…”
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The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7nAChR function by Araud, Tanguy, Graw, Sharon, Berger, Ralph, Lee, Michael, Neveu, Estele, Bertrand, Daniel, Leonard, Sherry

“…The human α7 neuronal nicotinic acetylcholine receptor gene ( CHRNA7) is a candidate gene for schizophrenia and an important drug target for cognitive deficits…”
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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines by Spurny, Radovan, Ramerstorfer, Joachim, Price, Kerry, Brams, Marijke, Ernst, Margot, Nury, Hugues, Verheij, Mark, Legrand, Pierre, Bertrand, Daniel, Bertrand, Sonia, Dougherty, Dennis A, de Esch, Iwan J. P, Corringer, Pierre-Jean, Sieghart, Werner, Lummis, Sarah C. R, Ulens, Chris

“…GABA A receptors are pentameric ligand-gated ion channels involved in fast inhibitory neurotransmission and are allosterically modulated by the anxiolytic,…”
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Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors by Foo, Chun Shin, Jobichen, Chacko, Hassan‐Puttaswamy, Varuna, Dekan, Zoltan, Tae, Han‐Shen, Bertrand, Daniel, Adams, David J., Alewood, Paul F., Sivaraman, J., Nirthanan, Selvanayagam, Kini, R. Manjunatha

“…Background and Purpose Animal toxins have contributed significantly to our understanding of the neurobiology of receptors and ion channels. We studied the…”
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The ‘Ornithologists’, the ‘Birds’, and the Meaning of the ‘Meaning of Europe’: Keynote Address to the EAHN on the Occasion of its Tenth Anniversary by Monk, Daniel Bertrand

“…This essay questions the unspoken assumptions behind the issues raised about the 'meaning of "Europe"' by the organizers of the EAHN roundtable session in 2017…”
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Nicotinic receptor channelopathies and epilepsy by Steinlein, Ortrud K., Bertrand, Daniel

“…Characterized by sudden episodes called seizures, epilepsy was recognized long ago as a neurological disorder that can have multiple forms ranging from benign…”
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