Search Results - "Bertram, Lars"

The Genetics of Alzheimer Disease: Back to the Future by Bertram, Lars, Lill, Christina M., Tanzi, Rudolph E.

“…Three decades of genetic research in Alzheimer disease (AD) have substantially broadened our understanding of the pathogenetic mechanisms leading to…”
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Genotype‐Phenotype Relations for the Parkinson's Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review by Kasten, Meike, Hartmann, Corinna, Hampf, Jennie, Schaake, Susen, Westenberger, Ana, Vollstedt, Eva‐Juliane, Balck, Alexander, Domingo, Aloysius, Vulinovic, Franca, Dulovic, Marija, Zorn, Ingo, Madoev, Harutyun, Zehnle, Hanna, Lembeck, Christina M., Schawe, Leopold, Reginold, Jennifer, Huang, Jana, König, Inke R., Bertram, Lars, Marras, Connie, Lohmann, Katja, Lill, Christina M., Klein, Christine

“…This first comprehensive MDSGene review is devoted to the 3 autosomal recessive Parkinson's disease forms: PARK‐Parkin, PARK‐PINK1, and PARK‐DJ1. It followed…”
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Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective by Tanzi, Rudolph E., Bertram, Lars

“…From Alois Alzheimer’s description of Auguste D.’s brain in 1907 to George Glenner’s biochemical dissection of β-amyloid in 1984, the “amyloid hypothesis” of…”
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Nomenclature of genetic movement disorders: Recommendations of the international Parkinson and movement disorder society task force by Marras, Connie, Lang, Anthony, van de Warrenburg, Bart P., Sue, Carolyn M., Tabrizi, Sarah J., Bertram, Lars, Mercimek-Mahmutoglu, Saadet, Ebrahimi-Fakhari, Darius, Warner, Thomas T., Durr, Alexandra, Assmann, Birgit, Lohmann, Katja, Kostic, Vladimir, Klein, Christine

“…ABSTRACT The system of assigning locus symbols to specify chromosomal regions that are associated with a familial disorder has a number of problems when used…”
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The future of Alzheimer's disease: the next 10 years by Hampel, Harald, Prvulovic, David, Teipel, Stefan, Jessen, Frank, Luckhaus, Christian, Frölich, Lutz, Riepe, Matthias W, Dodel, Richard, Leyhe, Thomas, Bertram, Lars, Hoffmann, Wolfgang, Faltraco, Frank

“…Alzheimer's disease (AD) is a fast growing world-wide epidemic. AD is a genetically complex, slowly progressive, and irreversible neurodegenerative disease of…”
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Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change by Vidal-Pineiro, Didac, Wang, Yunpeng, Krogsrud, Stine K, Amlien, Inge K, Baaré, William F C, Bartres-Faz, David, Bertram, Lars, Brandmaier, Andreas M, Drevon, Christian A, Düzel, Sandra, Ebmeier, Klaus, Henson, Richard N, Junqué, Carme, Kievit, Rogier Andrew, Kühn, Simone, Leonardsen, Esten, Lindenberger, Ulman, Madsen, Kathrine S, Magnussen, Fredrik, Mowinckel, Athanasia Monika, Nyberg, Lars, Roe, James M, Segura, Barbara, Smith, Stephen M, Sørensen, Øystein, Suri, Sana, Westerhausen, Rene, Zalesky, Andrew, Zsoldos, Enikő, Walhovd, Kristine Beate, Fjell, Anders

“…is a widely used index for quantifying individuals' brain health as deviation from a normative brain aging trajectory. Higher-than-expected is thought…”
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Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics by Wohlers, Inken, Bertram, Lars, Lill, Christina M.

“…Genome-wide association studies (GWAS) have identified a large number of genetic risk loci for autoimmune diseases. However, the functional variants underlying…”
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Clinico-genetic findings in 509 frontotemporal dementia patients by Wagner, Matias, Lorenz, Georg, Volk, Alexander E., Brunet, Theresa, Edbauer, Dieter, Berutti, Riccardo, Zhao, Chen, Anderl-Straub, Sarah, Bertram, Lars, Danek, Adrian, Deschauer, Marcus, Dill, Veronika, Fassbender, Klaus, Fliessbach, Klaus, Götze, Katharina S., Jahn, Holger, Kornhuber, Johannes, Landwehrmeyer, Bernhard, Lauer, Martin, Obrig, Hellmuth, Prudlo, Johannes, Schneider, Anja, Schroeter, Matthias L., Uttner, Ingo, Vukovich, Ruth, Wiltfang, Jens, Winkler, Andrea S., Zhou, Qihui, Ludolph, Albert C., Oexle, Konrad, Otto, Markus, Diehl-Schmid, Janine, Winkelmann, Juliane

“…Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains…”
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Seven-CpG DNA Methylation Age Determined by Single Nucleotide Primer Extension and Illumina's Infinium MethylationEPIC Array Provide Highly Comparable Results by Vetter, Valentin Max, Kalies, Christian Humberto, Sommerer, Yasmine, Bertram, Lars, Demuth, Ilja

“…DNA methylation age (DNAm age, epigenetic clock) is a novel and promising biomarker of aging. It is calculated from the methylation fraction of specific…”
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Epigenetic aging and perceived psychological stress in old age by Vetter, Valentin Max, Drewelies, Johanna, Sommerer, Yasmine, Kalies, Christian Humberto, Regitz-Zagrosek, Vera, Bertram, Lars, Gerstorf, Denis, Demuth, Ilja

“…Adverse effects of psychological stress on physical and mental health, especially in older age, are well documented. How perceived stress relates to the…”
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New Frontiers in Alzheimer's Disease Genetics by Tanzi, Rudolph E., Bertram, Lars

“…Alzheimer's disease (AD) is a genetically complex disorder that accounts for the majority of dementia in the elderly population. Over 100 rare, highly…”
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Differential microRNA expression analyses across two brain regions in Alzheimer’s disease by Dobricic, Valerija, Schilling, Marcel, Schulz, Jessica, Zhu, Ling-Shuang, Zhou, Chao-Wen, Fuß, Janina, Franzenburg, Sören, Zhu, Ling-Qiang, Parkkinen, Laura, Lill, Christina M., Bertram, Lars

“…Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). Hitherto, sample sizes…”
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Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis by Timmermann, Bernd, Kerick, Martin, Roehr, Christina, Fischer, Axel, Isau, Melanie, Boerno, Stefan T, Wunderlich, Andrea, Barmeyer, Christian, Seemann, Petra, Koenig, Jana, Lappe, Michael, Kuss, Andreas W, Garshasbi, Masoud, Bertram, Lars, Trappe, Kathrin, Werber, Martin, Herrmann, Bernhard G, Zatloukal, Kurt, Lehrach, Hans, Schweiger, Michal R

“…Colorectal cancer (CRC) is with approximately 1 million cases the third most common cancer worldwide. Extensive research is ongoing to decipher the underlying…”
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Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE by Bertram, Lars, Lange, Christoph, Mullin, Kristina, Parkinson, Michele, Hsiao, Monica, Hogan, Meghan F., Schjeide, Brit M.M., Hooli, Basavaraj, DiVito, Jason, Ionita, Iuliana, Jiang, Hongyu, Laird, Nan, Moscarillo, Thomas, Ohlsen, Kari L., Elliott, Kathryn, Wang, Xin, Hu-Lince, Diane, Ryder, Marie, Murphy, Amy, Wagner, Steven L., Blacker, Deborah, Becker, K. David, Tanzi, Rudolph E.

“…Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four genes have been established to either cause early-onset…”
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Change in body weight of older adults before and during the COVID-19 pandemic: longitudinal results from the Berlin Aging Study II by Vetter, Valentin Max, Drewelies, Johanna, Düzel, Sandra, Homann, Jan, Meyer-Arndt, Lil, Braun, Julian, Pohrt, Anne, Kendel, Friederike, Wagner, Gert G., Thiel, Andreas, Bertram, Lars, Regitz-Zagrosek, Vera, Gerstorf, Denis, Demuth, Ilja

“…Change in body weight during the COVID-19 pandemic as an unintended side effect of lockdown measures has been predominantly reported for younger and…”
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Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study by Pichler, Irene, Del Greco M, Fabiola, Gögele, Martin, Lill, Christina M, Bertram, Lars, Do, Chuong B, Eriksson, Nicholas, Foroud, Tatiana, Myers, Richard H, Nalls, Michael, Keller, Margaux F, Benyamin, Beben, Whitfield, John B, Pramstaller, Peter P, Hicks, Andrew A, Thompson, John R, Minelli, Cosetta

“…Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron…”
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A common polymorphism in the dopamine transporter gene predicts working memory performance and in vivo dopamine integrity in aging by Karalija, Nina, Köhncke, Ylva, Düzel, Sandra, Bertram, Lars, Papenberg, Goran, Demuth, Ilja, Lill, Christina M., Johansson, Jarkko, Riklund, Katrine, Lövdén, Martin, Bäckman, Lars, Nyberg, Lars, Lindenberger, Ulman, Brandmaier, Andreas M.

“…Dopamine (DA) integrity is suggested as a potential cause of individual differences in working memory (WM) performance among older adults. Still, the principal…”
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Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease by Morgan, Sarah L., Naderi, Pourya, Koler, Katjuša, Pita-Juarez, Yered, Prokopenko, Dmitry, Vlachos, Ioannis S., Tanzi, Rudolph E., Bertram, Lars, Hide, Winston A.

“…Alzheimer’s disease (AD) is a complex neurodegenerative disorder. The relative contribution of the numerous underlying functional mechanisms is poorly…”
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Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease by Sommerer, Yasmine, Dobricic, Valerija, Schilling, Marcel, Ohlei, Olena, Sabet, Sanaz Sedghpour, Wesse, Tanja, Fuß, Janina, Franzenburg, Sören, Franke, Andre, Parkkinen, Laura, Lill, Christina M, Bertram, Lars

“…Studies on DNA methylation (DNAm) in Alzheimer's disease (AD) have recently highlighted several genomic loci showing association with disease onset and…”
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The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics by Bos, Isabelle, Vos, Stephanie, Vandenberghe, Rik, Scheltens, Philip, Engelborghs, Sebastiaan, Frisoni, Giovanni, Molinuevo, José Luis, Wallin, Anders, Lleó, Alberto, Popp, Julius, Martinez-Lage, Pablo, Baird, Alison, Dobson, Richard, Legido-Quigley, Cristina, Sleegers, Kristel, Van Broeckhoven, Christine, Bertram, Lars, Ten Kate, Mara, Barkhof, Frederik, Zetterberg, Henrik, Lovestone, Simon, Streffer, Johannes, Visser, Pieter Jelle

“…There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer's disease (AD) in the predementia stages and to predict the rate of decline…”
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