Search Results - "Bertram, Arrien A"
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EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd
Published in Cancer research (Chicago, Ill.) (01-01-2022)“…Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are the standard-of-care treatment for -mutant non-small cell lung cancers (NSCLC)…”
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Low peripheral blood derived neutrophil-to-lymphocyte ratio (dNLR) is associated with increased tumor T-cell infiltration and favorable outcomes to first-line pembrolizumab in non-small cell lung cancer
Published in Journal for immunotherapy of cancer (01-11-2021)“…BackgroundAn elevated peripheral blood derived neutrophil-to-lymphocyte ratio (dNLR) is a negative prognostic marker for patients with non-small cell lung…”
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3
Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors
Published in Nature communications (24-09-2022)“…The clinical significance of gene fusions detected by DNA-based next generation sequencing remains unclear as resistance mechanisms to EGFR tyrosine kinase…”
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4
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
Published in Cancer cell (13-01-2020)“…Eradicating tumor dormancy that develops following epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small…”
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Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion-Positive Lung Cancer by Combining Selpercatinib with Crizotinib
Published in Clinical cancer research (01-01-2021)“…The proto-oncogene encodes a receptor tyrosine kinase that is activated by gene fusion in 1%-2% of non-small cell lung cancers (NSCLC) and rarely in other…”
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Germline EGFR Mutations and Familial Lung Cancer
Published in Journal of clinical oncology (01-12-2023)“…The genomic underpinnings of inherited lung cancer risk are poorly understood. This prospective study characterized the clinical phenotype of patients and…”
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Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non-Small Cell Lung Cancer
Published in Clinical cancer research (05-07-2023)“…ATM is the most commonly mutated DNA damage and repair gene in non-small cell lung cancer (NSCLC); however, limited characterization has been pursued…”
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ERK Inhibitor LY3214996-Based Treatment Strategies for RAS -Driven Lung Cancer
Published in Molecular cancer therapeutics (01-04-2021)“…gene mutations are the most frequent oncogenic event in lung cancer. They activate multiple RAS-centric signaling networks among them the MAPK, PI3K, and RB…”
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Activation of Tumor-Cell STING Primes NK-Cell Therapy
Published in Cancer immunology research (03-08-2022)“…Activation of the stimulator of interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased…”
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Plasma cfDNA Genotyping in Hospitalized Patients With Suspected Metastatic NSCLC
Published in JCO precision oncology (01-11-2021)“…Next-generation sequencing (NGS) is an important component of first-line treatment selection for metastatic non-small-cell lung cancer (NSCLC) and is typically…”
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Abstract 2143: Clinicopathologic, genomic and immunophenotypic landscape of ATM mutations in non-small cell lung cancer
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Introduction: Defective DNA damage repair machinery is a hallmark of cancer, resulting in increased mutation rates and genomic instability. In…”
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Abstract C070: REAL variance in genomic testing by sex, age, race, ethnicity, and language: PROFILE database 7/2011 - 1/2022
Published in Cancer epidemiology, biomarkers & prevention (01-01-2023)“…Abstract Background: Lack of representation in genomic databases limits the generalizability of study findings, predictive models, and therapeutics. In cancer,…”
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