Search Results - "Bertoldo, Jean"

RNA-binding proteins in cancer drug discovery by Bertoldo, Jean B., Müller, Simon, Hüttelmaier, Stefan

“…•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion, invasion, migration and metastasis, hence promising drug targets in cancer…”
Get full text

Chemo- and Regioselective Lysine Modification on Native Proteins by Matos, Maria J, Oliveira, Bruno L, Martínez-Sáez, Nuria, Guerreiro, Ana, Cal, Pedro M. S. D, Bertoldo, Jean, Maneiro, María, Perkins, Elizabeth, Howard, Julie, Deery, Michael J, Chalker, Justin M, Corzana, Francisco, Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L

“…Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods,…”
Get full text

S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death by Romagny, Sabrina, Bouaouiche, Sarra, Lucchi, Géraldine, Ducoroy, Patrick, Bertoldo, Jean B, Terenzi, Hernan, Bettaieb, Ali, Plenchette, Stéphanie

“…TNFα is a prominent proinflammatory cytokine and a critical mediator for the development of many types of cancer such as breast, colon, prostate, cervical,…”
Get full text

Protein S-nitrosylation: specificity and identification strategies in plants by Lamotte, Olivier, Bertoldo, Jean B, Besson-Bard, Angélique, Rosnoblet, Claire, Aimé, Sébastien, Hichami, Siham, Terenzi, Hernán, Wendehenne, David

“…The role of nitric oxide (NO) as a major regulator of plant physiological functions has become increasingly evident. To further improve our understanding of…”
Get full text

Protein Modifications: From Chemoselective Probes to Novel Biocatalysts by Tomás Bohn Pessatti, Hernán Terenzi, Jean Borges Bertoldo

“…Chemical reactions can be performed to covalently modify specific residues in proteins. When applied to native enzymes, these chemical modifications can…”
Get full text

Posttranslational Chemical Mutagenesis: To Reveal the Role of Noncatalytic Cysteine Residues in Pathogenic Bacterial Phosphatases by Bertoldo, Jean B, Terenzi, Hernán, Hüttelmaier, Stefan, Bernardes, Gonçalo J. L

“…The field of chemical site-selective modification of proteins has progressed extensively in recent decades to enable protein functionalization for imaging,…”
Get full text

The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer by Müller, Simon, Bley, Nadine, Busch, Bianca, Glaß, Markus, Lederer, Marcell, Misiak, Claudia, Fuchs, Tommy, Wedler, Alice, Haase, Jacob, Bertoldo, Jean Borges, Michl, Patrick, Hüttelmaier, Stefan

“…Abstract The IGF2 mRNA-binding protein 1 (IGF2BP1) is a non-catalytic post-transcriptional enhancer of tumor growth upregulated and associated with adverse…”
Get full text

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells by Cal, Pedro M S D, Sieglitz, Florian, Santos, Fábio M F, Parente Carvalho, Cátia, Guerreiro, Ana, Bertoldo, Jean B, Pischel, Uwe, Gois, Pedro M P, Bernardes, Gonçalo J L

“…Fluorophores are indispensable for imaging biological processes. We report the design and synthesis of azide-tagged boronic acid salicylidenehydrazone (BASHY)…”
Get more information

Oxidation and Tyrosine Nitration Induce Structural Changes and Inhibits Plasmodium falciparum Falcipain-2 Activity In Vitro by Bertoldo, Jean B, Terenzi, Hernán

“…Falcipain-2 (FP2) is an important hemoglobinase from the malaria parasite Plasmodium falciparum and a suitable target for the development of an antimalarial…”
Get more information

Unveiling Druggable Pockets by Site-Specific Protein Modification: Beyond Antibody-Drug Conjugates by Martínez, Dailén G., Hüttelmaier, Stefan, Bertoldo, Jean B.

“…Site-specific modification approaches have been extensively employed in the development of protein-based technologies. In this field, stability and activity…”
Get full text

Editorial: Ubiquitin-Modifying Enzymes as Drug Targets and Biomarkers in Cancer by Bell, Jessica L., Malyukova, Alena, Bertoldo, Jean B., Summers, Matthew K., Sun, Yi

Get full text

Proteomic Analysis of Four Brazilian MON810 Maize Varieties and Their Four Non-Genetically-Modified Isogenic Varieties by Balsamo, Geisi M, Cangahuala-Inocente, Gabriela C, Bertoldo, Jean B, Terenzi, Hernán, Arisi, Ana C. M

“…Profiling techniques have been suggested as a nontargeted approach to detect unintended effects in genetically modified (GM) plants. Seedlings from eight…”
Get full text

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification by Lindstedt, Philip R, Aprile, Francesco A, Matos, Maria J, Perni, Michele, Bertoldo, Jean B, Bernardim, Barbara, Peter, Quentin, Jiménez-Osés, Gonzalo, Knowles, Tuomas P. J, Dobson, Christopher M, Corzana, Francisco, Vendruscolo, Michele, Bernardes, Gonçalo J. L

“…Protein behavior is closely regulated by a plethora of post-translational modifications (PTMs). It is therefore desirable to develop approaches to design…”
Get full text

Cloning, Expression, Purification, and Characterization of a Novel Esterase from Lactobacillus plantarum by Brod, Fábio Cristiano Angonesi, Vernal, Javier, Bertoldo, Jean Borges, Terenzi, Hernán, Arisi, Ana Carolina Maisonnave

“…Lactobacillus plantarum is an important lactic acid bacterium, usually found as natural inhabitant of food, such as fermented vegetables and meat products…”
Get full text

Biochemical and Structural Characterization of Two Site-Directed Mutants of Staphylococcus xylosus Lipase by Kolling, Deise Juliana, Bertoldo, Jean Borges, Brod, Fábio Cristiano Angonesi, Vernal, Javier, Terenzi, Hernán, Arisi, Ana Carolina Maisonnave

“…Staphylococcus xylosus AF208229 lipase was expressed in E. coli containing an histidine-tag (WT-Val). In the present work, in order to check the importance of…”
Get full text

Heterologous Expression and Purification of a Heat-Tolerant Staphylococcus xylosus Lipase by Brod, Fábio Cristiano Angonesi, Pelisser, Márcia Regina, Bertoldo, Jean Borges, Vernal, Javier, Bloch, Carlos Jr, Terenzi, Hernán, Arisi, Ana Carolina Maisonnave

“…Staphylococcus xylosus is a microorganism involved in fermentation of meat products and also a natural producer of extracellular lipases. The aim of the…”
Get full text

DIPG-16. THE BIG AND SMALL OF PROTEIN POST-TRANSLATIONAL MODIFICATIONS: TARGETING SUMOYLATION AND CITRULLINATION IN DIFFUSE MIDLINE GLIOMA by Rayner, Benjamin S, Samadder, Arjayeeta, Holliday, Holly, Chen, Yongjuan, Nguyen, Hieu, Lee, Alvin, Liu, Jie, Hayden, Elisha, Ogunmodede, Oluwaseyi S, Rye, Kerry-Anne, Tsoli, Maria, Bertoldo, Jean B, Ziegler, David S

Get full text

Nitric oxide inhibits the ATPase activity of the chaperone-like AAA+ ATPase CDC48, a target for S-nitrosylation in cryptogein signalling in tobacco cells by Astier, Jéremy, Besson-Bard, Angélique, Lamotte, Olivier, Bertoldo, Jean, Bourque, Stéphane, Terenzi, Hernán, Wendehenne, David

“…NO has important physiological functions in plants, including the adaptative response to pathogen attack. We previously demonstrated that cryptogein, an…”
Get more information

Abstract 3056: Copper chelation modulates YTHDF2 RNA-binding protein localization and global translation, in neuronal cancers by Bell, Jessica L., Abruzzese, Domenico K., Kasiou, Erin, Pham, Vu Vu, Bertoldo, Jean B., Michniewicz, Filip, Vittorio, Orazio

“…Abstract Cancers are dependent on copper for growth, angiogenesis and metastasis and copper chelators are in clinical trials against breast cancer, however the…”
Get full text

Structural stability of Staphylococcus xylosus lipase is modulated by Zn(2+) ions by Bertoldo, Jean Borges, Razzera, Guilherme, Vernal, Javier, Brod, Fábio Cristiano Angonesi, Arisi, Ana Carolina Maisonnave, Terenzi, Hernán

“…Lipases are well-known enzymes extensively used in industrial biotransformation processes. Besides, their structural and catalytic characteristics have…”
Get more information