Search Results - "Bertics, P.J."

Membrane Cholesterol Removal from Human Eosinophils Disrupts Cholesterol Rich Membrane Microdomains Resulting in Down Regulated MAP Kinase Signaling but not JAK/STAT Signaling by Burnham, M.E, Bates, M.E, Bertics, P.J

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Exposure to Agents That Alter the Membrane Cholesterol Content of Human Eosinophils is Associated with the Modulation of MAP Kinase Signaling Pathways Critical for Eosinophil Activation by Burnham, M.E, Bates, M.E, Bertics, P.J

“…[...]in vivo cholesterol levels may influence eosinophilic function/inflammatory/capacity…”
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Variations in Human Rhinovirus (HRV)-induced Cytokine Release from Human Alveolar Macrophages Obtained from Individuals with Different Asthma Severity by Gavala, M.L, Bates, M.E, Evans, M.D, Busse, W.W, Bertics, P.J

“…Interestingly, striking similarities exist between features of severe asthma and the response to respiratory infections in asthma, including intensity of…”
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Stimulation of the Nucleotide Receptor P2RX7 Enhances LPS-Induced Interferon-beta Production in Murine Macrophages by Gavala, M.L, Smith, J.A, Zeng, L, Bertics, P.J

“…Because P2RX7 signaling has been linked to NF-kappaB and AP-1 activation, which are both required for IFN-beta enhanceosome formation, we tested the hypothesis…”
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Following Segmental Antigen Challenge, Airway Eosinophils Exhibit Differential Cytokine Regulation of the STAT and ERK Signaling Networks When Compared to Blood Eosinophils by Koziol-White, C.J, Bates, M.E, Bertics, P.J

“…Airway eosinophils (BALEOS) isolated following segmental antigen challenge (SBP-Ag) exhibit multiple phenotypic changes relative to peripheral blood…”
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Thymic Stromal Lymphopoietin Directly Activates Eosinophil Degranulation by Cook, E.B, Stahl, J.L, Schwantes, E.A, Koziol-White, C.J, Bertics, P.J, Graziano, F.M, Mathur, S.K

“…[...]in allergic inflammation, multiple pathways can serve to activate eosinophils, perhaps in a synergistic manner…”
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Nucleotide Receptor P2RX7 Mediates Robust AP-1 Protein Expression in Monocytic Cells by Gavala, M.L, Bertics, P.J

“…Rationale Activation of the nucleotide receptor P2RX7 serves to modulate monocyte/macrophage-induced inflammatory events, but the molecular mechanisms behind…”
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The Crosstalk Between Interleukin-5 (IL-5) - and Chemoattractant/G Protein-Coupled Receptor (GPCR) -mediated Pathways in Human Peripheral Blood Eosinophils by Zhu, Y, Bates, M.E, Bertics, P.J

“…Rationale Exposure of human peripheral blood eosinophils to IL-5 family cytokines is well-recognized to prime/potentiate eosinophil responsiveness and…”
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Human Airway Eosinophils Exhibit Differential Regulation of ERK and STAT5-Associated Signaling Responses to Interleukin-5 (IL-5) and Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) by Koziol, C.J, Bates, M, Bertics, P.J

“…Conversely, although airway eosinophils also exhibit low basal levels of STAT5 phosphorylation, there is a low to negligible enhancement of this endpoint…”
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Activation of protein kinase C by selective binding of arginine-rich polypeptides by LEVENTHAL, P. S, BERTICS, P. J

“…Protein substrates for protein kinase C (PKC) have phosphorylation domains that are typically rich in the basic amino acids arginine and lysine. However,…”
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Activity and cellular localization of an oncogenic glioblastoma multiforme-associated EGF receptor mutant possessing a duplicated kinase domain by Ozer, B H, Wiepz, G J, Bertics, P J

“…A mutation of the epidermal growth factor receptor (EGFR) that results in a tandem kinase domain duplication (TKD-EGFR) has been described in glioblastoma…”
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Rhinovirus (RV)-Stimulated Release of Interferon γ-Inducible Protein 10 (IP-10) by Human Monocytes and Alveolar Macrophages by Korpi, N.L., Bates, M., Hall, D.J., Bertics, P.J.

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Using Liquid Crystals to Report Membrane Proteins Captured by Affinity Microcontact Printing from Cell Lysates and Membrane Extracts by Jang, Chang-Hyun, Tingey, Matthew L, Korpi, Nichole L, Wiepz, Gregory J, Schiller, Joan H, Bertics, Paul J, Abbott, Nicholas L

“…The chemical heterogeneity of proteins makes development of general and facile surface-based methods for protein analysis a substantial challenge, particularly…”
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Human Bronchoalveolar (BAL) Cells Secrete Increased Amounts of Monocyte Chemoattractant Protein 1 (MCP-1) During an Experimental Rhinovirus (RV) Infection by Bates, M., Korpi, N.L., Hall, D.J., Heuser, R.L., Aga, M., Busse, W.W., Bertics, P.J.

“…Alveolar macrophages are critical cells orchestrating the innate and adaptive immune response in the airway…”
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Altered signal transduction responses to cytokines and chemoattractants in airway eosinophils vs blood eosinophils by Bates, M., Farrington, N.N., Heuser, R.G., Bertics, P.J.

“…[...]we tested the hypothesis that blood and airway eosinophils, acquired from bronchoalveolar lavage fluid following segmental antigen challenge, exhibit an…”
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Activation of ERK1 and ERK2 in human eosinophils is regulated by cholesterol: Relevance to IL-5 signal transduction by Bates, M., Heuser, R., Haglund, H., Bertics, P.J.

“…In eosinophils, the activation of the serine-threonine MAP kinases ERK1 and ERK2 is a critical signal transduction event for numerous ligand-induced biological…”
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Rhinovirus-induced activation of intracellular signaling events in human monocytes and alveolar macrophages by Korpi, N.L., Chapman, E.N., Bates, M.E., Bertics, P.J.

“…Respiratory infections with rhinovirus (RV) are a major cause of asthma exacerbations and may contribute to the overall pathogenesis of asthma. Alveolar…”
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Growth hormone stimulates the tyrosine phosphorylation of 42- and 45-kDa ERK-related proteins by WINSTON, L. A, BERTICS, P. J

“…Growth hormone (GH) influences a number of tissue-specific biological activities in diverse cell types. However, little is known about the biochemical pathway…”
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