Search Results - "Berti, Paul J."

Transition-State Analysis of the DNA Repair Enzyme MutY by McCann, Joe A. B, Berti, Paul J

“…The transition state (TS) structure of MutY-catalyzed DNA hydrolysis was solved using multiple kinetic isotope effect (KIE) measurements. MutY is a base…”
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Correction: A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives by Vito, Alyssa, Alarabi, Hussain, Czorny, Shannon, Beiraghi, Omid, Kent, Jeff, Janzen, Nancy, Genady, Afaf R, Al-Karmi, Salma A, Rathmann, Stephanie, Naperstkow, Zoya, Blacker, Megan, Llano, Lisset, Berti, Paul J, Valliant, John F

“…[This corrects the article DOI: 10.1371/journal.pone.0167425.]…”
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A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives by Vito, Alyssa, Alarabi, Hussain, Czorny, Shannon, Beiraghi, Omid, Kent, Jeff, Janzen, Nancy, Genady, Afaf R, Al-Karmi, Salma A, Rathmann, Stephanie, Naperstkow, Zoya, Blacker, Megan, Llano, Lisset, Berti, Paul J, Valliant, John F

“…A convenient strategy to radiolabel a hydrazinonicotonic acid (HYNIC)-derived tetrazine with 99mTc was developed, and its utility for creating probes to image…”
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Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime by Heimhalt, Maren, Jiang, Shan, Berti, Paul J

“…3-Deoxy-d-arabinoheptulosonate 7-phosphate (DAHP) oxime is a transition state mimic inhibitor of bacterial DAHP synthase, with K i = 1.5 μM and a residence…”
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Linear Free Energy Relationship Analysis of Transition State Mimicry by 3‑Deoxy‑d-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic by Balachandran, Naresh, To, Frederick, Berti, Paul J

“…3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthase catalyzes an aldol-like reaction of phosphoenolpyruvate (PEP) with erythrose 4-phosphate (E4P) to…”
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Campylobacter jejuni KDO8P Synthase, Its Inhibition by KDO8P Oxime, and Control of the Residence Time of Slow-Binding Inhibition by Gama, Simanga R, Balachandran, Naresh, Berti, Paul J

“…3-Deoxy-d-manno-2-octulosonate-8-phosphate (KDO8P) synthase catalyzes the first step of lipopolysaccharide biosynthesis, namely condensation of…”
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Measuring Dynamics in Weakly Structured Regions of Proteins Using Microfluidics-Enabled Subsecond H/D Exchange Mass Spectrometry by Rob, Tamanna, Liuni, Peter, Gill, Preet Kamal, Zhu, Shaolong, Balachandran, Naresh, Berti, Paul J, Wilson, Derek J

“…This work introduces an integrated microfluidic device for measuring rapid H/D exchange (HDX) in proteins. By monitoring backbone amide HDX on the millisecond…”
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Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation by Balachandran, Naresh, Grainger, Ryan A., Rob, Tamanna, Liuni, Peter, Wilson, Derek J., Junop, Murray S., Berti, Paul J.

“…α-Carboxyketose synthases, including 3-deoxy-d-arabinoheptulosonate 7-phosphate synthase (DAHPS), are long-standing targets for inhibition. They are…”
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Toward a Detailed Understanding of Base Excision Repair Enzymes:  Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside Transfer by Berti, Paul J, McCann, Joe A. B

“…Berti and McCann discuss the chemistry performed by base excision (BER) enzymes, enzymes that remove nucleobases from DNA in the first step of the repair of…”
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Potent Inhibition of 3‑Deoxy‑d‑arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic by Balachandran, Naresh, Heimhalt, Maren, Liuni, Peter, To, Frederick, Wilson, Derek J, Junop, Murray S, Berti, Paul J

“…3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) synthase catalyzes the first step in the shikimate pathway. It catalyzes an aldol-like reaction of…”
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NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB by Popović, Vladimir, Morrison, Edward, Rosanally, Adam Z, Balachandran, Naresh, Senson, Alexander W, Szabla, Robert, Junop, Murray S, Berti, Paul J

“…NeuB is a bacterial sialic acid synthase used by neuroinvasive bacteria to synthesize N-acetylneuraminate (NeuNAc), helping them to evade the host immune…”
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Adenine Release Is Fast in MutY-catalyzed Hydrolysis of G:A and 8-Oxo-G:A DNA Mismatches by McCann, Joe A.B., Berti, Paul J.

“…MutY, a DNA repair enzyme, is unusual in that it binds exceedingly tightly to its products after the chemical steps of catalysis. Until now it was not known…”
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Transition State Structure for the Hydrolysis of NAD+ Catalyzed by Diphtheria Toxin by Berti, Paul J, Blanke, Steven R, Schramm, Vern L

“…Diphtheria toxin (DTA) uses NAD+ as an ADP-ribose donor to catalyze the ADP-ribosylation of eukaryotic elongation factor 2. This inhibits protein biosynthesis…”
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An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition by Heimhalt, Maren, Mukherjee, Pallavi, Grainger, Ryan A, Szabla, Robert, Brown, Christopher, Turner, Rebecca, Junop, Murray S, Berti, Paul J

“…3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) synthase catalyzes the first step in the shikimate biosynthetic pathway and is an antimicrobial target. We…”
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Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis by Berti, Paul J, Chindemi, Paul

“…Enolpyruvylshikimate 3-phosphate synthase (EPSP synthase, AroA) catalyzes the sixth step in aromatic amino acid biosynthesis. It forms EPSP from shikimate…”
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67 Ga-labelled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes by Ioppolo, Joseph A, Caldwell, Deanna, Beiraghi, Omid, Llano, Lisset, Blacker, Megan, Valliant, John F, Berti, Paul J

“…Abstract Introduction Deferoxamine (DFO) is a siderophore that bacteria use to scavenge iron and could serve as a targeting vector to image bacterial infection…”
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67Ga-labeled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes by Ioppolo, Joseph A., Caldwell, Deanna, Beiraghi, Omid, Llano, Lisset, Blacker, Megan, Valliant, John F., Berti, Paul J.

“…Deferoxamine (DFO) is a siderophore that bacteria use to scavenge iron and could serve as a targeting vector to image bacterial infection where current…”
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Transition State Analysis of Enolpyruvylshikimate 3‑Phosphate (EPSP) Synthase (AroA)-Catalyzed EPSP Hydrolysis by Lou, Meiyan, Burger, Steven K, Gilpin, Meghann E, Gawuga, Vivian, Capretta, Alfredo, Berti, Paul J

“…Proton transfer to carbon atoms is a significant catalytic challenge because of the large intrinsic energetic barrier and the frequently unfavorable…”
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Transition State Analysis of Acid-Catalyzed dAMP Hydrolysis by McCann, Joe A. B, Berti, Paul J

“…Multiple kinetic isotope effects (KIEs) on deoxyadenosine monophosphate (dAMP) hydrolysis in 0.1 M HCl were used to determine the transition state (TS)…”
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Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp by Jiang, Shan, Gilpin, Meghann E, Attia, Menat, Ting, Yi-Lee, Berti, Paul J

“…MurAs (enolpyruvyl-UDP-GlcNAc synthases) from pathogenic bacteria such as Borrelia burgdorferi (Lyme disease) and tuberculosis are fosfomycin resistant because…”
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