Search Results - "Berthiaume, Luc"

Glutathione transferase P1 is modified by palmitate by Marensi, Vanessa, Yap, Megan C, Ji, Yuhuan, Lin, Cheng, Berthiaume, Luc G, Leslie, Elaine M

“…Glutathione transferase P1 (GSTP1) is a multi-functional protein that protects cells from electrophiles by catalyzing their conjugation with glutathione, and…”
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Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: A meta-analysis by Bagshaw, Sean M, Berthiaume, Luc R, Delaney, Anthony, Bellomo, Rinaldo

“…OBJECTIVE:To appraise the literature on the effect of initial renal replacement therapy (RRT) modality on clinical outcomes. DESIGN:Systematic review and…”
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Palmitoylated TMX and calnexin target to the mitochondria-associated membrane by Lynes, Emily M, Bui, Michael, Yap, Megan C, Benson, Matthew D, Schneider, Bobbie, Ellgaard, Lars, Berthiaume, Luc G, Simmen, Thomas

“…The mitochondria‐associated membrane (MAM) is a domain of the endoplasmic reticulum (ER) that mediates the exchange of ions, lipids and metabolites between the…”
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Describing organ dysfunction in the intensive care unit: a cohort study of 20,000 patients by Soo, Andrea, Zuege, Danny J, Fick, Gordon H, Niven, Daniel J, Berthiaume, Luc R, Stelfox, Henry T, Doig, Christopher J

“…Multiple organ dysfunction is a common cause of morbidity and mortality in intensive care units (ICUs). Original development of the Sequential Organ Failure…”
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Post-translational myristoylation: Fat matters in cellular life and death by Martin, Dale D.O., Beauchamp, Erwan, Berthiaume, Luc G.

“…Myristoylation corresponds to the irreversible covalent linkage of the 14-carbon saturated fatty acid, myristic acid, to the N-terminal glycine of many…”
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Targeting N-myristoylation for therapy of B-cell lymphomas by Beauchamp, Erwan, Yap, Megan C., Iyer, Aishwarya, Perinpanayagam, Maneka A., Gamma, Jay M., Vincent, Krista M., Lakshmanan, Manikandan, Raju, Anandhkumar, Tergaonkar, Vinay, Tan, Soo Yong, Lim, Soon Thye, Dong, Wei-Feng, Postovit, Lynne M., Read, Kevin D., Gray, David W., Wyatt, Paul G., Mackey, John R., Berthiaume, Luc G.

“…Myristoylation, the N-terminal modification of proteins with the fatty acid myristate, is critical for membrane targeting and cell signaling. Because cancer…”
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Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling by Lynes, Emily M, Raturi, Arun, Shenkman, Marina, Ortiz Sandoval, Carolina, Yap, Megan C, Wu, Jiahui, Janowicz, Aleksandra, Myhill, Nathan, Benson, Matthew D, Campbell, Robert E, Berthiaume, Luc G, Lederkremer, Gerardo Z, Simmen, Thomas

“…The palmitoylation of calnexin serves to enrich calnexin on the mitochondria-associated membrane (MAM). Given a lack of information on the significance of this…”
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HIV-1 N-myristoylation-dependent hijacking of late endosomes/lysosomes to drive Gag assembly in macrophages by Guajardo-Contreras, Gabriel I, Dos-Santos, Ana L Abdalla, Chen, Alex, Niu, Meijuan, Beauchamp, Erwan, Berthiaume, Luc G, Cochane, Alan W, Mouland, Andrew J

“…Macrophages represent an important viral reservoir in HIV-1-infected individuals. Different from T cells, HIV-1 assembly in macrophages occurs at intracellular…”
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A first-in-human phase I trial of daily oral zelenirstat, a N-myristoyltransferase inhibitor, in patients with advanced solid tumors and relapsed/refractory B-cell lymphomas by Sangha, Randeep, Jamal, Rahima, Spratlin, Jennifer, Kuruvilla, John, Sehn, Laurie H., Beauchamp, Erwan, Weickert, Michael, Berthiaume, Luc G., Mackey, John R.

“…Myristoylation, the N-terminal addition of the fatty acid myristate to proteins, regulates membrane-bound signal transduction pathways important in cancer cell…”
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Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition by Beauchamp, Erwan, Gamma, Jay M, Cromwell, Christopher R, Moussa, Eman W, Pain, Rony, Kostiuk, Morris A, Acevedo-Morantes, Claudia, Iyer, Aishwarya, Yap, Megan, Vincent, Krista M, Postovit, Lynne M, Julien, Olivier, Hubbard, Basil P, Mackey, John R, Berthiaume, Luc G

“…In humans, two ubiquitously expressed N-myristoyltransferases, NMT1 and NMT2, catalyze myristate transfer to proteins to facilitate membrane targeting and…”
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Wnt acylation: seeing is believing by Berthiaume, Luc G

“…A highly original and sensitive method using clickable bioorthogonal fatty acids and in situ proximity ligation enables the visualization of the palmitoylation…”
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N-myristoyltransferase proteins in breast cancer: prognostic relevance and validation as a new drug target by Mackey, John R., Lai, Justine, Chauhan, Utkarsh, Beauchamp, Erwan, Dong, Wei-Feng, Glubrecht, Darryl, Sim, Yie-Wei, Ghosh, Sunita, Bigras, Gilbert, Lai, Raymond, Berthiaume, Luc G.

“…Purpose N -myristoyltransferases 1 and 2 (NMT1 and NMT2) catalyze the addition of 14-carbon fatty acids to the N-terminus of proteins. Myristoylation regulates…”
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Novel, First-in-Human, Oral PCLX-001 Treatment in a Patient with Relapsed Diffuse Large B-Cell Lymphoma by Sangha, Randeep, Davies, Neal M, Namdar, Afshin, Chu, Michael, Spratlin, Jennifer, Beauchamp, Erwan, Berthiaume, Luc G, Mackey, John R

“…Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) have limited treatment options, particularly if they are transplantation or chimeric…”
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N-myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum by Dudek, Elzbieta, Millott, Robyn, Liu, Wen-Xin, Beauchamp, Erwan, Berthiaume, Luc G., Michalak, Marek

“…Calnexin is a type 1 integral endoplasmic reticulum (ER) membrane molecular chaperone with a highly conserved C-terminal domain oriented to the cytoplasm…”
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Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE by Kostiuk, Morris A, Keller, Bernd O, Berthiaume, Luc G

“…Excessive liver production of ketone bodies is one of many metabolic complications that can arise from diabetes, and in severe untreated cases, it can result…”
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Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin by Martin, Dale D O, Heit, Ryan J, Yap, Megan C, Davidson, Michael W, Hayden, Michael R, Berthiaume, Luc G

“…Huntington disease (HD) is a debilitating neurodegenerative disease characterized by the loss of motor control and cognitive ability that ultimately leads to…”
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Membrane topology of human monoacylglycerol acyltransferase-2 and identification of regions important for its localization to the endoplasmic reticulum by McFie, Pamela J., Izzard, Sabrina, Vu, Huyen, Jin, Youzhi, Beauchamp, Erwan, Berthiaume, Luc G., Stone, Scot J.

“…Acyl CoA:2-monoacylglycerol acyltransferase (MGAT)-2 has an important role in dietary fat absorption in the intestine. MGAT2 resides in the endoplasmic…”
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Regulation of TRPP3 Channel Function by N-terminal Domain Palmitoylation and Phosphorylation by Zheng, Wang, Yang, JungWoo, Beauchamp, Erwan, Cai, Ruiqi, Hussein, Shaimaa, Hofmann, Laura, Li, Qiang, Flockerzi, Veit, Berthiaume, Luc G., Tang, Jingfeng, Chen, Xing-Zhen

“…Transient receptor potential polycystin-3 (TRPP3) is a cation channel activated by calcium and proton and is involved in hedgehog signaling, intestinal…”
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Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry[S] by Yap, Megan C., Kostiuk, Morris A., Martin, Dale D.O., Perinpanayagam, Maneka A., Hak, Pieter G., Siddam, Anjaiah, Majjigapu, Janaki R., Rajaiah, Gurram, Keller, Bernd O., Prescher, Jennifer A., Wu, Peng, Bertozzi, Carolyn R., Falck, John R., Berthiaume, Luc G.

“…Progress in understanding the biology of protein fatty acylation has been impeded by the lack of rapid direct detection and identification methods. We first…”
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Cationic polymer‐mediated small interfering RNA delivery for P‐glycoprotein down‐regulation in tumor cells by Abbasi, Meysam, Lavasanifar, Afsaneh, Berthiaume, Luc G., Weinfeld, Michael, Uludağ, Hasan

“…BACKGROUND: Among the treatment options that have been developed for cancer, chemotherapy remains 1 of the leading clinical approaches. Chemotherapy can…”
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