Search Results - "Berthele, Achim"

Adverse Events in NMOSD Therapy by Giglhuber, Katrin, Berthele, Achim

“…Neuromyelitis optica spectrum disorders (NMOSD) are rare neurologic autoimmune diseases that have a poor prognosis if left untreated. For many years, generic…”
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Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder by Pittock, Sean J, Berthele, Achim, Fujihara, Kazuo, Kim, Ho Jin, Levy, Michael, Palace, Jacqueline, Nakashima, Ichiro, Terzi, Murat, Totolyan, Natalia, Viswanathan, Shanthi, Wang, Kai-Chen, Pace, Amy, Fujita, Kenji P, Armstrong, Róisín, Wingerchuk, Dean M

“…Neuromyelitis optica spectrum disorder is a relapsing inflammatory disorder of the central nervous system. Two thirds of patients have antibodies against…”
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The role of intrathecal free light chains kappa for the detection of autoimmune encephalitis in subacute onset neuropsychiatric syndromes by Bertram, Dominic, Tsaktanis, Thanos, Berthele, Achim, Korn, Thomas

“…Intrathecal synthesis of free light chains kappa (FLCK) is increasingly recognized as a marker of inflammatory CNS pathologies. Here, we tested the performance…”
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An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis by Schmidt, Paul, Gaser, Christian, Arsic, Milan, Buck, Dorothea, Förschler, Annette, Berthele, Achim, Hoshi, Muna, Ilg, Rüdiger, Schmid, Volker J., Zimmer, Claus, Hemmer, Bernhard, Mühlau, Mark

“…In Multiple Sclerosis (MS), detection of T2-hyperintense white matter (WM) lesions on magnetic resonance imaging (MRI) has become a crucial criterion for…”
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Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS) by Trebst, Corinna, Jarius, Sven, Berthele, Achim, Paul, Friedemann, Schippling, Sven, Wildemann, Brigitte, Borisow, Nadja, Kleiter, Ingo, Aktas, Orhan, Kümpfel, Tania

“…Neuromyelitis optica (NMO, Devic’s syndrome), long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity. Major…”
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Simultaneous Quantification and Speciation of Trace Metals in Paired Serum and CSF Samples by Size Exclusion Chromatography-Inductively Coupled Plasma-Dynamic Reaction Cell-Mass Spectrometry (SEC-DRC-ICP-MS) by Michalke, Bernhard, Berthele, Achim, Venkataramani, Vivek

“…Transition metals play a crucial role in brain metabolism: since they exist in different oxidation states they are involved in ROS generation, but they are…”
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Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases by Lepennetier, Gildas, Hracsko, Zsuzsanna, Unger, Marina, Van Griensven, Martijn, Grummel, Verena, Krumbholz, Markus, Berthele, Achim, Hemmer, Bernhard, Kowarik, Markus C

“…Cytokines play multiple roles during neuro-inflammatory processes and several cytokines have been studied in the context of specific diseases. This study…”
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CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation by Kowarik, Markus C, Cepok, Sabine, Sellner, Johann, Grummel, Verena, Weber, Martin S, Korn, Thomas, Berthele, Achim, Hemmer, Bernhard

“…The chemokines and cytokines CXCL13, CXCL12, CCL19, CCL21, BAFF and APRIL are believed to play a role in the recruitment of B cells to the central nervous…”
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Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses by Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Wegner, Brigitte, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Krumbholz, Markus, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Winkelmann, Alexander, Marouf, Wael, Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, Trebst, Corinna

“…Objective Neuromyelitis optica (NMO) attacks often are severe, are difficult to treat, and leave residual deficits. Here, we analyzed the frequency, sequence,…”
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Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis by Srivastava, Rajneesh, Aslam, Muhammad, Kalluri, Sudhakar Reddy, Schirmer, Lucas, Buck, Dorothea, Tackenberg, Björn, Rothhammer, Veit, Chan, Andrew, Gold, Ralf, Berthele, Achim, Bennett, Jeffrey L, Korn, Thomas, Hemmer, Bernhard

“…Evidence suggests that B cells and antibodies contribute to multiple sclerosis (MS) in a subgroup of affected persons. The authors of this study implicate the…”
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Selenium speciation in paired serum and cerebrospinal fluid samples by Solovyev, Nikolay, Berthele, Achim, Michalke, Bernhard

“…Se speciation was performed in 24 individual paired serum and cerebrospinal fluid (CSF) samples from neurologically healthy persons. Strong anion exchange…”
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Eculizumab monotherapy for NMOSD: Data from PREVENT and its open-label extension by Pittock, Sean J, Fujihara, Kazuo, Palace, Jacqueline, Berthele, Achim, Kim, Ho Jin, Oreja-Guevara, Celia, Nakashima, Ichiro, Levy, Michael, Shang, Shulian, Yountz, Marcus, Miller, Larisa, Armstrong, Róisín, Wingerchuk, Dean M

“…During PREVENT (a phase 3, randomized, double-blind, placebo-controlled, time-to-event study) and its open-label extension (interim analysis), 33 adults with…”
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Cortical pathology in multiple sclerosis detected by the T1/T2‐weighted ratio from routine magnetic resonance imaging by Righart, Ruthger, Biberacher, Viola, Jonkman, Laura E., Klaver, Roel, Schmidt, Paul, Buck, Dorothea, Berthele, Achim, Kirschke, Jan S., Zimmer, Claus, Hemmer, Bernhard, Geurts, Jeroen J. G., Mühlau, Mark

“…Objective In multiple sclerosis, neuropathological studies have shown widespread changes in the cerebral cortex. In vivo imaging is critical, because the…”
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Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders by Aly, Lilian, Strauß, Eva-Maria, Feucht, Nikolaus, Weiß, Isabella, Berthele, Achim, Mitsdoerffer, Meike, Haass, Christian, Hemmer, Bernhard, Maier, Mathias, Korn, Thomas, Knier, Benjamin

“…Background: Neuromyelitis optica spectrum disorders (NMOSD) are neuroinflammatory diseases of the central nervous system. Patients suffer from recurring…”
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The impact of disease-modifying therapies on immunoglobulin blood levels in patients with multiple sclerosis: a retrospective cross-sectional study by Klein, Ana, Flaskamp, Martina, Berthele, Achim, Held, Friederike, Muratovic, Harisa, Hemmer, Bernhard

“…Background: Although disease-modifying therapies (DMTs) in multiple sclerosis (MS) are known to target the immune system, mechanisms of action, efficacy,…”
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Cognitive impairment in early MS: contribution of white matter lesions, deep grey matter atrophy, and cortical atrophy by Engl, Christina, Tiemann, Laura, Grahl, Sophia, Bussas, Matthias, Schmidt, Paul, Pongratz, Viola, Berthele, Achim, Beer, Annkathrin, Gaser, Christian, Kirschke, Jan S., Zimmer, Claus, Hemmer, Bernhard, Mühlau, Mark

“…Background Cognitive impairment (CI) is a frequent and debilitating symptom in MS. To better understand the neural bases of CI in MS, this magnetic resonance…”
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Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients by Held, Friederike, Kalluri, Sudhakar Reddy, Berthele, Achim, Klein, Ana-Katharina, Reindl, Markus, Hemmer, Bernhard

“…Background Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOG-AD) is recognized as a distinct nosological entity. IgG antibodies against MOG…”
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Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study by Bittner, Stefan, Steffen, Falk, Uphaus, Timo, Muthuraman, Muthuraman, Fleischer, Vinzenz, Salmen, Anke, Luessi, Felix, Berthele, Achim, Klotz, Luisa, Meuth, Sven G., Bayas, Antonios, Paul, Friedemann, Hartung, Hans-Peter, Linker, Ralf, Heesen, Christoph, Stangel, Martin, Wildemann, Brigitte, Then Bergh, Florian, Tackenberg, Björn, Kuempfel, Tania, Weber, Frank, Zettl, Uwe K., Ziemann, Ulf, Tumani, Hayrettin, Groppa, Sergiu, Mühlau, Mark, Lukas, Carsten, Hemmer, Bernhard, Wiendl, Heinz, Gold, Ralf, Zipp, Frauke

“…We aim to evaluate serum neurofilament light chain (sNfL), indicating neuroaxonal damage, as a biomarker at diagnosis in a large cohort of early multiple…”
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Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers by Bussas, Matthias, Grahl, Sophia, Pongratz, Viola, Berthele, Achim, Gasperi, Christiane, Andlauer, Till, Gaser, Christian, Kirschke, Jan S, Wiestler, Benedikt, Zimmer, Claus, Hemmer, Bernhard, Mühlau, Mark

“…Background: Lesions of brain white matter (WM) and atrophy of brain gray matter (GM) are well-established surrogate parameters in multiple sclerosis (MS), but…”
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Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG–Associated Disease and Neuromyelitis Optica Spectrum Disorders by Ringelstein, Marius, Ayzenberg, Ilya, Lindenblatt, Gero, Fischer, Katinka, Gahlen, Anna, Novi, Giovanni, Hayward-Könnecke, Helen, Schippling, Sven, Rommer, Paulus S., Kornek, Barbara, Zrzavy, Tobias, Biotti, Damien, Ciron, Jonathan, Audoin, Bertrand, Berthele, Achim, Giglhuber, Katrin, Zephir, Helene, Kümpfel, Tania, Berger, Robert, Röther, Joachim, Häußler, Vivien, Stellmann, Jan-Patrick, Whittam, Daniel, Jacob, Anu, Kraemer, Markus, Gueguen, Antoine, Deschamps, Romain, Bayas, Antonios, Hümmert, Martin W., Trebst, Corinna, Haarmann, Axel, Jarius, Sven, Wildemann, Brigitte, Grothe, Matthias, Siebert, Nadja, Ruprecht, Klemens, Paul, Friedemann, Collongues, Nicolas, Marignier, Romain, Levy, Michael, Karenfort, Michael, Deppe, Michael, Albrecht, Philipp, Hellwig, Kerstin, Gold, Ralf, Hartung, Hans-Peter, Meuth, Sven G., Kleiter, Ingo, Aktas, Orhan

“…To evaluate the long-term safety and efficacy of tocilizumab (TCZ), a humanized anti-interleukin-6 receptor antibody in myelin oligodendrocyte…”
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