Search Results - "Bert, Marc Le"

Targeted autophagy disruption reveals the central role of macrophage iron metabolism in systemic iron homeostasis by Taleb, Meriem, Maillet, Isabelle, Le Bert, Marc Le, Mura, Catherine

“…Iron homeostasis depends on both intracellular control through iron-responsive proteins and the systemic level of iron through hepcidin-ferroportin axis…”
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The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin by Fanny, Manoussa, Nascimento, Mégane, Baron, Ludivine, Schricke, Corinne, Maillet, Isabelle, Akbal, Myriam, Riteau, Nicolas, Le Bert, Marc, Quesniaux, Valérie, Ryffel, Bernhard, Gombault, Aurélie, Même, Sandra, Même, William, Couillin, Isabelle

“…Idiopathic pulmonary fibrosis is a progressive, devastating, and yet untreatable fibrotic disease of unknown origin. Interleukin-33 (IL-33), an IL-1 family…”
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B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure by Nascimento, Mégane, Huot-Marchand, Sarah, Gombault, Aurélie, Panek, Corinne, Bourinet, Manon, Fanny, Manoussa, Savigny, Florence, Schneider, Pascal, Le Bert, Marc, Ryffel, Bernhard, Riteau, Nicolas, Quesniaux, Valérie F J, Couillin, Isabelle

“…Cigarette smoke (CS) is the major cause of chronic lung injuries, such as chronic obstructive pulmonary disease (COPD). In patients with severe COPD, tertiary…”
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Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection by Palomo, Jennifer, Marchiol, Tiffany, Piotet, Julie, Fauconnier, Louis, Robinet, Marieke, Reverchon, Flora, Le Bert, Marc, Togbe, Dieudonnée, Buijs-Offerman, Ruvalic, Stolarczyk, Marta, Quesniaux, Valérie F J, Scholte, Bob J, Ryffel, Bernhard

“…Cystic fibrosis is associated with increased inflammatory responses to pathogen challenge. Here we revisited the role of IL-1β in lung pathology using the…”
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Relative contribution of IL‐1α, IL‐1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG by Bourigault, Marie‐Laure, Segueni, Noria, Rose, Stéphanie, Court, Nathalie, Vacher, Rachel, Vasseur, Virginie, Erard, François, Le Bert, Marc, Garcia, Irene, Iwakura, Yoichiro, Jacobs, Muazzam, Ryffel, Bernhard, Quesniaux, Valerie F. J.

“…TNF and IL‐1 are major mediators involved in severe inflammatory diseases against which therapeutic neutralizing antibodies are developed. However, both TNF…”
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STING-dependent sensing of self-DNA drives silica-induced lung inflammation by Benmerzoug, Sulayman, Rose, Stéphanie, Bounab, Badreddine, Gosset, David, Duneau, Laure, Chenuet, Pauline, Mollet, Lucile, Le Bert, Marc, Lambers, Christopher, Geleff, Silvana, Roth, Michael, Fauconnier, Louis, Sedda, Delphine, Carvalho, Clarisse, Perche, Olivier, Laurenceau, David, Ryffel, Bernhard, Apetoh, Lionel, Kiziltunc, Ahmet, Uslu, Hakan, Albez, Fadime Sultan, Akgun, Metin, Togbe, Dieudonnée, Quesniaux, Valerie F. J.

“…Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung…”
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PD-1 Is Involved in the Dysregulation of Type 2 Innate Lymphoid Cells in a Murine Model of Obesity by Oldenhove, Guillaume, Boucquey, Elodie, Taquin, Anaelle, Acolty, Valérie, Bonetti, Lynn, Ryffel, Bernhard, Le Bert, Marc, Englebert, Kevin, Boon, Louis, Moser, Muriel

“…Recent observations clearly highlight the critical role of type 2 innate lymphoid cells in maintaining the homeostasis of adipose tissues in humans and mice…”
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Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice by Nascimento, Mégane, Gombault, Aurélie, Lacerda-Queiroz, Norinne, Panek, Corinne, Savigny, Florence, Sbeity, Malak, Bourinet, Manon, Le Bert, Marc, Riteau, Nicolas, Ryffel, Bernhard, Quesniaux, Valérie F. J., Couillin, Isabelle

“…Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with…”
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Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns by Vasile, Flora, Dossi, Elena, Moulard, Julien, Ezan, Pascal, Lecoin, Laure, Cohen-Salmon, Martine, Mailly, Philippe, Le Bert, Marc, Couillin, Isabelle, Bemelmans, Alexis, Rouach, Nathalie

“…Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive…”
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Aryl hydrocarbon receptor (Ahr)‐dependent Il‐22 expression by type 3 innate lymphoid cells control of acute joint inflammation by Nehmar, Ramzi, Fauconnier, Louis, Alves‐Filho, Jose, Togbe, Dieudonnée, DeCauwer, Aurore, Bahram, Seiamak, Le Bert, Marc, Ryffel, Bernhard, Georgel, Philippe

“…The aryl hydrocarbon receptor (AHR) controls several inflammatory and metabolic pathways involved in various diseases, including the development of arthritis…”
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IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis by Gasse, Paméla, Riteau, Nicolas, Vacher, Rachel, Michel, Marie-Laure, Fautrel, Alain, di Padova, Franco, Fick, Lizette, Charron, Sabine, Lagente, Vincent, Eberl, Gérard, Le Bert, Marc, Quesniaux, Valérie F J, Huaux, François, Leite-de-Moraes, Maria, Ryffel, Bernhard, Couillin, Isabelle

“…Idiopathic pulmonary fibrosis is a devastating as yet untreatable disease. We demonstrated recently the predominant role of the NLRP3 inflammasome activation…”
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Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent by Doz, Emilie, Noulin, Nicolas, Boichot, Elisabeth, Guenon, Isabelle, Fick, Lizette, Le Bert, Marc, Lagente, Vincent, Ryffel, Bernhard, Schnyder, Bruno, Quesniaux, Valerie F. J, Couillin, Isabelle

“…Acute cigarette smoke exposure of the airways (two cigarettes twice daily for three days) induces acute inflammation in mice. In this study, we show that…”
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Inducible CTCF insulator delays the IgH 3′ regulatory region-mediated activation of germline promoters and alters class switching by Braikia, Fatima-Zohra, Oudinet, Chloé, Haddad, Dania, Oruc, Zeliha, Orlando, Domenico, Dauba, Audrey, LeBert, Marc, Khamlichi, Ahmed Amine

“…Class switch recombination (CSR) plays an important role in adaptive immune response by enabling mature B cells to switch from IgM expression to the expression…”
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Lung inflammation and interstitial fibrosis by targeted alveolar epithelial type I cell death by Carignon, Sandra, De Moura Rodrigues, Dorian, Gosset, David, Culerier, Elodie, Huot-Marchand, Sarah, Savigny, Florence, Kaya, Eric, Quesniaux, Valerie, Gombault, Aurélie, Couillin, Isabelle, Ryffel, Bernhard, Le Bert, Marc, Riteau, Nicolas

“…IntroductionThe pathogenesis of chronic lung diseases is multifaceted with a major role of recurrent micro-injuries of the epithelium. While several reports…”
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Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3 by Huot-Marchand, Sarah, Nascimento, Mégane, Culerier, Elodie, Bourenane, Mélissa, Savigny, Florence, Panek, Corinne, Serdjebi, Cindy, Le Bert, Marc, Quesniaux, Valérie F J, Ryffel, Bernhard, Broz, Petr, Riteau, Nicolas, Gombault, Aurélie, Couillin, Isabelle

“…Chronic pulmonary inflammation and chronic obstructive pulmonary disease (COPD) are major health issues largely due to air pollution and cigarette smoke (CS)…”
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Protein kinase Cθ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen by Madouri, Fahima, Chenuet, Pauline, Beuraud, Chloé, Fauconnier, Louis, Marchiol, Tiffany, Rouxel, Nathalie, Ledru, Aurélie, Gallerand, Margaux, Lombardi, Vincent, Mascarell, Laurent, Marquant, Quentin, Apetoh, Lionel, Erard, François, Le Bert, Marc, Trovero, Fabrice, Quesniaux, Valérie F.J., Ryffel, Bernhard, Togbe, Dieudonnée

“…Protein kinase C (PKC) θ, a serine/threonine kinase, is involved in TH2 cell activation and proliferation. Type 2 innate lymphoid cells (ILC2s) resemble TH2…”
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Protective Role of the Nucleic Acid Sensor STING in Pulmonary Fibrosis by Savigny, Florence, Schricke, Corinne, Lacerda-Queiroz, Norinne, Meda, Mélanie, Nascimento, Mégane, Huot-Marchand, Sarah, Da Gama Monteiro, Felipe, Ryffel, Bernhard, Gombault, Aurélie, Le Bert, Marc, Couillin, Isabelle, Riteau, Nicolas

“…Idiopathic pulmonary fibrosis (IPF) is the most common and severe type of interstitial lung disease for which current treatments display limited efficacy. IPF…”
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The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice by Secher, Thomas, Maillet, Isabelle, Mackowiak, Claire, Le Bérichel, Jessica, Philippeau, Amandine, Panek, Corinne, Boury, Michèle, Oswald, Eric, Saoudi, Abdelhadi, Erard, Francois, Le Bert, Marc, Quesniaux, Valérie, Couturier-Maillard, Aurélie, Ryffel, Bernhard

“…Allergic asthma is characterized by a strong Th2 and Th17 response with inflammatory cell recruitment, airways hyperreactivity and structural changes in the…”
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Complete cis Exclusion upon Duplication of the Eμ Enhancer at the Immunoglobulin Heavy Chain Locus by Puget, Nadine, Leduc, Claire, Oruc, Zéliha, Moutahir, Mohammed, Le Bert, Marc, Khamlichi, Ahmed Amine

“…Developing lymphocytes somatically diversify their antigen-receptor loci through V(D)J recombination. The process is associated with allelic exclusion, which…”
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NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner by Nascimento, Mégane, Huot-Marchand, Sarah, Fanny, Manoussa, Straube, Marjolène, Le Bert, Marc, Savigny, Florence, Apetoh, Lionel, Van Snick, Jacques, Trovero, Fabrice, Chamaillard, Mathias, Quesniaux, Valérie F J, Ryffel, Bernhard, Gosset, Philippe, Gombault, Aurélie, Riteau, Nicolas, Sokol, Harry, Couillin, Isabelle

“…Chronic obstructive pulmonary disease (COPD) is a major health issue primarily caused by cigarette smoke (CS) and characterized by breathlessness and repeated…”
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