Search Results - "Bersuker, Kirill"

Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation by Bersuker, Kirill, Olzmann, James A.

“…Lipid droplets (LDs) are ubiquitous, endoplasmic reticulum (ER)-derived organelles that mediate the sequestration of neutral lipids (e.g. triacylglycerol and…”
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis by Bersuker, Kirill, Hendricks, Joseph M., Li, Zhipeng, Magtanong, Leslie, Ford, Breanna, Tang, Peter H., Roberts, Melissa A., Tong, Bingqi, Maimone, Thomas J., Zoncu, Roberto, Bassik, Michael C., Nomura, Daniel K., Dixon, Scott J., Olzmann, James A.

“…Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids 1 , 2 . The glutathione-dependent lipid…”
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Protein misfolding specifies recruitment to cytoplasmic inclusion bodies by Bersuker, Kirill, Brandeis, Michael, Kopito, Ron R

“…Inclusion bodies (IBs) containing aggregated disease-associated proteins and polyubiquitin (poly-Ub) conjugates are universal histopathological features of…”
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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease by Hipp, Mark S, Patel, Chetan N, Bersuker, Kirill, Riley, Brigit E, Kaiser, Stephen E, Shaler, Thomas A, Brandeis, Michael, Kopito, Ron R

“…Pathognomonic accumulation of ubiquitin (Ub) conjugates in human neurodegenerative diseases, such as Huntington's disease, suggests that highly aggregated…”
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Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response by Ben Yehuda, Adi, Risheq, Marwa, Novoplansky, Ofra, Bersuker, Kirill, Kopito, Ron R, Goldberg, Michal, Brandeis, Michael

“…Deposition of ubiquitin conjugates on inclusion bodies composed of protein aggregates is a definitive cytopathological hallmark of neurodegenerative diseases…”
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In Close Proximity: The Lipid Droplet Proteome and Crosstalk With the Endoplasmic Reticulum by Bersuker, Kirill, Olzmann, James A.

“…Lipid droplets (LDs) are conserved, endoplasmic reticulum (ER)-derived organelles that act as a dynamic cellular repository for neutral lipids. Numerous…”
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A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes by Bersuker, Kirill, Peterson, Clark W.H., To, Milton, Sahl, Steffen J., Savikhin, Victoria, Grossman, Elizabeth A., Nomura, Daniel K., Olzmann, James A.

“…Lipid droplet (LD) functions are regulated by a complement of integral and peripheral proteins that associate with the bounding LD phospholipid monolayer…”
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Identification of Lipid Droplet Proteomes by Proximity Labeling Proteomics Using APEX2 by Bersuker, Kirill, Olzmann, James A

“…Lipid droplets (LDs) are ubiquitous lipid storage organelles composed of a neutral lipid core surrounded by a phospholipid monolayer that is decorated with…”
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Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis by Hendricks, Joseph M, Doubravsky, Cody E, Wehri, Eddie, Li, Zhipeng, Roberts, Melissa A, Deol, Kirandeep K, Lange, Mike, Lasheras-Otero, Irene, Momper, Jeremiah D, Dixon, Scott J, Bersuker, Kirill, Schaletzky, Julia, Olzmann, James A

“…Ferroptosis is a regulated form of cell death associated with the iron-dependent accumulation of phospholipid hydroperoxides. Inducing ferroptosis is a…”
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Protein misfolding specifies recruitment to cytoplasmic inclusion bodies by Bersuker, Kirill, Brandeis, Michael, Kopito, Ron R.

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Heat Shock Response Activation Exacerbates Inclusion Body Formation in a Cellular Model of Huntington Disease by Bersuker, Kirill, Hipp, Mark S., Calamini, Barbara, Morimoto, Richard I., Kopito, Ron R.

“…The cellular heat shock response (HSR) protects cells from toxicity associated with defective protein folding, and this pathway is widely viewed as a potential…”
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Misfolding, Not Ubiquitylation, Underlies Protein Targeting to Inclusion Bodies by Bersuker, Kirill

“…Inclusion bodies (IB) containing aggregated forms of disease-associated proteins and polyubiquitin conjugates are universal histopathological features of…”
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AP180-mediated trafficking of Vamp7B limits homotypic fusion of Dictyostelium contractile vacuoles by Wen, Yujia, Stavrou, Irene, Bersuker, Kirill, Brady, Rebecca J, De Lozanne, Arturo, O'Halloran, Theresa J

“…Clathrin-coated vesicles play an established role in endocytosis from the plasma membrane, but they are also found on internal organelles. We examined the…”
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Live-cell imaging of ubiquitin-proteasome system function by Hipp, Mark S, Bersuker, Kirill, Kopito, Ron R

“…The role of the ubiquitin-proteasome system (UPS) in maintaining protein homeostasis has generated a demand for assays that quantify UPS function in the…”
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