Search Results - "Berroyer, Alexandra"
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Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming Sequence
Published in Genetics (Austin) (01-12-2020)“…Abstract A significant increase in genome instability is associated with the conformational shift of a guanine-run-containing DNA strand into the four-stranded…”
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The activity of yeast Apn2 AP endonuclease at uracil-derived AP sites is dependent on the major carbon source
Published in Current genetics (01-04-2021)“…Yeast Apn2 is an AP endonuclease and DNA 3′-diesterase that belongs to the Exo III family with homology to the E. coli exonuclease III, Schizosaccharomyces…”
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Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop ‘G4 Kissing’ interaction
Published in Nucleic acids research (19-06-2020)“…Abstract Mammalian antibody switch regions (∼1500 bp) are composed of a series of closely neighboring G4-capable sequences. Whereas numerous structural and…”
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Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability
Published in Microbial cell (07-03-2022)“…Topoisomerase 1 (Top1) removes transcription-associated helical stress to suppress G4-formation and its induced recombination at genomic loci containing…”
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The Functional Consequences of Eukaryotic Topoisomerase 1 Interaction with G-Quadruplex DNA
Published in Genes (12-02-2020)“…Topoisomerase I in eukaryotic cells is an important regulator of DNA topology. Its catalytic function is to remove positive or negative superhelical tension by…”
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Response of Sulfolobus solfataricus Dpo4 polymerase in vitro to a DNA G-quadruplex
Published in Mutagenesis (20-09-2019)“…Repetitive DNA sequences support the formation of structures that can interrupt replication and repair, leading to breaks and mutagenesis. One particularly…”
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Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming Sequence
Published in Genetics (Austin) (01-12-2020)“…A significant increase in genome instability is associated with the conformational shift of a guanine-run-containing DNA strand into the four-stranded…”
Get full text
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Identification and stacking of crucial traits required for the domestication of pennycress
Published in Nature food (01-01-2020)Get full text
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Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro
Published in Frontiers in genetics (11-05-2015)“…The formation of highly stable four-stranded DNA, called G-quadruplex (G4), promotes site-specific genome instability. G4 DNA structures fold from repetitive…”
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Translesion synthesis of G-quadruplex DNA structures
Published 01-01-2016“…G-quadruplex (G4 DNA) structures are formed from repetitive guanine sequences, and such loci are common in the human genome. Increasing evidence suggests that…”
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Dissertation