Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina

Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little i...

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Published in:	PloS one Vol. 15; no. 7; p. e0233808
Main Authors:	Luisi, Pierre, García, Angelina, Berros, Juan Manuel, Motti, Josefina M. B, Demarchi, Darío A, Alfaro, Emma, Aquilano, Eliana, Argüelles, Carina, Avena, Sergio, Bailliet, Graciela, Beltramo, Julieta, Bravi, Claudio M, Cuello, Mariela, Dejean, Cristina, Dipierri, José Edgardo, Jurado Medina, Laura S, Lanata, José Luis, Muzzio, Marina, Parolin, María Laura, Pauro, Maia, Paz Sepúlveda, Paula B, Rodríguez Golpe, Daniela, Santos, María Rita, Schwab, Marisol, Silvero, Natalia, Zubrzycki, Jeremias, Ramallo, Virginia, Dopazo, Hernán, Calafell, Francesc
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 16-07-2020 Public Library of Science (PLoS)
Subjects:	Analysis Argentines Biology and Life Sciences Earth Sciences Emigration and immigration Foxes Genealogy Genetic aspects Genomic analysis Genotyping Hybridization Immigration Minority & ethnic groups Noncitizens Origins People and places Physical Sciences Population genetics Population structure Populations Research and Analysis Methods Tropical forests Argentina
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Summary:	Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: PL provides consulting services to myDNAmap S.L. JMB and JZ are employed by Biocódices S.A. HD is the scientific director of Biocódices S.A. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0233808