SCH 58450, a novel farnesyl protein transferase inhibitor possessing a 6a,12a:7,12-diepoxybenz[a]anthracene ring system

SCH 58450, a novel farnesyl protein transferase inhibitor possessing a 6a,12a:7,12-diepoxybenz[a]anthracene ring system

SCH 58450, a novel secondary metabolite possessing the 6a,12a:7,12.diepoxybenz[a]anthracene ring system, has been isolated from a Streptomyces sp. SCH 58450 inhibits farnesyl protein transferase with an IC 50 of 29 μM, and shows 25 fold selectivity for farnesyl protein transferase over geranylgerany...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 36; no. 39; pp. 6995 - 6998
Main Authors: Phife, David W., Patton, Robert W., Berrie, Raymond L., Yarborough, Raymond, Puar, Mohindar S., Patel, Mahesh, Bishop, W. Robert, Coval, Stephen J.
Format: Journal Article
Language:English
Published: Elsevier Ltd 25-09-1995
Online Access:Get full text
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Summary:SCH 58450, a novel secondary metabolite possessing the 6a,12a:7,12.diepoxybenz[a]anthracene ring system, has been isolated from a Streptomyces sp. SCH 58450 inhibits farnesyl protein transferase with an IC 50 of 29 μM, and shows 25 fold selectivity for farnesyl protein transferase over geranylgeranyl protein transferase-1.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)01589-A