Search Results - "Berra, Carolina Maria"
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Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue
Published in Free radical biology & medicine (01-08-2013)“…The nucleotide excision repair (NER) mechanism is well known to be involved in the removal of UV-induced lesions. Nevertheless, the involvement of this pathway…”
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Sustained kidney biochemical derangement in treated experimental diabetes: a clue to metabolic memory
Published in Scientific reports (12-01-2017)“…The occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing…”
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Plasmid DNA damage induced by singlet molecular oxygen released from the naphthalene endoperoxide DHPNO2 and photoactivated methylene blue
Published in Química nova (2010)“…To investigate oxidative lesions and strand breaks induction by singlet molecular oxygen (¹O2), supercoiled-DNA plasmid was treated with thermo-dissociated…”
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Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell
Published in Molecular and cellular biochemistry (01-04-2016)“…During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this…”
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New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X
Published in Scientific reports (10-07-2019)“…EPNs comprise a heterogeneous group of neuroepithelial tumors, accounting for about 10% of all intracranial tumors in children and up to 30% of brain tumors in…”
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Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model
Published in Oncotarget (20-09-2016)“…Renal cell carcinoma (RCC), also called kidney cancer or renal adenocarcinoma, is highly resistant to current treatments. It has been previously reported that…”
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Ligand-based design, synthesis, and experimental evaluation of novel benzofuroxan derivatives as anti-Trypanosoma cruzi agents
Published in European journal of medicinal chemistry (01-06-2013)“…A set of substituted-[N′-(benzofuroxan-5-yl)methylene]benzohydrazides (4a–t), previously designed and synthesized, was experimentally assayed against…”
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8
A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production
Published in Investigational new drugs (01-06-2013)“…Summary In cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2…”
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Apoptotic signaling of the Amblyomin‐X involves endoplasmic reticulum stress, cell cycle regulation and survival pathways
Published in The FASEB journal (01-04-2012)“…Abstract only The Amblyomin‐X, a Kunitz‐type inhibitor obtained in a recombinant protein form, promotes apoptosis in murine renal adenocarcinoma (RENCA),…”
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10
Rational development of a novel TFPI-like inhibitor from Amblyomma cajennense tick
Published in Toxin reviews (01-03-2014)“…Abstract Hematophagous organisms have been described to possess specific blood coagulation inhibitors with different structures and novel mechanism of action…”
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