Search Results - "Bernt, Kathrin M."

Rethinking paraneoplastic eosinophilia by Bernt, Kathrin M

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Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor by Daigle, Scott R., Olhava, Edward J., Therkelsen, Carly A., Majer, Christina R., Sneeringer, Christopher J., Song, Jeffrey, Johnston, L. Danielle, Scott, Margaret Porter, Smith, Jesse J., Xiao, Yonghong, Jin, Lei, Kuntz, Kevin W., Chesworth, Richard, Moyer, Mikel P., Bernt, Kathrin M., Tseng, Jen-Chieh, Kung, Andrew L., Armstrong, Scott A., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M.

“…Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in mixed lineage leukemia (MLL). The characterization of EPZ004777, a…”
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Chromatin-modifying enzymes as modulators of reprogramming by Onder, Tamer T., Kara, Nergis, Cherry, Anne, Sinha, Amit U., Zhu, Nan, Bernt, Kathrin M., Cahan, Patrick, Mancarci, B. Ogan, Unternaehrer, Juli, Gupta, Piyush B., Lander, Eric S., Armstrong, Scott A., Daley, George Q.

“…Inhibition of DOT1L, the H3K79 histone methyltransferase, increases cell reprogramming and substituted for KLF4 and c-Myc, showing that chromatin-modifying…”
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Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia by Bernt, Kathrin M, Hunger, Stephen P

“…The t(9;22)(q34;q11) or Philadelphia chromosome creates a BCR-ABL1 fusion gene encoding for a chimeric BCR-ABL1 protein. It is present in 3-4% of pediatric…”
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AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes by Deshpande, Aniruddha J., Deshpande, Anagha, Sinha, Amit U., Chen, Liying, Chang, Jenny, Cihan, Ali, Fazio, Maurizio, Chen, Chun-wei, Zhu, Nan, Koche, Richard, Dzhekieva, Liuda, Ibáñez, Gloria, Dias, Stuart, Banka, Deepti, Krivtsov, Andrei, Luo, Minkui, Roeder, Robert G., Bradner, James E., Bernt, Kathrin M., Armstrong, Scott A.

“…Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted…”
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HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas by Xie, Hongbo M., Bernt, Kathrin M.

“…Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48…”
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Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML by Riedel, Simone S., Lu, Congcong, Xie, Hongbo M., Nestler, Kevin, Vermunt, Marit W., Lenard, Alexandra, Bennett, Laura, Speck, Nancy A., Hanamura, Ichiro, Lessard, Julie A., Blobel, Gerd A., Garcia, Benjamin A., Bernt, Kathrin M.

“…Meningioma-1 (MN1) overexpression in AML is associated with poor prognosis, and forced expression of MN1 induces leukemia in mice. We sought to determine how…”
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Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l by Deshpande, Aniruddha J., Chen, Liying, Fazio, Maurizio, Sinha, Amit U., Bernt, Kathrin M., Banka, Deepti, Dias, Stuart, Chang, Jenny, Olhava, Edward J., Daigle, Scott R., Richon, Victoria M., Pollock, Roy M., Armstrong, Scott A.

“…The t(6;11)(q27;q23) is a recurrent chromosomal rearrangement that encodes the MLLAF6 fusion oncoprotein and is observed in patients with diverse hematologic…”
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CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma by Pascual-Pasto, Guillem, McIntyre, Brendan, Hines, Margaret G., Giudice, Anna M., Garcia-Gerique, Laura, Hoffmann, Jennifer, Mishra, Pamela, Matlaga, Stephanie, Lombardi, Simona, Shraim, Rawan, Schürch, Patrick M., Yarmarkovich, Mark, Hofmann, Ted J., Alikarami, Fatemeh, Martinez, Daniel, Tsang, Matthew, Gil-de-Gómez, Luis, Spear, Timothy T., Bernt, Kathrin M., Wolpaw, Adam J., Dimitrov, Dimiter S., Li, Wei, Bosse, Kristopher R.

“…Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive…”
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Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia by Danis, Etienne, Yamauchi, Taylor, Echanique, Kristen, Zhang, Xi, Haladyna, Jessica N., Riedel, Simone S., Zhu, Nan, Xie, Huafeng, Orkin, Stuart H., Armstrong, Scott A., Bernt, Kathrin M., Neff, Tobias

“…Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional…”
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MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches by Winters, Amanda C., Bernt, Kathrin M.

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MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L by Bernt, Kathrin M., Zhu, Nan, Sinha, Amit U., Vempati, Sridhar, Faber, Joerg, Krivtsov, Andrei V., Feng, Zhaohui, Punt, Natalie, Daigle, Amanda, Bullinger, Lars, Pollock, Roy M., Richon, Victoria M., Kung, Andrew L., Armstrong, Scott A.

“…The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage…”
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Mapping human hematopoiesis by Bernt, Kathrin M.

“…Understanding normal hematopoiesis is critical to understanding disease. Technological advances are driving insight into human hematopoiesis at unprecedented…”
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Menin dependence: UBTF-ITD AML joins the club by Bernt, Kathrin M.

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Do you need the immune system to cure ALL? by Bernt, Kathrin M.

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DOT1L-Mediated H3K79 Methylation in Chromatin Is Dispensable for Wnt Pathway-Specific and Other Intestinal Epithelial Functions by Ho, Li-Lun, Sinha, Amit, Verzi, Michael, Bernt, Kathrin M., Armstrong, Scott A., Shivdasani, Ramesh A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia by Pingul, Bianca Y., Huang, Hua, Chen, Qingzhou, Alikarami, Fatemeh, Zhang, Zhen, Qi, Jun, Bernt, Kathrin M., Berger, Shelley L., Cao, Zhendong, Shi, Junwei

“…Transcriptional dysregulation is a prominent feature in leukemia. Here, we systematically surveyed transcription factor (TF) vulnerabilities in leukemia and…”
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The role of polycomb repressive complex 2 in early T-cell precursor acute lymphoblastic leukemia by Bernt, Kathrin M., Neff, Tobias

“…Genetic lesions affecting polycomb repressive complex 2 (PRC2) have been found in more than 40% of pediatric cases of early T-cell precursor acute…”
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MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches by Winters, Amanda C, Bernt, Kathrin M

“…The mixed-lineage leukemia 1 (MLL1) gene (now renamed or ) on chromosome 11q23 is disrupted in a unique group of acute leukemias. More than 80 different…”
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A Tumor-Targeted and Conditionally Replicating Oncolytic Adenovirus Vector Expressing TRAIL for Treatment of Liver Metastases by Sova, Pavel, Ren, Xiao-Wei, Ni, Shaoheng, Bernt, Kathrin M, Mi, Jie, Kiviat, Nancy, Lieber, André

“…We have constructed a new capsid-modified adenovirus (Ad) vector that specifically replicates in tumor cells and expresses TNF-related apoptosis-inducing…”
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