Search Results - "Bernstein‐Molho, Rinat"

Targeted genotyping for recurring variants in cancer susceptibility genes in non‐Ashkenazi Jewish patients with breast cancer diagnosed ≥50 years by Bernstein‐Molho, Rinat, Shhada, Narmeen Abu, Laitman, Yael, Netzer, Iris, Shoval, Shelley, Friedman, Eitan

“…Purpose Several recurring pathogenic variants (PVs) in BRCA1/BRCA2 and additional cancer susceptibility genes are described in the ethnically diverse Israeli…”
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Yield of targeted genotyping for the recurring pathogenic variants in cancer susceptibility genes in a healthy, multiethnic Israeli population by Bernstein‐Molho, Rinat, Galmor, Lee, Laitman, Yael, Segev, Shlomo, Friedman, Eitan

“…Background Several recurring pathogenic variants in BRCA1/BRCA2 and other cancer susceptibility genes are encountered in ethnically diverse Jewish populations…”
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The benefit of pancreatic cancer surveillance in carriers of germline BRCA1/2 pathogenic variants by Laish, Ido, Schechter, Menachem, Dancour, Alain, Lieberman, Sari, Levi, Zohar, Goldberg, Yael, Kedar, Inbal, Hasnis, Erez, Half, Elizabeth, Levi, Gili Reznick, Katz, Lior, Vainer, Elez D., Genzel, Dor, Aharoni, Maya, Chen‐Shtoyerman, Rakefet, Abu‐Freha, Naim, Raitses‐Gurevich, Maria, Golan, Talia, Bernstein‐Molho, Rinat, Ben Yehoyada, Merav, Gluck, Nathan, Rosner, Guy

“…Background Surveillance of high‐risk individuals for pancreatic ductal adenocarcinoma (PDAC) is recommended. This study aimed to determine the prevalence and…”
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The spectrum of BRCA1 and BRCA2 pathogenic sequence variants in Middle Eastern, North African, and South European countries by Laitman, Yael, Friebel, Tara M., Yannoukakos, Drakoulis, Fostira, Florentia, Konstantopoulou, Irene, Figlioli, Gisella, Bonanni, Bernardo, Manoukian, Siranoush, Zuradelli, Monica, Tondini, Carlo, Pasini, Barbara, Peterlongo, Paolo, Plaseska‐Karanfilska, Dijana, Jakimovska, Milena, Majidzadeh, Keivan, Zarinfam, Shiva, Loizidou, Maria A., Hadjisavvas, Andreas, Michailidou, Kyriaki, Kyriacou, Kyriacos, Behar, Doron M., Molho, Rinat Bernstein, Ganz, Patricia, James, Paul, Parsons, Michael T., Sallam, Aminah, Olopade, Olufunmilayo I., Seth, Arun, Chenevix ‐ Trench, Georgia, Leslie, Goska, McGuffog, Lesley, Marafie, Makia J, Megarbane, Andre, Al‐Mulla, Fahd, Rebbeck, Timothy R., Friedman, Eitan

“…BRCA1 BRCA2 mutational spectrum in the Middle East, North Africa, and Southern Europe is not well characterized. The unique history and cultural practices…”
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Uterine cancer in Jewish Israeli BRCA1/2 mutation carriers by Laitman, Yael, Michaelson‐Cohen, Rachel, Levi, Einat, Chen‐Shtoyerman, Rakefet, Reish, Orit, Josefsberg Ben‐Yehoshua, Sagi, Bernstein‐Molho, Rinat, Keinan‐Boker, Lital, Rosengarten, Ora, Silverman, Barbara G., Perri, Tamar, Korach, Jacob, Mor, Pnina, Ephrat Ben‐Baruch, Noa, Levy Lahad, Ephrat, Friedman, Eitan

“…Background BRCA1/2 mutation carriers have an increased risk of developing ovarian cancer, leading to the recommendation of risk‐reducing salpingo‐oophorectomy…”
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Re‐evaluating the pathogenicity of the c.783+2T>C BAP1 germline variant by Goldberg, Yael, Laitman, Yael, Ben David, Merav, Bazak, Lily, Lidzbarsky, Gabriel, Salmon, Lina B., Shkedi‐Rafid, Shiri, Barshack, Iris, Avivi, Camila, Darawshe, Malak, Shomron, Noam, Bruchim, Revital, Vinkler, Chana, Yannoukakos, Drakoulis, Fostira, Florentia, Bernstein‐Molho, Rinat, Friedman, Eitan

“…BAP1 germline pathogenic sequence variants (PSVs) underlie a unique tumor predisposition syndrome (BAP1‐TPDS) associated with an increased lifetime risk for…”
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Double heterozygosity for TP53 and BRCA1 mutations: clinical implications in populations with founder mutations by Shani, Hagit, Bernstein-Molho, Rinat, Laitman, Yael, Netzer, Iris, Friedman, Eitan

“…Purpose The co-occurrence or double heterozygosity of pathogenic/likely pathogenic sequence variants (P/LPSVs) in major cancer susceptibility genes has rarely…”
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Time trends in uptake rates of risk-reducing mastectomy in Israeli asymptomatic BRCA1 and BRCA2 mutation carriers by Galmor, Lee, Bernstein-Molho, Rinat, Sklair-Levy, Miri, Madoursky-Feldman, Dana, Zippel, Dov, Laitman, Yael, Friedman, Eitan

“…Background The rate of risk-reducing bilateral mastectomy (RRBM) among cancer-free Israeli female BRCA1/BRCA2 mutation carriers was reportedly 13% in 2010…”
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De novo pathogenic germline variant in PALB2 in a patient with pancreatic cancer by Bernstein Molho, Rinat, Zalmanoviz, Shelly, Laitman, Yael, Friedman, Eitan

“…De novo mutations in the major breast/ovarian cancer susceptibility genes BRCA1 and BRCA2 are rare. De novo mutations in the PALB2 gene have never been…”
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Breast cancer surveillance for BRCA1/2 mutation carriers – is “early detection” early enough? by Bernstein-Molho, Rinat, Kaufman, Bella, Ben David, Merav A., Sklair-Levy, Miri, Feldman, Dana Madoursky, Zippel, Dov, Laitman, Yael, Friedman, Eitan

“…Annual MRI screening is associated with a significant reduction in advanced-stage breast cancer diagnosis in BRCA1/2 mutation carriers. The impact that early…”
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Diagnostic yield of multigene panel testing in an Israeli cohort: enrichment of low-penetrance variants by Bernstein-Molho, Rinat, Friedman, Eitan, Kedar, Inbal, Laitman, Yael, Allweis, Tanir M., Gal-Yam, Einav Nili, Feldman, Hagit Baris, Grinshpun, Albert, Halpern, Naama, Hartmajer, Shulamit, Kadouri, Luna, Katz, Lior H., Kaufman, Bella, Laish, Ido, Levanon, Keren, Philipsborn, Shira Litz, Ludman, Mark, Moran, Gal, Peretz, Tamar, Reinstein, Eyal, Levi, Gili Reznick, Safra, Tamar, Shkedi, Shiri, Vinkler, Chana, Levy, Zohar, Goldberg, Yael

“…Background Carriers of pathogenic variants (PVs) in moderate–high-penetrance cancer susceptibility genes are offered tailored surveillance schemes for early…”
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The complexity of management of pregnancy-associated malignant soft tissue and bone tumors by Molho, Rinat Bernstein, Kollender, Yehuda, Issakov, Josephine, Bickels, Jacob, Flusser, Gideon, Azem, Fuad, Alon, Adele, Inbar, Moshe J, Meller, Isaac, Merimsky, Ofer

“…The incidence of musculoskeletal tumors during pregnancy is very low. The aim of this study was to summarize our experience in treating a large cohort of…”
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Age at diagnosis of cancer in 185delAG BRCA1 mutation carriers of diverse ethnicities: tentative evidence for modifier factors by Laitman, Yael, Michaelson-Cohen, Rachel, Chen-Shtoyerman, Rakefet, Goldberg, Yael, Reish, Orit, Bernstein-Molho, Rinat, Levy-Lahad, Ephrat, Baruch, Noa Ephrat Ben, Kedar, Inbal, Evans, D. Gareth, Haim, Sara, Paluch-Shimon, Shani, Friedman, Eitan

“…Germline pathogenic sequence variants (PSVs) in BRCA1 substantially increase risk for developing breast (BC) and ovarian cancer (OvC). Yet, incomplete…”
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Cranial irradiation in childhood mimicking neurofibromatosis type II by Bokstein, Felix, Dubov, Tom, Toledano‐Alhadef, Hagit, Bernstein‐Molho, Rinat, Constantini, Shlomi, Evans, D. Gareth, Ben‐Shachar, Shay

“…Neurofibromatosis type II (NF2) is a genetic disease characterized by bilateral vestibular schwannomas (VS) and other nerve system tumors. However, such tumors…”
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3345: Hereditary cancer syndromes and genetic susceptibility affecting radiation decisions by Bernstein-Molho, Rinat

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Combined weekly carboplatin and paclitaxel as primary treatment of advanced epithelial ovarian carcinoma by Safra, Tamar, Menczer, Joseph, Bernstein, Rinat Molho, Shpigel, Shulem, Matcejevsky, Dianna, Inbar, Moshe J, Golan, Abraham, Grisaru, Dan, Levy, Tally

“…Abstract Objective To evaluate safety and outcome of weekly carboplatin and paclitaxel as the initial postoperative adjuvant chemotherapy for epithelial…”
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Controversies and Open Questions in Management of Cancer-Free Carriers of Germline Pathogenic Variants in BRCA1/BRCA2 by Bernstein-Molho, Rinat, Friedman, Eitan, Evron, Ella

“…Females harboring germline BRCA1/BRCA2 (BRCA) P/LPV are offered a tight surveillance scheme from the age of 25−30 years, aimed at early detection of specific…”
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Controversies and Open Questions in Management of Cancer-Free Carriers of Germline Pathogenic Variants in IBRCA1/BRCA2/I by Bernstein-Molho, Rinat, Friedman, Eitan, Evron, Ella

“…Female carriers of germline pathogenic/likely pathogenic variants (P/LPVs) in the BRCA1/BRCA2 (BRCA) genes are at a substantially increased lifetime risk for…”
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Genetic testing in patients with triple-negative or hereditary breast cancer by Bernstein-Molho, Rinat, Evron, Ella, Yerushalmi, Rinat, Paluch-Shimon, Shani

“…PURPOSE OF REVIEWIn recent years there has been a dramatic evolution in the clinical utility of genetic testing with expanding therapeutic implications for…”
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Loss of Function RET Gene Variant and Cancer: Co-occurrence or an Association? by Laitman, Yael, Bernstein-Molho, Rinat, Golan, Talia, Friedman, Eitan

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