Search Results - "Berns, Eric J"

Aligned neurite outgrowth and directed cell migration in self-assembled monodomain gels by Berns, Eric J, Sur, Shantanu, Pan, Liuliu, Goldberger, Joshua E, Suresh, Sunitha, Zhang, Shuming, Kessler, John A, Stupp, Samuel I

“…Abstract Regeneration of neural tissues will require regrowth of axons lost due to trauma or degeneration to reestablish neuronal connectivity. One approach…”
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Surface potential modulation as a tool for mitigating challenges in SERS-based microneedle sensors by Brasiliense, Vitor, Park, Ji Eun, Berns, Eric J., Van Duyne, Richard P., Mrksich, Milan

“…Raman spectroscopic-based biosensing strategies are often complicated by low signal and the presence of multiple chemical species. While surface-enhanced Raman…”
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A tenascin-C mimetic peptide amphiphile nanofiber gel promotes neurite outgrowth and cell migration of neurosphere-derived cells by Berns, Eric J., Álvarez, Zaida, Goldberger, Joshua E., Boekhoven, Job, Kessler, John A., Kuhn, H. Georg, Stupp, Samuel I.

“…[Display omitted] Biomimetic materials that display natural bioactive signals derived from extracellular matrix molecules like laminin and fibronectin hold…”
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Temporal Sampling of Enzymes from Live Cells by Localized Electroporation and Quantification of Activity by SAMDI Mass Spectrometry by Mukherjee, Prithvijit, Berns, Eric J., Patino, Cesar A., Hakim Moully, Elamar, Chang, Lingqian, Nathamgari, S. Shiva P., Kessler, John A., Mrksich, Milan, Espinosa, Horacio D.

“…Measuring changes in enzymatic activity over time from small numbers of cells remains a significant technical challenge. In this work, a method for sampling…”
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Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles by Matsuoka, Akihiro J, Sayed, Zafar A, Stephanopoulos, Nicholas, Berns, Eric J, Wadhwani, Anil R, Morrissey, Zachery D, Chadly, Duncan M, Kobayashi, Shun, Edelbrock, Alexandra N, Mashimo, Tomoji, Miller, Charles A, McGuire, Tammy L, Stupp, Samuel I, Kessler, John A

“…The use of human embryonic stem cells (hESCs) for regeneration of the spiral ganglion will require techniques for promoting otic neuronal progenitor (ONP)…”
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Supramolecular Nanofibers of Peptide Amphiphiles for Medicine by Webber, Matthew J., Berns, Eric J., Stupp, Samuel I.

“…Peptide nanostructures are an exciting class of supramolecular systems that can be designed for novel therapies with great potential in advanced medicine. This…”
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β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells by Pan, Liuliu, North, Hilary A, Sahni, Vibhu, Jeong, Su Ji, Mcguire, Tammy L, Berns, Eric J, Stupp, Samuel I, Kessler, John A

“…Astrogliosis with glial scar formation after damage to the nervous system is a major impediment to axonal regeneration and functional recovery. The present…”
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High-Throughput Microfluidics Platform for Intracellular Delivery and Sampling of Biomolecules from Live Cells by Patino, Cesar A., Mukherjee, Prithvijit, Berns, Eric J., Moully, Elamar Hakim, Stan, Liliana, Mrksich, Milan, Espinosa, Horacio D.

“…Nondestructive cell membrane permeabilization systems enable the intracellular delivery of exogenous biomolecules for cell engineering tasks as well as the…”
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Traceless Immobilization of Analytes for High-Throughput Experiments with SAMDI Mass Spectrometry by Helal, Kazi Y, Alamgir, Azmain, Berns, Eric J, Mrksich, Milan

“…Label-free assays, and particularly those based on the combination of mass spectroscopy with surface chemistries, enable high-throughput experiments of a broad…”
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Synthesis and Activity of T‑Cell Tumor-Directing MegaMolecules by Sridhar, Sraeyes, Modica, Justin A., Sykora, Daniel J., Berns, Eric J., Mrksich, Milan

“…This paper describes the synthesis, characterization, and functional activity of 26 MegaMolecule-based bispecific antibody mimics for T-cell redirection toward…”
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Exploration of the nanomedicine-design space with high-throughput screening and machine learning by Yamankurt, Gokay, Berns, Eric J., Xue, Albert, Lee, Andrew, Bagheri, Neda, Mrksich, Milan, Mirkin, Chad A.

“…Only a tiny fraction of the nanomedicine-design space has been explored, owing to the structural complexity of nanomedicines and the lack of relevant…”
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Label-Free Assay of Protein Tyrosine Phosphatase Activity in Single Cells by Moully, Elamar Hakim, Berns, Eric J, Mrksich, Milan

“…Populations of cells exhibit variations in biochemical activity, resulting from many factors including random stochastic variability in protein production,…”
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A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers by Li, Andrew, Hokugo, Akishige, Yalom, Anisa, Berns, Eric J, Stephanopoulos, Nicholas, McClendon, Mark T, Segovia, Luis A, Spigelman, Igor, Stupp, Samuel I, Jarrahy, Reza

“…Abstract Peripheral nerve injuries can result in lifelong disability. Primary coaptation is the treatment of choice when the gap between transected nerve ends…”
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Cellular Assays with a Molecular Endpoint Measured by SAMDI Mass Spectrometry by Berns, Eric J., Cabezas, Maria D., Mrksich, Milan

“…Cell‐based, high‐throughput screening (HTS) assays are increasingly important tools used in drug discovery, but frequently rely on readouts of gene expression…”
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HaloTag-Modified, Ferrocene Labeled Self-Assembled Monolayers for Protein Sensing by Brotherton, Andrew R., Neupane, Guru P., Ji, Xudong, Sullivan, Kyle, Bailey, Matthew D., Berns, Eric J., Rivnay, Jonathan, Mrksich, Milan, Meade, Thomas J.

“…Ferrocene (Fc)-based disulfide molecules of various lengths with amino acid scaffolds and alkane or oligo­(phenylene-ethynylene) (OPE) bridges are used in a…”
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Combining SAMDI Mass Spectrometry and Peptide Arrays to Profile Phosphatase Activities by Szymczak, Lindsey C, Huang, Che-Fan, Berns, Eric J, Mrksich, Milan

“…Phosphatases, the enzymes responsible for dephosphorylating proteins, play critical roles in many cellular processes. While their importance is widely…”
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Electrostatic Control of Bioactivity by Goldberger, Joshua E., Berns, Eric J., Bitton, Ronit, Newcomb, Christina J., Stupp, Samuel I.

“…The power of independence: When exhibited on the surface of self‐assembling peptide‐amphiphile nanofibers, the hydrophobic laminin‐derived IKVAV epitope…”
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Measuring Drug Metabolism Kinetics and Drug–Drug Interactions Using Self-Assembled Monolayers for Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry by Anderson, Lyndsey L, Berns, Eric J, Bugga, Pradeep, George, Alfred L, Mrksich, Milan

“…The competition of two drugs for the same metabolizing enzyme is a common mechanism for drug–drug interactions that can lead to altered kinetics in drug…”
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In vivo migration of endogenous brain progenitor cells guided by an injectable peptide amphiphile biomaterial by Motalleb, Reza, Berns, Eric J., Patel, Piyush, Gold, Julie, Stupp, Samuel I., Kuhn, H. Georg

“…Biomaterials hold great promise in helping the adult brain regenerate and rebuild after trauma. Peptide amphiphiles (PAs) are highly versatile biomaterials,…”
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Cell-Based Screening: Cellular Assays with a Molecular Endpoint Measured by SAMDI Mass Spectrometry (Small 28/2016) by Berns, Eric J., Cabezas, Maria D., Mrksich, Milan

“…On page 3811, M. Mrksich and co‐workers culture cells using self‐assembled monolayers presenting cell adhesion ligands and enzyme substrates. A lysis buffer…”
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