Search Results - "Bernoulli, Jenni"

Insights into immuno-oncology drug development landscape with focus on bone metastasis by Kähkönen, Tiina E, Halleen, Jussi M, MacRitchie, Gary, Andersson, Ronnie M, Bernoulli, Jenni

“…Bone is among the main sites of metastasis in breast, prostate and other major cancers. Bone metastases remain incurable causing high mortality, severe…”
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The Translational Role of Animal Models for Estrogen-Related Functional Bladder Outlet Obstruction and Prostatic Inflammation by Santti, Risto, Yatkin, Emrah, Bernoulli, Jenni, Streng, Tomi

“…The prevalence of LUTS and prostatic diseases increases with age both in humans and companion animals, suggesting that a common underlying cause of these…”
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Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis by Kähkönen, Tiina E, Halleen, Jussi M, Bernoulli, Jenni

“…Immunotherapies provide a potential treatment option for currently incurable bone metastases. Bone marrow is an important secondary lymphoid organ with a…”
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Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone by Bernoulli, Jenni, Tanaka, Azusa, Halleen, Jussi M., Mäki-Jouppila, Jenni H. E., Suominen, Mari I., Kähkönen, Tiina E., Seiler, Michael

“…Bone metastases are prevalent in many common cancers such as breast, prostate, and lung cancers, and novel therapies for treating bone metastases are needed…”
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Fispemifene [Z-2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)-phenoxy]ethoxy}-ethanol], a novel selective estrogen receptor modulator, attenuates glandular inflammation in an animal model of chronic nonbacterial prostatitis by Yatkin, Emrah, Bernoulli, Jenni, Lammintausta, Risto, Santti, Risto

“…The anti-inflammatory and antiestrogenic action of fispemifene [Z-2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}-ethanol], a novel selective estrogen…”
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Urodynamic changes in a noble rat model for nonbacterial prostatic inflammation by Bernoulli, Jenni, Yatkin, Emrah, Talvitie, Eva-Maria, Santti, Risto, Streng, Tomi

“…BACKGROUND Chronic nonbacterial prostatitis (CP) associated with voiding dysfunction is a poorly understood clinical phenomenon. The goal of the present study…”
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Abstract 2870: Limited data from clinical trials assessing immunotherapy effects on bone metastases by Kähkönen, Tiina E., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Bone metastases are a significant cause of mortality in many major cancers. They are difficult to treat and their response rate to standard-of-care…”
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Chronic nonbacterial prostate inflammation in a rat model is associated with changes of gut microbiota that can be modified with a galactoglucomannan‐rich hemicellulose extract in the diet by Konkol, Yvonne, Keskitalo, Anniina, Vuorikoski, Heikki, Pietilä, Sami, Elo, Laura L., Munukka, Eveliina, Bernoulli, Jenni, Tuomela, Johanna

“…Objectives To investigate dietary effects on the gut microbiota composition in a rat model of nonbacterial chronic prostate inflammation (CPI). Materials and…”
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Abstract 5026: Efficacy of anti-PD-1, IDO inhibitor, chemotherapy and bone-targeting agent on tumor growth in a syngeneic bone metastasis model of triple-negative breast cancer by Kähkönen, Tiina Emilia, Suominen, Mari I., Mäki-Jouppila, Jenni H., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Triple-negative breast cancer (TNBC) is an aggressive cancer with treatment options limited to standard-of-care chemotherapy. TNBC patients develop…”
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Abstract 4616: Establishment of a metastatic orthotopic model of pancreatic ductal adenocarcinoma (PDAC) for drug development by Zdrojewska, Justyna, Mäki-Jouppila, Jenni H.E., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Ductal adenocarcinoma of the pancreas (PDAC) has the worst survival prognosis (<5%) of all common gastrointestinal malignancies. PDAC is typically…”
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Abstract 4850: The relevance of using proper preclinical models when developing therapeutics for localized or bone metastatic prostate cancer by Kähkönen, Tiina E., Mäki-Jouppila, Jenni H.E., Suominen, Mari I., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Early stages of prostate cancer are sensitive to androgen deprivation therapy, but upon progression the disease develops to metastatic…”
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Abstract 4588: Characterization of anti-CTLA-4 effects on tumor growth and immune microenvironment in a syngeneic CT26.WT colon carcinoma mouse model by Mäki-Jouppila, Jenni H., Kähkönen, Tiina E., Suominen, Mari I., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Colorectal cancer is the third most common type of cancer and one of the leading causes of cancer related deaths. It is a group of various diseases at…”
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Abstract 2007: Validation of a preclinical model for bone metastatic triple negative breast cancer by Zdrojewska, Justyna, Suominen, Mari I., Fagerlund, Katja M., Halleen, Jussi M., Bernoulli, Jenni, Zimmermann, Johann

“…Abstract Metastatic breast cancer (MBC) is the most advanced stage of breast cancer, diagnosed as stage IV. Typically, MBC metastases occur in the bones,…”
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Galactoglucomannan-rich hemicellulose extract from Norway spruce (Picea abies) exerts beneficial effects on chronic prostatic inflammation and lower urinary tract symptoms in vivo by Konkol, Yvonne, Vuorikoski, Heikki, Tuomela, Johanna, Holmbom, Bjarne, Bernoulli, Jenni

“…Galactoglucomannan (GGM) is the main hemicellulose class in wood of coniferous trees and could be potentially utilized as a possible health-promoting substance…”
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Abstract 1634: Orthotopic and bone metastasis prostate cancer models using the 22Rv1 cell line by Zdrojewska, Justyna, Kähkönen, Tiina E., Mäki-Jouppila, Jenni H., Valkonen, Masi, Ruusuvuori, Pekka, Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Prostate cancer is the most common cancer in men. Upon diagnosed malignancy the growth of the tumors is androgen driven in a majority of the cases…”
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Abstract 5740: Identification of genetic signatures in bone metastasis of breast and prostate cancer by Kähkönen, Tiina E., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Bone metastases (BM) cause high mortality and are present in 70-90% of advanced breast and prostate cancer patients. Cancer is a complex genetic…”
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Abstract 709: Anti-PD-1 therapy reduces bone lesion growth in a novel syngeneic bladder cancer bone metastasis model by Kähkönen, Tiina E., Suominen, Mari I., Halleen, Jussi M., Bernoulli, Jenni, Scholz, Arne

“…Abstract Bladder cancer is a common and aggressive type of cancer occurring both in women and in men. At diagnosis, lymph node involvement is frequently…”
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Abstract 1162: Castration-resistant prostate cancer bone metastasis model to assess new therapeutics by Kähkönen, Tiina E., Suominen, Mari I., Halleen, Jussi M., Bernoulli, Jenni, Lejeune, Pascale

“…Abstract The role of androgens in the regulation of growth of primary prostate cancer is well established but less recognized in the context of advanced bone…”
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Abstract 4614: Establishment of a HER2 positive breast cancer bone metastasis model for validation of novel therapies by Kähkönen, Tiina E., Suominen, Mari I., Mäki-Jouppila, Jenni H., Halleen, Jussi M., Bernoulli, Jenni, Grant, Derek

“…Abstract Breast cancers with overexpression of human epidermal growth factor receptor 2 (HER2+) have aggressive clinical behavior, and at advanced stages are…”
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Abstract 2814: Systemic and local bone metastasis models for immuno-oncology drug development by Kähkönen, Tiina E., Suominen, Mari I., Mäki-Jouppila, Jenni H., Halleen, Jussi M., Scholz, Arne, Bernoulli, Jenni

“…Abstract Bone metastases are common and count 30-70% of metastases in breast, lung, and bladder cancer, and 80% of multiple myeloma patients have bone disease…”
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