Search Results - "Bernier, Sylvie"

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH by Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.

“…Endothelial dysfunction and reduced nitric oxide (NO) signaling are a key element of the pathophysiology of nonalcoholic steatohepatitis (NASH). Stimulators of…”
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Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase by Wales, Jessica A., Chen, Cheng-Yu, Breci, Linda, Weichsel, Andrzej, Bernier, Sylvie G., Sheppeck, James E., Solinga, Robert, Nakai, Takashi, Renhowe, Paul A., Jung, Joon, Montfort, William R.

“…Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a highly sought-after therapeutic target for the management of cardiovascular diseases. New…”
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Rapid discovery and evolution of nanosensors containing fluorogenic amino acids by Kuru, Erkin, Rittichier, Jonathan, de Puig, Helena, Flores, Allison, Rout, Subhrajit, Han, Isaac, Reese, Abigail E., Bartlett, Thomas M., De Moliner, Fabio, Bernier, Sylvie G., Galpin, Jason D., Marchand, Jorge, Bedell, William, Robinson-McCarthy, Lindsey, Ahern, Christopher A., Bernhardt, Thomas G., Rudner, David Z., Collins, James J., Vendrell, Marc, Church, George M.

“…Binding-activated optical sensors are powerful tools for imaging, diagnostics, and biomolecular sensing. However, biosensor discovery is slow and requires…”
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The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system by Correia, Susana S, Liu, Guang, Jacobson, Sarah, Bernier, Sylvie G, Tobin, Jenny V, Schwartzkopf, Chad D, Atwater, Emily, Lonie, Elisabeth, Rivers, Sam, Carvalho, Andrew, Germano, Peter, Tang, Kim, Iyengar, Rajesh R, Currie, Mark G, Hadcock, John R, Winrow, Christopher J, Jones, Juli E

“…Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine…”
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Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease by Tchernychev, Boris, Li, Huihui, Lee, Sung‐Kyun, Gao, Xin, Ramanarasimhaiah, Raghunath, Liu, Guang, Hall, Katherine C., Bernier, Sylvie G., Jones, Juli E., Feil, Susanne, Feil, Robert, Buys, Emmanuel S., Graul, Regina M., Frenette, Paul S., Masferrer, Jaime L.

“…Background and Purpose Reduced bioavailability of NO, a hallmark of sickle cell disease (SCD), contributes to intravascular inflammation, vasoconstriction,…”
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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease by Tobin, Jenny V, Zimmer, Daniel P, Shea, Courtney, Germano, Peter, Bernier, Sylvie G, Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, 2nd, James, Moore, Joel D, Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R, Profy, Albert T, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L

“…Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5'-triphosphate to cGMP upon binding of nitric oxide…”
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The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases by Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.

“…Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging…”
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The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes by Ge, Pei, Navarro, Iris D, Kessler, Marco M, Bernier, Sylvie G, Perl, Nicholas R, Sarno, Renee, Masferrer, Jaime, Hannig, Gerhard, Stamer, W Daniel

“…The nitric oxide (NO)-cyclic guanosine-3',5'-monophosphate (cGMP) pathway regulates aqueous humor outflow and therefore, intraocular pressure. We investigated…”
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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease by Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L

“…Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth…”
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Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator by Rennie, Glen R., Barden, Timothy C., Bernier, Sylvie G., Carvalho, Andrew, Deming, Renee, Germano, Peter, Hudson, Colleen, Im, G-Yoon J., Iyengar, Rajesh R., Jia, Lei, Jung, Joon, Kim, Elise, Lee, Thomas W.-H., Mermerian, Ara, Moore, Joel, Nakai, Takashi, Perl, Nicholas R., Tobin, Jenny, Zimmer, Daniel P., Renhowe, Paul A.

“…[Display omitted] Soluble guanylate cyclase (sGC) is a clinically validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC…”
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Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo by Ranganath, Sheila, Bhandari, Ashok, Avitahl-Curtis, Nicole, McMahon, Jaimee, Wachtel, Derek, Zhang, Jenny, Leitheiser, Christopher, Bernier, Sylvie G, Liu, Guang, Tran, Tran T, Celino, Herodion, Tobin, Jenny, Jung, Joon, Zhao, Hong, Glen, Katie E, Graul, Chris, Griffin, Aliesha, Schairer, Wayne C, Higgins, Carolyn, Reza, Tammi L, Mowe, Eva, Rivers, Sam, Scott, Sonya, Monreal, Alex, Shea, Courtney, Bourne, Greg, Coons, Casey, Smith, Adaline, Tang, Kim, Mandyam, Ramya A, Masferrer, Jaime, Liu, David, Patel, Dinesh V, Fretzen, Angelika, Murphy, Craig A, Milne, G Todd, Smythe, Mark L, Carlson, Kenneth E

“…Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6…”
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Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis by Deng, Hongfeng, Bernier, Sylvie G, Doyle, Elisabeth, Lorusso, Jeanine, Morgan, Barry A, Westlin, William F, Evindar, Ghotas

“…To develop effective oral treatment for multiple sclerosis (MS), we discovered a series of alkyl-substituted biaryl amino alcohols as selective S1P1…”
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A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis by Bernier, Sylvie G., Lazarus, Douglas D., Clark, Edward, Doyle, Beth, Labenski, Matthew T., Thompson, Charles D., Westlin, William F., Hannig, Gerhard, Erikson, R. L.

“…The hallmark of rheumatoid arthritis (RA) is the progressive destruction of articular joints, characterized by invasive synovial hyperplasia and pathological…”
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Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1 by Gobeil, Fernand, Bernier, Sylvie G., Vazquez-Tello, Alejandro, Brault, Sonia, Beauchamp, Martin H., Quiniou, Christiane, Marrache, Anne Marilise, Checchin, Daniella, Sennlaub, Florian, Hou, Xin, Nader, Mony, Bkaily, Ghassan, Ribeiro-da-Silva, Alfredo, Goetzl, Edward J., Chemtob, Sylvain

“…Lysophosphatidic acid (LPA) is a bioactive molecule involved in inflammation, immunity, wound healing, and neoplasia. Its pleiotropic actions arise presumably…”
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Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1 by Evindar, Ghotas, Deng, Hongfeng, Bernier, Sylvie G, Doyle, Elisabeth, Lorusso, Jeanine, Morgan, Barry A, Westlin, William F

“…In the quest to discover a potent and selective class of direct agonists to the sphingosine-1-phosphate receptor, we explored the carboxylate functional group…”
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Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation by Silos-Santiago, Inmaculada, Hannig, Gerhard, Eutamene, Helene, Ustinova, Elena E., Bernier, Sylvie G., Ge, Pei, Graul, Christopher, Jacobson, Sarah, Jin, Hong, Liong, Elaine, Kessler, Marco M., Reza, Tammi, Rivers, Samuel, Shea, Courtney, Tchernychev, Boris, Bryant, Alexander P., Kurtz, Caroline B., Bueno, Lionel, Pezzone, Michael A., Currie, Mark G.

“…Uroguanylin activation of the guanylate cyclase-C/cyclic guanosine monophosphate pathway elicits analgesic effects in animal models of colonic…”
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Methionine aminopeptidases type I and type II are essential to control cell proliferation by Bernier, Sylvie G., Taghizadeh, Nazbeh, Thompson, Charles D., Westlin, William F., Hannig, Gerhard

“…The dependence of cell growth on methionine aminopeptidase (MetAP) function in bacteria and yeast is firmly established. Here we report experimental evidence…”
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Regulation of eNOS Expression in Brain Endothelial Cells by Perinuclear EP3 Receptors by Gobeil, Fernand, Dumont, Isabelle, Marrache, Anne Marilise, Vazquez-Tello, Alejandro, Bernier, Sylvie G, Abran, Daniel, Hou, Xin, Beauchamp, Martin H, Quiniou, Christiane, Bouayad, Asmaa, Choufani, Sanaa, Bhattacharya, Mousumi, Molotchnikoff, Stephane, Ribeiro-da-Silva, Alfredo, Varma, Daya R, Bkaily, Ghassan, Chemtob, Sylvain

“…We reported upregulation of endothelial nitric oxide synthase (eNOS) by PGE2 in tissues and presence of perinuclear PGE2 receptors (EP). We presently studied…”
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Proinflammatory Gene Induction by Platelet-Activating Factor Mediated Via Its Cognate Nuclear Receptor by Marrache, A. Marilise, Gobeil, Fernand, Jr, Bernier, Sylvie G, Stankova, Jana, Rola-Pleszczynski, Marek, Choufani, Sanaa, Bkaily, Ghassan, Bourdeau, Annie, Sirois, Martin G, Vazquez-Tello, Alejandro, Fan, Li, Joyal, Jean-Sebastien, Filep, Janos G, Varma, Daya R, Ribeiro-da-Silva, Alfredo, Chemtob, Sylvain

“…It has been postulated that intracellular binding sites for platelet-activating factor (PAF) contribute to proinflammatory responses to PAF. Isolated nuclei…”
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Altered vascular function in fetal programming of hypertension by LAMIREAU, Delphine, NUYT, Anne Monique, XIN HOU, BERNIER, Sylvie, BEAUCHAMP, Martin, GOBEIL, Fernand JR, LAHAIE, Isabelle, VARMA, Daya R, CHEMTOB, Sylvain

“…Reduced endothelium-dependent vasorelaxation partly due to loss of nitric oxide (NO) bioavailability occurs in most cases of chronic hypertension. Intrauterine…”
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