Search Results - "Bernier, G."

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH by Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.

“…Endothelial dysfunction and reduced nitric oxide (NO) signaling are a key element of the pathophysiology of nonalcoholic steatohepatitis (NASH). Stimulators of…”
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Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase by Wales, Jessica A., Chen, Cheng-Yu, Breci, Linda, Weichsel, Andrzej, Bernier, Sylvie G., Sheppeck, James E., Solinga, Robert, Nakai, Takashi, Renhowe, Paul A., Jung, Joon, Montfort, William R.

“…Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a highly sought-after therapeutic target for the management of cardiovascular diseases. New…”
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Rapid discovery and evolution of nanosensors containing fluorogenic amino acids by Kuru, Erkin, Rittichier, Jonathan, de Puig, Helena, Flores, Allison, Rout, Subhrajit, Han, Isaac, Reese, Abigail E., Bartlett, Thomas M., De Moliner, Fabio, Bernier, Sylvie G., Galpin, Jason D., Marchand, Jorge, Bedell, William, Robinson-McCarthy, Lindsey, Ahern, Christopher A., Bernhardt, Thomas G., Rudner, David Z., Collins, James J., Vendrell, Marc, Church, George M.

“…Binding-activated optical sensors are powerful tools for imaging, diagnostics, and biomolecular sensing. However, biosensor discovery is slow and requires…”
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The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system by Correia, Susana S, Liu, Guang, Jacobson, Sarah, Bernier, Sylvie G, Tobin, Jenny V, Schwartzkopf, Chad D, Atwater, Emily, Lonie, Elisabeth, Rivers, Sam, Carvalho, Andrew, Germano, Peter, Tang, Kim, Iyengar, Rajesh R, Currie, Mark G, Hadcock, John R, Winrow, Christopher J, Jones, Juli E

“…Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine…”
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Eating disorders in people with Type 1 diabetes: experiential perspectives of both clients and healthcare professionals by Macdonald, P., Kan, C., Stadler, M., De Bernier, G. L., Hadjimichalis, A., Le Coguic, A.‐S., Allan, J., Ismail, K., Treasure, J.

“…Aims To explore the experiential perspective of people with Type 1 diabetes mellitus and eating disorders and that of the healthcare professionals treating…”
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The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases by Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.

“…Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging…”
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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease by Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L

“…Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth…”
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GC-MS analysis of cuticular lipids in recent and older scavenger insect puparia. An approach to estimate the postmortem interval (PMI) by Frere, B., Suchaud, F., Bernier, G., Cottin, F., Vincent, B., Dourel, L., Lelong, A., Arpino, P.

“…An analytical method was developed to characterize puparia cuticular lipids (hydrocarbons, waxes) and to compare the molecular distribution patterns in the…”
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Bradykinin-regulated Interactions of the Mitogen-activated Protein Kinase Pathway with the Endothelial Nitric-oxide Synthase by Bernier, Sylvie G., Haldar, Saptarsi, Michel, Thomas

“…Activation of the bradykinin B2 receptor in endothelial cells initiates a complex array of cellular responses mediated by diverse signaling pathways, including…”
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Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1 by Gobeil, Fernand, Bernier, Sylvie G., Vazquez-Tello, Alejandro, Brault, Sonia, Beauchamp, Martin H., Quiniou, Christiane, Marrache, Anne Marilise, Checchin, Daniella, Sennlaub, Florian, Hou, Xin, Nader, Mony, Bkaily, Ghassan, Ribeiro-da-Silva, Alfredo, Goetzl, Edward J., Chemtob, Sylvain

“…Lysophosphatidic acid (LPA) is a bioactive molecule involved in inflammation, immunity, wound healing, and neoplasia. Its pleiotropic actions arise presumably…”
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Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6 by Schwarz, M, Cecconi, F, Bernier, G, Andrejewski, N, Kammandel, B, Wagner, M, Gruss, P

“…We have studied the molecular basis of the Pax2 and Pax6 function in the establishment of visual system territories. Loss-of-function mutants have revealed…”
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Development of a new solvent extraction process based on butyl-1-[N,N-bis(2-ethylhexyl)carbamoyl]nonyl phosphonic acid for the selective recovery of uranium(VI) from phosphoric acid by Miguirditchian, M., Bernier, G., Pacary, V., Balaguer, C., Sorel, C., Berlemont, R., Fries, B., Bertrand, M., Camès, B., Leydier, A., Turgis, R., Arrachart, G., Pellet-Rostaing, S., Mokhtari, H.

“…The promising new extractant molecule butyl-1-[N,N-bis(2-ethylhexyl)carbamoyl]nonyl phosphonic acid (DEHCNPB) was designed and used to develop a new solvent…”
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A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis by Bernier, Sylvie G., Lazarus, Douglas D., Clark, Edward, Doyle, Beth, Labenski, Matthew T., Thompson, Charles D., Westlin, William F., Hannig, Gerhard, Erikson, R. L.

“…The hallmark of rheumatoid arthritis (RA) is the progressive destruction of articular joints, characterized by invasive synovial hyperplasia and pathological…”
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Proinflammatory Gene Induction by Platelet-Activating Factor Mediated Via Its Cognate Nuclear Receptor by Marrache, A. Marilise, Gobeil, Fernand, Jr, Bernier, Sylvie G, Stankova, Jana, Rola-Pleszczynski, Marek, Choufani, Sanaa, Bkaily, Ghassan, Bourdeau, Annie, Sirois, Martin G, Vazquez-Tello, Alejandro, Fan, Li, Joyal, Jean-Sebastien, Filep, Janos G, Varma, Daya R, Ribeiro-da-Silva, Alfredo, Chemtob, Sylvain

“…It has been postulated that intracellular binding sites for platelet-activating factor (PAF) contribute to proinflammatory responses to PAF. Isolated nuclei…”
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Physiological signals that induce flowering by Bernier, G, Havelange, A, Houssa, C, Petitjean, A, Lejeune, P

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Prostanoid receptors: ontogeny and implications in vascular physiology by Wright, D H, Abran, D, Bhattacharya, M, Hou, X, Bernier, S G, Bouayad, A, Fouron, J C, Vazquez-Tello, A, Beauchamp, M H, Clyman, R I, Peri, K, Varma, D R, Chemtob, S

“…Prostanoids exert significant effects on circulatory beds. They play a role in the response of the vasculature to adjustments in perfusion pressure and oxygen…”
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Methionine aminopeptidases type I and type II are essential to control cell proliferation by Bernier, Sylvie G., Taghizadeh, Nazbeh, Thompson, Charles D., Westlin, William F., Hannig, Gerhard

“…The dependence of cell growth on methionine aminopeptidase (MetAP) function in bacteria and yeast is firmly established. Here we report experimental evidence…”
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Mechanical properties of reactive powder concretes by Dugat, J., Roux, N., Bernier, G.

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Use of the Allan deviation and linear prediction for the determination of the uncertainty on time calibrations against predicted timescales by Bernier, L.-G.

“…In this paper, two linear prediction algorithms and the Allan deviation are used to determine the uncertainty on time calibrations performed against predicted…”
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Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease by Tchernychev, Boris, Li, Huihui, Lee, Sung‐Kyun, Gao, Xin, Ramanarasimhaiah, Raghunath, Liu, Guang, Hall, Katherine C., Bernier, Sylvie G., Jones, Juli E., Feil, Susanne, Feil, Robert, Buys, Emmanuel S., Graul, Regina M., Frenette, Paul S., Masferrer, Jaime L.

“…Background and Purpose Reduced bioavailability of NO, a hallmark of sickle cell disease (SCD), contributes to intravascular inflammation, vasoconstriction,…”
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