Search Results - "Bernhagen, Jürgen"

Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets- An Updated View by Schulte, Wibke, Bucala, Richard, Bernhagen, Jürgen

“…Sepsis and septic shock are among the leading causes of death in intensive care units worldwide. Numerous studies on their pathophysiology have revealed an…”
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Macrophage Migration Inhibitory Factor in Cardiovascular Disease by ZERNECKE, Alma, BERNHAGEN, Jürgen, WEBER, Christian

“…The highly conserved and archetypical yet atypical cytokine macrophage migration inhibitory factor (MIF) fulfills pleiotropic immune functions in many acute…”
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A new cytokine target for chronic obstructive pulmonary disease? by Bernhagen, Jürgen

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D‐dopachrome tautomerase in cardiovascular and inflammatory diseases—A new kid on the block or just another MIF? by Zan, Chunfang, Yang, Bishan, Brandhofer, Markus, El Bounkari, Omar, Bernhagen, Jürgen

“…Macrophage migration inhibitory factor (MIF) as well as its more recently described structural homolog D‐dopachrome tautomerase (D‐DT), now also termed MIF‐2,…”
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Pharmacological Targeting of the CCL2/CCR2 Axis for Atheroprotection: A Meta-Analysis of Preclinical Studies by Živković, Luka, Asare, Yaw, Bernhagen, Jürgen, Dichgans, Martin, Georgakis, Marios K.

“…The CCL2 (CC-chemokine ligand 2)/CCR2 (CC-chemokine receptor 2) axis governs monocyte recruitment to atherosclerotic lesions. Genetic and epidemiological…”
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The Macrophage Migration Inhibitory Factor-Glucocorticoid Dyad: Regulation of Inflammation and Immunity by Flaster, Harry, Bernhagen, Jürgen, Calandra, Thierry, Bucala, Richard

“…The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive…”
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Lasso-grafted designer cytokines by Kapurniotu, Aphrodite, Bernhagen, Jürgen

“…Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood–brain barrier by genetically…”
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Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells by Schindler, Lisa, Zwissler, Leon, Krammer, Christine, Hendgen‐Cotta, Ulrike, Rassaf, Tienush, Hampton, Mark B., Dickerhof, Nina, Bernhagen, Jürgen

“…The chemokine‐like inflammatory cytokine macrophage migration inhibitory factor (MIF) is a pivotal driver of acute and chronic inflammatory conditions,…”
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The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model by Tian, Yuan, Milic, Jelena, Monasor, Laura Sebastián, Chakraborty, Rahul, Wang, Sijia, Yuan, Yue, Asare, Yaw, Behrends, Christian, Tahirovic, Sabina, Bernhagen, Jürgen

“…The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) is a deNEDDylase controlling ubiquitination activity of cullin-RING-E3 ligases (CRLs) and thus…”
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Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives by Pawig, Lukas, Klasen, Christina, Weber, Christian, Bernhagen, Jürgen, Noels, Heidi

“…CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow and their recruitment to sites of injury, as well as affect processes…”
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The Multitasking Potential of Alarmins and Atypical Chemokines by Kapurniotu, Aphrodite, Gokce, Ozgun, Bernhagen, Jürgen

“…When the human genome was sequenced, it came as a surprise that it contains "only" 21,306 protein-coding genes. However, complexity and diversity are…”
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MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model by Tilstam, Pathricia Veronica, Schulte, Wibke, Holowka, Thomas, Kim, Bong-Sung, Nouws, Jessica, Sauler, Maor, Piecychna, Marta, Pantouris, Georgios, Lolis, Elias, Leng, Lin, Bernhagen, Jürgen, Fingerle-Rowson, Günter, Bucala, Richard

“…Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter…”
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Impaired Macrophage Migration Inhibitory Factor-AMP-Activated Protein Kinase Activation and Ischemic Recovery in the Senescent Heart by HENG MA, JINGYING WANG, BUCALA, Richard, JI LI, THOMAS, D. Paul, CHAO TONG, LIN LENG, WENKUI WANG, MERK, Melanie, ZIEROW, Swen, BERNHAGEN, Jürgen, JUN REN

“…Elderly patients are more sensitive than younger patients to myocardial ischemia, which results in higher mortality. We investigated how aging affects the…”
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Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection by Baeza Garcia, Alvaro, Siu, Edwin, Sun, Tiffany, Exler, Valerie, Brito, Luis, Hekele, Armin, Otten, Gib, Augustijn, Kevin, Janse, Chris J., Ulmer, Jeffrey B., Bernhagen, Jürgen, Fikrig, Erol, Geall, Andrew, Bucala, Richard

“…Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria…”
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Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting by Kontos, Christos, El Bounkari, Omar, Krammer, Christine, Sinitski, Dzmitry, Hille, Kathleen, Zan, Chunfang, Yan, Guangyao, Wang, Sijia, Gao, Ying, Brandhofer, Markus, Megens, Remco T. A., Hoffmann, Adrian, Pauli, Jessica, Asare, Yaw, Gerra, Simona, Bourilhon, Priscila, Leng, Lin, Eckstein, Hans-Henning, Kempf, Wolfgang E., Pelisek, Jaroslav, Gokce, Ozgun, Maegdefessel, Lars, Bucala, Richard, Dichgans, Martin, Weber, Christian, Kapurniotu, Aphrodite, Bernhagen, Jürgen

“…Targeting a specific chemokine/receptor axis in atherosclerosis remains challenging. Soluble receptor-based strategies are not established for chemokine…”
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Macrophage migration inhibitory factor exerts pro‐proliferative and anti‐apoptotic effects via CD74 in murine hepatocellular carcinoma by Wirtz, Theresa H., Saal, Alena, Bergmann, Irina, Fischer, Petra, Heinrichs, Daniel, Brandt, Elisa F., Koenen, Maria T., Djudjaj, Sonja, Schneider, Kai M., Boor, Peter, Bucala, Richard, Weiskirchen, Ralf, Bernhagen, Jürgen, Trautwein, Christian, Berres, Marie‐Luise

“…Background and Purpose Macrophage migration inhibitory factor (MIF) is an inflammatory and chemokine‐like protein expressed in different inflammatory diseases…”
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Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas by Cheng, Feng, Zhu, Leilei, Lue, Hongqi, Bernhagen, Jürgen, Schwaneberg, Ulrich

“…Arginine deiminase (ADI) is a therapeutic protein for cancer therapy of arginine-auxotrophic tumors. However, ADI’s application as anticancer drug is hampered…”
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Macrophage Migration Inhibitory Factor Limits Renal Inflammation and Fibrosis by Counteracting Tubular Cell Cycle Arrest by Djudjaj, Sonja, Martin, Ina V, Buhl, Eva M, Nothofer, Nina J, Leng, Lin, Piecychna, Marta, Floege, Jürgen, Bernhagen, Jürgen, Bucala, Richard, Boor, Peter

“…Renal fibrosis is a common underlying process of progressive kidney diseases. We investigated the role of macrophage migration inhibitory factor (MIF), a…”
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Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells by Spiller, Lukas, Manjula, Ramu, Leissing, Franz, Basquin, Jerome, Bourilhon, Priscila, Sinitski, Dzmitry, Brandhofer, Markus, Levecque, Sophie, Gerra, Simona, Sabelleck, Björn, Zhang, Lin, Feederle, Regina, Flatley, Andrew, Hoffmann, Adrian, Panstruga, Ralph, Bernhagen, Jürgen, Lolis, Elias

“…Mammalian macrophage migration inhibitory factor (MIF) and its paralog, D-dopachrome tautomerase, are multifunctional inflammatory cytokines. Plants have…”
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Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability by Asare, Yaw, Campbell-James, Thomas A., Bokov, Yury, Yu, Lydia Luya, Prestel, Matthias, El Bounkari, Omar, Roth, Stefan, Megens, Remco T.A., Straub, Tobias, Thomas, Kyra, Yan, Guangyao, Schneider, Melanie, Ziesch, Natalie, Tiedt, Steffen, Silvestre-Roig, Carlos, Braster, Quinte, Huang, Yishu, Schneider, Manuela, Malik, Rainer, Haffner, Christof, Liesz, Arthur, Soehnlein, Oliver, Bernhagen, Jürgen, Dichgans, Martin

“…RATIONALE:Arterial inflammation manifested as atherosclerosis is the leading cause of mortality worldwide. Genome-wide association studies have identified a…”
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