Search Results - "Berney, Xavier"
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Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion
Published in Nature communications (30-09-2022)“…The counterregulatory response to hypoglycemia that restores normal blood glucose levels is an essential physiological function. It is initiated, in large…”
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α-cell glucokinase suppresses glucose-regulated glucagon secretion
Published in Nature communications (07-02-2018)“…Glucagon secretion by pancreatic α-cells is triggered by hypoglycemia and suppressed by high glucose levels; impaired suppression of glucagon secretion is a…”
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Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo
Published in PloS one (14-11-2012)“…Plac8 belongs to an evolutionary conserved family of proteins, mostly abundant in plants where they control fruit weight through regulation of cell number. In…”
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Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion
Published in Molecular metabolism (Germany) (01-07-2022)“…Glucagon secretion to stimulate hepatic glucose production is the first line of defense against hypoglycemia. This response is triggered by so far incompletely…”
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A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion
Published in Cell reports (Cambridge) (08-11-2016)“…The counterregulatory response to hypoglycemia, which restores normal blood glucose levels to ensure sufficient provision of glucose to the brain, is critical…”
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A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion
Published in Molecular metabolism (Germany) (01-07-2020)“…Glucose-stimulated insulin secretion is a critical function in the regulation of glucose homeostasis, and its deregulation is associated with the development…”
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Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion
Published in Molecular metabolism (Germany) (01-04-2017)“…Abstract Objective In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In…”
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Klf6 protects β-cells against insulin resistance-induced dedifferentiation
Published in Molecular metabolism (Germany) (01-05-2020)“…In the pathogenesis of type 2 diabetes, development of insulin resistance triggers an increase in pancreatic β-cell insulin secretion capacity and β-cell…”
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Fgf15 neurons of the dorsomedial hypothalamus control glucagon secretion and hepatic gluconeogenesis
Published in Diabetes (New York, N.Y.) (01-07-2021)“…The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose responsive neurons,…”
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Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia
Published in EMBO reports (03-08-2023)“…The counterregulatory response to hypoglycemia (CRR), which ensures a sufficient glucose supply to the brain, is an essential survival function. It is…”
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Plac8 Is an Inducer of C/EBPβ Required for Brown Fat Differentiation, Thermoregulation, and Control of Body Weight
Published in Cell metabolism (02-11-2011)“…Brown adipocytes oxidize fatty acids to produce heat in response to cold or to excessive energy intake; stimulation of brown fat development and function may…”
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