Gloves and socks syndrome: Early and late histopathologic features

Gloves and socks syndrome: Early and late histopathologic features

Background: Gloves and socks syndrome (GSS) is a recently described exanthem, most commonly caused by parvovirus B19. Objective: Our purpose was to describe both early and late histopathologic features of GSS. Methods: We performed histopathologic examination of biopsy specimens from a case of GSS a...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology Vol. 47; no. 5; pp. 749 - 754
Main Authors: Smitha, Sidney B., Libowa, Lester F., Elstona, Dirk M., Bernerta, Richard A., Warschaw, Karen E.
Format: Journal Article
Language:English
Published: New York, NY Mosby, Inc 01-11-2002
Elsevier
Subjects:
Adult
Biological and medical sciences
Biopsy
Dermatology
Exanthema - pathology
Exanthema - virology
Fluorescent Antibody Technique
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Skin involvement in other diseases. Miscellaneous. General aspects
Syndrome
Human
Skin disease
Late
Exanthema
Characteristic
Clinical form
Exploration
Male
Erythrovirus
Virus B19
Virus
Case study
Pathology
Gloves and socks syndrome
Histopathology
Parvoviridae
Young adult
Early
Diagnosis
Comparative study
Bibliographic review
Parvovirinae
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Summary:Background: Gloves and socks syndrome (GSS) is a recently described exanthem, most commonly caused by parvovirus B19. Objective: Our purpose was to describe both early and late histopathologic features of GSS. Methods: We performed histopathologic examination of biopsy specimens from a case of GSS and reviewed all the English-language literature reports of GSS to compare the reported histologic descriptions. Results: A total of 46 cases of GSS have been reported in the English-language literature. In 18 of those, the pathologic features were described. The histologic features of the current case evolved from a nonspecific superficial perivascular lymphocytic infiltrate to a vacuolar interface dermatitis with necrotic keratinocytes, erythrocyte extravasation, and a superficial perivascular and interstitial lymphocytic infiltrate. Conclusion: Early lesions of GSS show nonspecific features common to viral exanthems. The late features, of a fully evolved exanthem, demonstrate a vacuolar interface dermatitis with necrotic keratinocytes, a superficial perivascular and interstitial infiltrate, and dermal hemorrhage. These late pathologic features, together with the clinical appearance of GSS, may help distinguish it from other entities. (J Am Acad Dermatol 2002;47:749-54.)
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
ISSN:0190-9622
1097-6787
DOI:10.1067/mjd.2002.124612