Search Results - "Berndt, Nikolaus"

Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammation by Chausse, Bruno, Malorny, Nikolai, Lewen, Andrea, Poschet, Gernot, Berndt, Nikolaus, Kann, Oliver

“…Microglia, brain-resident macrophages, can acquire distinct functional phenotypes, which are supported by differential reprogramming of cell metabolism. These…”
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Metabolic Adaptation in Epilepsy: From Acute Response to Chronic Impairment by Liotta, Agustin, Loroch, Stefan, Wallach, Iwona, Klewe, Kristoffer, Marcus, Katrin, Berndt, Nikolaus

“…Epilepsy is characterized by hypersynchronous neuronal discharges, which are associated with an increased cerebral metabolic rate of oxygen and ATP demand…”
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Functional Consequences of Metabolic Zonation in Murine Livers: Insights for an Old Story by Berndt, Nikolaus, Kolbe, Erik, Gajowski, Robert, Eckstein, Johannes, Ott, Fritzi, Meierhofer, David, Holzhütter, Hermann‐Georg, Matz‐Soja, Madlen

“…Background and Aims Zone‐dependent differences in expression of metabolic enzymes along the portocentral axis of the acinus are a long‐known feature of liver…”
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Dynamic Metabolic Zonation of the Hepatic Glucose Metabolism Is Accomplished by Sinusoidal Plasma Gradients of Nutrients and Hormones by Berndt, Nikolaus, Holzhütter, Hermann-Georg

“…Being the central metabolic organ of vertebrates, the liver possesses the largest repertoire of metabolic enzymes among all tissues and organs. Almost all…”
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HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology by Berndt, Nikolaus, Bulik, Sascha, Wallach, Iwona, Wünsch, Tilo, König, Matthias, Stockmann, Martin, Meierhofer, David, Holzhütter, Hermann-Georg

“…The epidemic increase of non-alcoholic fatty liver diseases (NAFLD) requires a deeper understanding of the regulatory circuits controlling the response of…”
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The importance of membrane microdomains for bile salt-dependent biliary lipid secretion by Eckstein, Johannes, Holzhütter, Hermann-Georg, Berndt, Nikolaus

“…Alternative models explaining the biliary lipid secretion at the canalicular membrane of hepatocytes exist: successive lipid extraction by preformed bile salt…”
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A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism by Berndt, Nikolaus, Horger, Marius Stefan, Bulik, Sascha, Holzhütter, Hermann-Georg

“…The capacity of the liver to convert the metabolic input received from the incoming portal and arterial blood into the metabolic output of the outgoing venous…”
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Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors by Wei, Xiaoyan, Rigopoulos, Angelos, Lienhard, Matthias, Pöhle-Kronawitter, Sophie, Kotsaris, Georgios, Franke, Julia, Berndt, Nikolaus, Mejedo, Joy Orezimena, Wu, Hao, Börno, Stefan, Timmermann, Bernd, Murgai, Arunima, Glauben, Rainer, Stricker, Sigmar

“…Patients affected by neurofibromatosis type 1 (NF1) frequently show muscle weakness with unknown etiology. Here we show that, in mice, Neurofibromin 1 ( Nf1 )…”
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Correction: The importance of membrane microdomains for bile salt-dependent biliary lipid secretion (doi:10.1242/jcs.211524) by Eckstein, Johannes, Holzhütter, Hermann-Georg, Berndt, Nikolaus

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A novel variant of the 13C-methacetin liver function breath test that eliminates the confounding effect of individual differences in systemic CO2 kinetics by Holzhütter, Hermann-Georg, Wuensch, Tilo, Gajowski, Robert, Berndt, Nikolaus, Bulik, Sascha, Meierhofer, David, Stockmann, Martin

“…The principle of dynamic liver function breath tests is founded on the administration of a 13 C-labeled drug and subsequent monitoring of 13 CO 2 in the…”
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Sevoflurane Effects on Neuronal Energy Metabolism Correlate with Activity States While Mitochondrial Function Remains Intact by Maechler, Mathilde, Rösner, Jörg, Wallach, Iwona, Geiger, Joerg R P, Spies, Claudia, Liotta, Agustin, Berndt, Nikolaus

“…During general anesthesia, alterations in neuronal metabolism may induce neurotoxicity and/or neuroprotection depending on the dose and type of the applied…”
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Characterization of Lipid and Lipid Droplet Metabolism in Human HCC by Berndt, Nikolaus, Eckstein, Johannes, Heucke, Niklas, Gajowski, Robert, Stockmann, Martin, Meierhofer, David, Holzhütter, Hermann-Georg

“…Human hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and the most common cause of death in people with cirrhosis…”
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Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC by Kroh, Andreas, Walter, Jeanette, Fragoulis, Athanassios, Möckel, Diana, Lammers, Twan, Kiessling, Fabian, Andruszkow, Julia, Preisinger, Christian, Egbert, Maren, Jiao, Long, Eickhoff, Roman M, Heise, Daniel, Berndt, Nikolaus, Cramer, Thorsten, Neumann, Ulf Peter, Egners, Antje, Ulmer, Tom Florian

“…Obesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in…”
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Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease by Berndt, Nikolaus, Hudert, Christian A., Eckstein, Johannes, Loddenkemper, Christoph, Henning, Stephan, Bufler, Philip, Meierhofer, David, Sack, Ingolf, Wiegand, Susanna, Wallach, Iwona, Holzhütter, Hermann-Georg

“…Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and is associated with overweight and insulin resistance (IR)…”
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The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism--insights from mathematical modeling by Bulik, Sascha, Holzhütter, Hermann-Georg, Berndt, Nikolaus

“…Adaptation of the cellular metabolism to varying external conditions is brought about by regulated changes in the activity of enzymes and transporters…”
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Flavin Adenine Dinucleotide Fluorescence as an Early Marker of Mitochondrial Impairment During Brain Hypoxia by Berndt, Nikolaus, Kovács, Richard, Rösner, Jörg, Wallach, Iwona, Dreier, Jens P, Liotta, Agustin

“…Multimodal continuous bedside monitoring is increasingly recognized as a promising option for early treatment stratification in patients at risk for ischemia…”
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Computational Hypothesis: How Intra-Hepatic Functional Heterogeneity May Influence the Cascading Progression of Free Fatty Acid-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Holzhütter, Hermann-Georg, Berndt, Nikolaus

“…Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common type of chronic liver disease in developed nations, affecting around 25% of the population…”
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Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer by Berndt, Nikolaus, Egners, Antje, Mastrobuoni, Guido, Vvedenskaya, Olga, Fragoulis, Athanassios, Dugourd, Aurélien, Bulik, Sascha, Pietzke, Matthias, Bielow, Chris, van Gassel, Rob, Damink, Steven W. Olde, Erdem, Merve, Saez-Rodriguez, Julio, Holzhütter, Hermann-Georg, Kempa, Stefan, Cramer, Thorsten

“…Background Metabolic alterations can serve as targets for diagnosis and cancer therapy. Due to the highly complex regulation of cellular metabolism, definite…”
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Bioenergetic Mechanisms of Seizure Control by Kovács, Richard, Gerevich, Zoltan, Friedman, Alon, Otáhal, Jakub, Prager, Ofer, Gabriel, Siegrun, Berndt, Nikolaus

“…Epilepsy is characterized by the regular occurrence of seizures, which follow a stereotypical sequence of alterations in the electroencephalogram. Seizures are…”
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Pregnancy alters fatty acid metabolism, glucose regulation, and detoxification of the liver in synchrony with biomechanical property changes by Guo, Jing, Krehl, Karolina, Safraou, Yasmine, Wallach, Iwona, Braun, Jürgen, Meierhofer, David, Sack, Ingolf, Berndt, Nikolaus

“…Pregnancy places a metabolic burden on the body including the liver, which is responsible for ensuring adequate nutrition for the maternal and fetal systems…”
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