Search Results - "Bernd Nürnberg"

Analyses of Gnai3-iresGFP reporter mice reveal unknown Gαi3 expression sites by Leiss, Veronika, Reisinger, Ellen, Speidel, Annika, Beer-Hammer, Sandra, Nürnberg, Bernd

“…Inhibitory G proteins (G i proteins) are highly homologous but play distinct biological roles. However, their isoform-specific detection remains challenging…”
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Vasopressin-stimulated ORAI1 expression and store-operated Ca2+ entry in aortic smooth muscle cells by Zhu, Xuexue, Ma, Ke, Zhou, Kuo, Liu, Jibin, Nürnberg, Bernd, Lang, Florian

“…Vascular calcification may result from stimulation of osteogenic signalling with upregulation of the transcription factors CBFA1 , MSX2 and SOX9 , as well as…”
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Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels by Dembla, Sandeep, Behrendt, Marc, Mohr, Florian, Goecke, Christian, Sondermann, Julia, Schneider, Franziska M, Schmidt, Marlene, Stab, Julia, Enzeroth, Raissa, Leitner, Michael G, Nuñez-Badinez, Paulina, Schwenk, Jochen, Nürnberg, Bernd, Cohen, Alejandro, Philipp, Stephan E, Greffrath, Wolfgang, Bünemann, Moritz, Oliver, Dominik, Zakharian, Eleonora, Schmidt, Manuela, Oberwinkler, Johannes

“…Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically available. Their action includes a strong central component, which…”
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Role of TRPC6 in kidney damage after acute ischemic kidney injury by Zheng, Zhihuang, Tsvetkov, Dmitry, Bartolomaeus, Theda Ulrike Patricia, Erdogan, Cem, Krügel, Ute, Schleifenbaum, Johanna, Schaefer, Michael, Nürnberg, Bernd, Chai, Xiaoning, Ludwig, Friedrich-Alexander, N’diaye, Gabriele, Köhler, May-Britt, Wu, Kaiyin, Gollasch, Maik, Markó, Lajos

“…Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation channel that controls influx of Ca 2+ and other monovalent cations…”
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Function, Regulation and Biological Roles of PI3Kγ Variants by Nürnberg, Bernd, Beer-Hammer, Sandra

“…Phosphatidylinositide 3-kinase (PI3K) γ is the only class IB PI3K member playing significant roles in the G-protein-dependent regulation of cell signaling in…”
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Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4 by van Geffen, Chiel, Deißler, Astrid, Beer-Hammer, Sandra, Nürnberg, Bernd, Handgretinger, Rupert, Renz, Harald, Hartl, Dominik, Kolahian, Saeed

“…Emerging evidence suggests a mechanistic role for myeloid-derived suppressor cells (MDSCs) in lung diseases like asthma. Previously, we showed that adoptive…”
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Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses by Lee, Jihyung, Zhang, Junyan, Chung, Young-Jun, Kim, Jun Hwan, Kook, Chae Min, González-Navajas, José M, Herdman, David S, Nürnberg, Bernd, Insel, Paul A, Corr, Maripat, Mo, Ji-Hun, Tao, Ailin, Yasuda, Kei, Rifkin, Ian R, Broide, David H, Sciammas, Roger, Webster, Nicholas Jg, Raz, Eyal

“…Cyclic AMP (cAMP) is involved in many biological processes but little is known regarding its role in shaping immunity. Here we show that cAMP-PKA-CREB…”
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Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs) by Vadas, Oscar, Dbouk, Hashem A., Shymanets, Aliaksei, Perisic, Olga, Burke, John E., Saab, Widian F. Abi, Khalil, Bassem D., Harteneck, Christian, Bresnick, Anne R., Nürnberg, Bernd, Backer, Jonathan M., Williams, Roger L.

“…Phosphoinositide 3-kinase gamma (PI3Kγ) has profound roles downstream of G-protein–coupled receptors in inflammation, cardiac function, and tumor progression…”
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Effect of MgCl2 and GdCl3 on ORAI1 Expression and Store-Operated Ca2+ Entry in Megakaryocytes by Zhou, Kuo, Zhu, Xuexue, Ma, Ke, Liu, Jibin, Nürnberg, Bernd, Gawaz, Meinrad, Lang, Florian

“…In chronic kidney disease, hyperphosphatemia upregulates the Ca2+ channel ORAI and its activating Ca2+ sensor STIM in megakaryocytes and platelets. ORAI1 and…”
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Stimulation of ORAI1 expression, store-operated Ca2+ entry, and osteogenic signaling by high glucose exposure of human aortic smooth muscle cells by Ma, Ke, Sukkar, Basma, Zhu, Xuexue, Zhou, Kuo, Cao, Hang, Voelkl, Jakob, Alesutan, Ioana, Nürnberg, Bernd, Lang, Florian

“…Diabetes and chronic kidney disease (CKD) both trigger vascular osteogenic signaling and calcification leading to early death by cardiovascular events…”
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Development of First Lead Structures for Phosphoinositide 3‑Kinase-C2γ Inhibitors by Freitag, Anne, Prajwal, Prajwal, Shymanets, Aliaksei, Harteneck, Christian, Nürnberg, Bernd, Schächtele, Christoph, Kubbutat, Michael, Totzke, Frank, Laufer, Stefan A.

“…The importance of complete elucidation of the biological functions of phosphoinositide 3-kinases (PI3K) was realized years ago. They generate…”
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Cerebrovascular Gi Proteins Protect Against Brain Hypoperfusion and Collateral Failure in Cerebral Ischemia by Castaneda-Vega, Salvador, Beer-Hammer, Sandra, Leiss, Veronika, Napieczyńska, Hanna, Vuozzo, Marta, Schmid, Andreas M., Zeng, Hang, He, Yi, Kohlhofer, Ursula, Gonzalez-Menendez, Irene, Quintanilla-Martinez, Leticia, Hempel, Johann-Martin, Gollasch, Maik, Yu, Xin, Pichler, Bernd J., Nürnberg, Bernd

“…Cerebral hypoperfusion and vascular dysfunction are closely related to common risk factors for ischemic stroke such as hypertension, dyslipidemia, diabetes,…”
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Platelet Gᵢ protein Gαᵢ₂ is an essential mediator of thrombo-inflammatory organ damage in mice by Devanathan, Vasudharani, Hagedorn, Ina, Köhler, David, Pexa, Katja, Cherpokova, Deya, Kraft, Peter, Singh, Madhurendra, Rosenberger, Peter, Stoll, Guido, Birnbaumer, Lutz, Piekorz, Roland P, Beer-Hammer, Sandra, Nieswandt, Bernhard, Nürnberg, Bernd

“…Platelets are crucial for hemostasis and thrombosis and exacerbate tissue injury following ischemia and reperfusion. Important regulators of platelet function…”
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Requirement of Na+/H+ Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells by Zhu, Xuexue, Ma, Ke, Zhou, Kuo, Pan, Xia, Liu, Jibin, Nürnberg, Bernd, Alesutan, Ioana, Völkl, Jakob, Lang, Florian

“…Background/Aims: Vasopressin is a powerful stimulator of vascular calcification, augmenting osteogenic signaling in vascular smooth muscle cells (VSMCs)…”
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Gαi2 Signaling Is Required for Skeletal Muscle Growth, Regeneration, and Satellite Cell Proliferation and Differentiation by Minetti, Giulia C., Feige, Jerome N., Bombard, Florian, Heier, Annabelle, Morvan, Fredric, Nürnberg, Bernd, Leiss, Veronika, Birnbaumer, Lutz, Glass, David J., Fornaro, Mara

“…OA  Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Anti-inflammatory role of CD11b+Ly6G+ neutrophilic cells in allergic airway inflammation in mice by Nowroozilarki, Negar, Öz, Hasan Halit, Schroth, Carolin, Hector, Andreas, Nürnberg, Bernd, Hartl, Dominik, Kolahian, Saeed

“…•Adoptively transferred of CD11b+Ly6G+ neutrophilic cells are recruited to the lung.•Adoptive transfer of CD11b+Ly6G+ neutrophilic cells attenuate Th2 and Th17…”
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Corrigendum to “Lack of Gαi2 proteins in adipocytes attenuates diet-induced obesity” [Mol Metab 40 (2020 Oct) 101029] by Leiss, Veronika, Schönsiegel, Annika, Gnad, Thorsten, Kerner, Johannes, Kaur, Jyotsna, Sartorius, Tina, Machann, Jürgen, Schick, Fritz, Birnbaumer, Lutz, Häring, Hans-Ulrich, Pfeifer, Alexander, Nürnberg, Bernd

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Roles of Gβγ in Membrane Recruitment and Activation of P110γ/P101 Phosphoinositide 3-Kinase γ by Brock, Carsten, Schaefer, Michael, Reusch, H. Peter, Czupalla, Cornelia, Michalke, Manuela, Spicher, Karsten, Schultz, Günter, Nürnberg, Bernd

“…Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P2 to PtdIns-3,4,5-P3. This, in…”
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mRNA-Mediated Gene Supplementation of Toll-Like Receptors as Treatment Strategy for Asthma In Vivo by Zeyer, Franziska, Mothes, Benedikt, Will, Clara, Carevic, Melanie, Rottenberger, Jennifer, Nürnberg, Bernd, Hartl, Dominik, Handgretinger, Rupert, Beer-Hammer, Sandra, Kormann, Michael S D

“…Asthma is the most common chronic disease in childhood. Although several therapeutic options are currently available to control the symptoms, many drugs have…”
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Selective protection of murine cerebral Gi/o-proteins from inactivation by parenterally injected pertussis toxin by Vega, Salvador Castaneda, Leiss, Veronika, Piekorz, Roland, Calaminus, Carsten, Pexa, Katja, Vuozzo, Marta, Schmid, Andreas M., Devanathan, Vasudharani, Kesenheimer, Christian, Pichler, Bernd J., Beer-Hammer, Sandra, Nürnberg, Bernd

“…Pertussis toxin (PTX) is a potent virulence factor in patients suffering from whooping cough, but in its detoxified version, it is applied for vaccination. It…”
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