Search Results - "Bernardino, Thaissa Consoni"
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Biochemical monitoring of SARS-CoV-2 VLP production stages using MIR spectroscopy and chemometrics
Published in Process biochemistry (1991) (01-12-2024)“…Among vaccine platforms against SARS-CoV-2, the virus-like particles (VLP) hold advantageous immunological and safety attributes. Furthermore, there are…”
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Comparison of chemometric models using Raman spectroscopy for offline biochemical monitoring throughout the VLP-making upstream process
Published in Biochemical engineering journal (01-09-2023)“…This work aimed to compare the predictive capacity of linear (Partial Least Squares; Principal Component Regression) and non-linear (Artificial Neural Network,…”
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Laser wavelength and sample conditioning effects on biochemical monitoring of SARS-CoV-2 VLP production upstream stage by Raman spectroscopy
Published in Biochemical engineering journal (01-11-2024)“…This work assessed the impact of laser wavelength and sample conditioning on offline monitoring (viable cell density, cell viability, virus titer, glucose,…”
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Different modeling approaches for inline biochemical monitoring over the VLP-making upstream stages using Raman spectroscopy
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (05-11-2024)“…[Display omitted] •Monitoring of Rabies virus-like particles production using online Raman spectra.•Nonlinear models showed a better fit than linear ones in…”
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Biochemical monitoring throughout all stages of rabies virus-like particles production by Raman spectroscopy using global models
Published in Journal of biotechnology (10-02-2023)“…This work aimed to quantify growth and biochemical parameters (viable cell density, Xv; cell viability, CV; glucose, lactate, glutamine, glutamate, ammonium,…”
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Monitoring by Raman spectroscopy of rabies virus‐like particles production since the initial development stages
Published in Journal of chemical technology and biotechnology (1986) (01-03-2024)“…BACKGROUND This study aimed to establish chemometric models using Raman spectroscopy data for biochemical monitoring of rabies Virus‐Like Particles (VLP)…”
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Oxygen uptake and transfer rates throughout production of recombinant baculovirus and rabies virus-like particles
Published in Process biochemistry (1991) (01-01-2023)“…The technologies used in rabies vaccines manufacturing for human use are based on the inactivated virus platform. An alternative to traditional vaccines is…”
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Production of Rabies VLPs in Insect Cells by Two Monocistronic Baculoviruses Approach
Published in Molecular biotechnology (01-11-2021)“…Rabies is an ancient zoonotic disease that still causes the death of over 59,000 people worldwide each year. The rabies lyssavirus encodes five proteins,…”
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Inline Raman spectroscopy as process analytical technology for SARS-CoV-2 VLP production
Published in Bioprocess and biosystems engineering (09-10-2024)“…The present work focused on inline Raman spectroscopy monitoring of SARS-CoV-2 VLP production using two culture media by fitting chemometric models for…”
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Zika virus-like particles (VLPs) produced in insect cells
Published in Frontiers in pharmacology (12-06-2023)“…The Zika virus (ZIKV) infections are a healthcare concern mostly in the Americas, Africa, and Asia but have increased its endemicity area beyond these…”
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Semliki Forest Virus replicon particles production in serum-free medium BHK-21 cell cultures and their use to express different proteins
Published in Cytotechnology (Dordrecht) (01-10-2019)“…The production of biopharmaceuticals as vaccines in serum-free media results in reduced risk of contamination and simpler downstream processing. The production…”
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Performance Comparison of Recombinant Baculovirus and Rabies Virus-like Particles production Using Two Culture Platforms
Published in Vaccines (Basel) (24-12-2022)“…This work aimed to assess, following upstream optimization in Schott flasks, the scalability from this culture platform to a stirred-tank bioreactor in order…”
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Raman laser intensity and sample clarification on biochemical monitoring over Zika-VLP upstream stages
Published in Biochemical and biophysical research communications (12-11-2024)“…In the current biopharmaceutical scenario, constant bioprocess monitoring is crucial for the quality and integrity of final products. Thus, process analytical…”
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Sf9 Cells Metabolism and Viability When Coinfected with Two Monocistronic Baculoviruses to Produce Rabies Virus-like Particles
Published in Molecular biotechnology (01-06-2023)“…This work aimed to describe the dynamics of the Sf9 insect cells death and primary metabolism when this host is infected simultaneously by two recombinant…”
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Chemometrics and analytical blank on the at-line monitoring of Zika-VLP production using near-infrared spectroscopy
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (05-02-2025)“…[Display omitted] •Water as an analytical blank is more suitable for Zika-VLP monitoring using NIR.•Cell remotion and spectral filtering are not necessary to…”
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Sf9 Cell Metabolism Throughout the Recombinant Baculovirus and Rabies Virus-Like Particles Production in Two Culture Systems
Published in Molecular biotechnology (01-02-2024)“…This work aimed to assess the Sf9 cell metabolism during growth, and infection steps with recombinant baculovirus bearing rabies virus proteins, to finally…”
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Intracellular Delivery of HCV NS3p gene using vectored particles
Published in Journal of biotechnology (20-05-2018)“…•We implemented of technology for the production of vectored particles carrying Hepatitis C nonstructural protein 3.•The field strength is one the most…”
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Larval development of Simulium (Chirostilbia) pertinax (Diptera: Simuliidae) in an artificial breeding site
Published in Neotropical biology and conservation (27-09-2011)Get full text
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