Search Results - "Bernardino, Alice M. R."

Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives by dos Santos, Maurício S, Oliveira, Mariana L.V, Bernardino, Alice M.R, de Léo, Rosa M, Amaral, Veronica F, de Carvalho, Flavia T, Leon, Leonor L, Canto-Cavalheiro, Marilene M

“…A series of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazoles (4a–g) and 5-amino-1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazoles (5a–g) were…”
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Identification of a Potential Lead Structure for Designing New Antimicrobials to Treat Infections Caused by Staphylococcus epidermidis-Resistant Strains by Pinheiro, Luiz C. S, Abreu, Paula A, Afonso, Ilidio F, Leal, Bruno, Corrêa, Luiz C. D, Borges, Júlio C, Marques, Isakelly P, Lourenço, André L, Sathler, Plinio, dos Santos, Andre L, Medeiros, Cid A, Cabral, Lúcio M, Júnior, Maurício L. O, Romeiro, Gilberto A, Ferreira, Vitor F, Rodrigues, Carlos R, Castro, Helena C, Bernardino, Alice M. R

“…Bacterial infections are a significant cause of morbidity and mortality among critically ill patients. The increase of antibiotic resistance in bacteria from…”
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4-(1H-Pyrazol-1-yl) benzenesulfonamide derivatives: identifying new active antileishmanial structures for use against a neglected disease by Marra, Roberta K F, Bernardino, Alice M R, Proux, Tathiane A, Charret, Karen S, Lira, Marie-Luce F, Castro, Helena C, Souza, Alessandra M T, Oliveira, Cesar D, Borges, Júlio C, Rodrigues, Carlos R, Canto-Cavalheiro, Marilene M, Leon, Leonor L, Amaral, Veronica F

“…Leishmaniasis is a neglected disease responsible for about 56,000 deaths every year. Despite its importance, there are no effective, safe and proper treatments…”
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SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series by BERNARDINO, Alice M. R, CASTRO, Helena C, ALBUQUERQUE, Magaly G, CABRAL, Lucio M, RODRIGUES, Carlos R, FRUGULHETTI, Izabel C. P. P, LOUREIRO, Natalia I. V, AZEVEDO, Alexandre R, PINHEIRO, Luiz C. S, SOUZA, Thiago M. L, GIONGO, Viveca, PASSAMANI, Fabiana, MAGALHAES, Uiaran O

“…Herpes Simplex Virus (HSV) infections are among the most common human diseases. In this work, we assess the structural features and electronic properties of a…”
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Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives by Leal, Bruno, Afonso, Ilídio F, Rodrigues, Carlos R, Abreu, Paula A, Garrett, Rafael, Pinheiro, Luiz Carlos S, Azevedo, Alexandre R, Borges, Julio C, Vegi, Percilene F, Santos, Cláudio C C, da Silveira, Francisco C A, Cabral, Lúcio M, Frugulhetti, Izabel C P P, Bernardino, Alice M R, Santos, Dilvani O, Castro, Helena C

“…Antibacterial resistance is a complex problem that contributes to health and economic losses worldwide. The Staphylococcus epidermidis is an important…”
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Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis by Charret, Karen S, Rodrigues, Raquel F, Bernardino, Alice M. R, Gomes, Adriana O, Carvalho, Adriana V, Canto-Cavalheiro, Marilene M, Leon, Leonor, Amaral, Veronica F

“…Newly synthesized pyrazole carbohydrazide derivatives with substituents X = Br/Y = NO(2) and X = NO(2)/Y = Cl were independently investigated in the CBA mouse…”
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Synthesis, Crystal Structures, and in Silico Toxicity Prediction of Thienopyridine Phosphoramidates by Pedrosa, Leandro F., de Macedo, William P., Furtado, Antonia C. R., Guedes, Guilherme P., Pinheiro, Luiz C. S., Resende, Jackson A. L. C., Vaz, Maria G. F., Bernardino, Alice M. R., de Souza, Marcos C.

“…New thieno[2,3-b]pyridine phosphoramidates compounds were synthesized and characterized by infrared; 1 H, 13 C, and 31 P NMR spectroscopy; and high-resolution…”
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Design, synthesis and anti-P. falciparum activity of pyrazolopyridine–sulfonamide derivatives by Silva, Thais B., Bernardino, Alice M.R., Ferreira, Maria de Lourdes G., Rogerio, Kamilla R., Carvalho, Leonardo J.M., Boechat, Nubia, Pinheiro, Luiz C.S.

“…[Display omitted] Ten 1-phenyl-1H-pyrazolo[3,4-b]pyridine derivatives connected by a linker group to benzenesulfonamide moieties with different substituents in…”
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N-(4-Chloro-phen-yl)-5-(4,5-dihydro-1H-imidazol-2-yl)thieno[2,3-b]pyridin-4-amine by Bernardino, Alice M R, Pinheiro, Luiz C S, Tiekink, Edward R T, Wardell, James L, Wardell, Solange M S V

“…In the title compound, C(16)H(13)ClN(4)S, the thienopyridine fused-ring system is nearly planar (r.m.s. deviation = 0.0333 Å) and forms a dihedral angle of 4.4…”
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Synthesis and activity of novel tetrazole compounds and their pyrazole-4-carbonitrile precursors against Leishmania spp by Faria, Jéssica V., dos Santos, Maurício S., Bernardino, Alice M.R., Becker, Klaus M., Machado, Gérzia M.C., Rodrigues, Raquel F., Canto-Cavalheiro, Marilene M., Leon, Leonor L.

“…A series of 5-(1-aryl-3-methyl-1H-pyrazol-4-yl)-1H-tetrazole derivatives (4a–m) and their 1-aryl-3-methyl-1H-pyrazole-4-carbonitriles (3a–m) precursors were…”
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Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis by Faria, Jessica V, Passos, Fernanda P Z, da Costa, Paulo H A, de Oliveira, Andressa P, Cruz, Yasmin O D da, Castelo-Branco, Frederico S, Lourenço, Maria C S, Murta, Silvane M F, Junior, Policarpo A S, Bernardino, Alice M R, Bastos, Monica M, Boechat, Nubia

“…Tuberculosis (TB) is one of the top ten causes of death worldwide, while Chagas disease (CD) is the parasitic disease that kills the largest number of people…”
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A New Quartz-like Metal–Organic Framework Constructed from a Versatile Pyrazole-Based Spacer by Guedes, Guilherme P, Santos, Igor F, Mercante, Luiza A, Speziali, Nivaldo L, Resende, Jackson A. L. C, Bernardino, Alice M. R, Andruh, Marius, Vaz, Maria G. F

“…Two new coordination polymers, 1 ∞[Cu2(L)4­(MeOH)]­·MeOH (1) and 3 ∞[Cu(L)2]­·5H2O (2), have been obtained exploring the potential of…”
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Novel 4‐arylaminoquinoline‐3‐carbonitriles as Inhibitors of HIV‐1 Reverse Transcriptase by Melo, Beatriz C. L., Bernardino, Alice M. R., Polillo, Gustavo, Pereira, Helena S., Paixão, Izabel C. P., Ribeiro, Michele S., Borges, Julio C.

“…This paper describes the synthesis of several new 4‐arylaminoquinoline‐3‐carbonitriles derivatives. These were evaluated on the activity reverse transcriptase…”
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Synthesis, crystal structure, magnetic properties and DFT calculations of a mononuclear copper(II) complex: Relevance of halogen bonding for magnetic interaction by Silva, Cassiano P., Junior, Henrique C.S., Santos, Igor F., Bernardino, Alice M.R., Cassaro, Rafael A.A., Novak, Miguel A., Vaz, Maria G.F., Guedes, Guilherme P.

“…[Display omitted] •Mononuclear copper(II) compound containing a pyrazol-based ligand.•Short contact N–H⋯Cl plays a key role to the magnetic…”
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Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N'-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides by BERNARDINO, Alice M. R, GOMES, Adriana O, CHARRET, Karen S, FREITAS, Antonio C. C, MACHADO, Gérzia M. C, CANTO-CAVALHEIRO, Marilene M, LEON, Leonor L, AMARAL, Veronica F

“…1H-pyrazole-4-carbohydrazides were synthesized and their leishmanicidal in vitro activities and cytotoxic effects were investigated. The drugs prototypes of…”
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An Efficient Synthesis of New 5-(1-Aryl-1H-pyrazole-4-yl)-1H-tetrazoles from 1-Aryl-1H-pyrazole-4-carbonitriles via [3 + 2] Cycloaddition Reaction by dos Santos, Maurício S., Bernardino, Alice M. R., Pinheiro, Luiz C. S., Canto-Cavalheiro, Marilene M., Leon, Leonor L.

“…A series of new 5‐(1‐aryl‐1H‐pyrazole‐4‐yl)‐1H‐tetrazoles 4a‐l were synthesized via [3 + 2] cycloaddition reaction from 1‐aryl‐1H‐pyrazole‐4‐carbonitriles…”
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Effectiveness of Novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole Derivatives Against Promastigotes and Amastigotes of Leishmania amazonensis by dos Santos Faiões, Viviane, Leon, Leonor L., Canto-Cavalheiro, Marilene M., Torres-Santos, Eduardo C., Bernardino, Alice M. R., Vegi, Percilene F., dos Santos, Maurício S.

“…In this research, a series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles were synthesized and evaluated for in vitro antileishmanial…”
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Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4-carboximidamides derivatives by Santos, Maurício S. dos, Gomes, Adriana O, Bernardino, Alice M. R, Souza, Marcos C. de, Khan, Misbahul A, Brito, Monique A. de, Castro, Helena C, Abreu, Paula A, Rodrigues, Carlos R, Léo, Rosa M. M. de, Leon, Leonor L, Canto-Cavalheiro, Marilene M

“…Chemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search…”
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Synthesis, crystal structure and magnetism of three novel copper(II) complexes with pyrazole-based ligands by Santos, Igor F., Guedes, Guilherme P., Mercante, Luiza A., Bernardino, Alice M.R., Vaz, Maria G.F.

“…► Monomeric copper(II) complex with pyrazole derivative ligands. ► The metal ions display cis and trans conformation depending on the ligand. ► A network of…”
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Synthesis of new 4-(phenylamino)thieno[2,3-b]pyridines and derivatives of the novel benzo[b]thieno[3,2-h][1,6]naphthyridine tetracyclic system by Pinheiro, Luiz C. S., Borgesa, Júlio C., Oliveira, César D., Ferreira, Vitor F., Romeiro, Gilberto A., Marques, Isakelly P., Abreu, Paula A., Frugulheti, Izabel C. P. P., Rodrigues, Carlos R., Albuquerque, Magaly G., Castro, Helena C., Bernardino, and Alice M. R.

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