Search Results - "Bernardin, Francois"
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Highly Multiplexed Targeted Proteomics Acquisition on a TIMS-QTOF
Published in Analytical chemistry (Washington) (26-01-2021)“…Targeted proteomics allows the highly sensitive detection of specific peptides and proteins in complex biological samples. Here, we describe a methodology for…”
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A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells
Published in Molecular cancer (05-10-2018)“…Drug resistance remains an unsolved clinical issue in oncology. Despite promising initial responses obtained with BRAF and MEK kinase inhibitors, resistance to…”
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3
Shedding Light on the Venom Proteomes of the Allergy-Relevant Hymenoptera Polistes dominula (European Paper Wasp) and Vespula spp. (Yellow Jacket)
Published in Toxins (14-05-2020)“…Allergic reactions to stings of Hymenoptera species can have serious or even fatal consequences. If the identification of the culprit insect is possible,…”
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4
Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles
Published in Cancers (14-03-2020)“…Reduced levels of intratumoural oxygen are associated with hypoxia-induced pro-oncogenic events such as invasion, metabolic reprogramming,…”
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Cross‐Talk between miRNAs from the Dlk1‐Dio3 Locus and Histone Methylation to Protect Male Cerebellum from Methyl Donor Deficiency
Published in Molecular nutrition & food research (01-11-2023)“…ScopeDisruption of the one carbon metabolism during development, i.e., following a gestational vitamin B9 and B12 deficiencies, is involved in birth defects…”
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Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia
Published in Molecular cancer (20-05-2010)“…Chronic lymphocytic leukemia (CLL) cells are often affected by genomic aberrations targeting key regulatory genes. Although fludarabine is the standard first…”
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7
Analysis of the dynamic co-expression network of heart regeneration in the zebrafish
Published in Scientific reports (31-05-2016)“…The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far…”
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Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Published in Nature metabolism (2023)“…Cancer cells fuel their increased need for nucleotide supply by upregulating one-carbon (1C) metabolism, including the enzymes methylenetetrahydrofolate…”
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Assessing cellular and circulating miRNA recovery: the impact of the RNA isolation method and the quantity of input material
Published in Scientific reports (20-01-2016)“…MicroRNAs (miRNAs) have emerged as promising cancer biomarkers. However, exploiting their informative potential requires careful optimization of their…”
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10
Quantification of 782 Plasma Peptides by Multiplexed Targeted Proteomics
Published in Journal of proteome research (02-06-2023)“…Blood analysis is one of the foundations of clinical diagnostics. In recent years, the analysis of proteins in blood samples by mass spectrometry has taken a…”
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Proteomic analysis of horse hair extracts provides no evidence for the existence of a hypoallergenic Curly Horse breed
Published in Clinical and translational allergy (01-02-2024)“…Background The American Bashkir Curly Horse is frequently advertised to horse‐allergic riders and claimed to be a so‐called hypoallergenic breed that elicits…”
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Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer
Published in British journal of cancer (28-08-2018)“…Background Distinguishing lung adenocarcinoma (ADC) from squamous cell carcinoma (SCC) has a tremendous therapeutic implication. Sometimes, the commonly used…”
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Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity
Published in Heliyon (30-09-2024)“…Epidemiological studies suggest that metformin reduces the risk of developing several types of cancer, including gliomas, and improves the overall survival in…”
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Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection
Published in Cancers (19-06-2020)“…Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains…”
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Allergen Content of Therapeutic Preparations for Allergen-Specific Immunotherapy of European Paper Wasp Venom Allergy
Published in Toxins (15-04-2022)“…Allergy to (European paper wasp) venom is of particular relevance in Southern Europe, potentially becoming a threat in other regions in the near future, and…”
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Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration
Published in iScience (18-02-2022)“…Glioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative growth of malignant glioma cells into the surrounding brain…”
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Differential effects of antofine N-oxide on solid tumor and leukemia cells
Published in Anti-cancer agents in medicinal chemistry (01-01-2014)“…We have studied the anti-cancer activities of antofine N-oxide isolated and purified from the medicinal plant Cynanchum vincetoxicum. Antofine N-oxide…”
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The actin filament cross‐linker L‐plastin confers resistance to TNF‐α in MCF‐7 breast cancer cells in a phosphorylation‐dependent manner
Published in Journal of cellular and molecular medicine (01-06-2010)“…We used a tumour necrosis factor (TNF)‐α resistant breast adenocarcinoma MCF‐7 cell line to investigate the involvement of the actin cytoskeleton in the…”
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Abstract 3905: Identification of new tumor-specific splice variants in NSCL cancers by whole genome exon arrays
Published in Cancer research (Chicago, Ill.) (15-04-2011)“…Although lung cancer is one of the major causes of cancer death in men and women worldwide, the molecular pathogenesis of this disease remains elusive. The…”
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The actin filament cross-linker L-plastin confers resistance to TNF-[alpha] in MCF-7 breast cancer cells in a phosphorylation-dependent manner
Published in Journal of cellular and molecular medicine (01-06-2010)“…We used a tumour necrosis factor (TNF)-α resistant breast adenocarcinoma MCF-7 cell line to investigate the involvement of the actin cytoskeleton in the…”
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