Search Results - "Bernardazzi, Claudio"

Cell Death and Inflammatory Bowel Diseases : Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium by Nunes, Tiago, de Souza, Heitor S., Bernardazzi, Claudio

“…Cell death mechanisms have been associated with the development of inflammatory bowel diseases in humans and mice. Recent studies suggested that a complex…”
Get full text

The Physiological Function and Potential Role of the Ubiquitous Na+/H+ Exchanger Isoform 8 (NHE8): An Overview Data by Bernardazzi, Claudio, Sheikh, Irshad Ali, Xu, Hua, Ghishan, Fayez K.

“…The Na+/H+ exchanger transporters (NHE) play an important role in various biologic processes including Na+ absorption, intracellular pH homeostasis, cell…”
Get full text

Sulfate-reducing bacteria stimulate gut immune responses and contribute to inflammation in experimental colitis by Figliuolo, Vanessa Ribeiro, dos Santos, Liliane Martins, Abalo, Alessandra, Nanini, Hayandra, Santos, Angela, Brittes, Nilda M., Bernardazzi, Claudio, de Souza, Heitor Siffert Pereira, Vieira, Leda Quercia, Coutinho-Silva, Robson, Coutinho, Claudia Mara Lara Melo

“…The intestinal microbiota is critical for mammalian immune system development and homeostasis. Sulfate-reducing bacteria (SRB) are part of the normal gut…”
Get full text

Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets by Nanini, Hayandra Ferreira, Bernardazzi, Claudio, Castro, Fernando, de Souza, Heitor Siffert Pereira

“…The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of…”
Get full text

The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome by Bernardazzi, Claudio, Castelo-Branco, Morgana Teixeira Lima, Pêgo, Beatriz, Ribeiro, Beatriz Elias, Rosas, Siane Lopes Bittencourt, Santana, Patrícia Teixeira, Machado, João Carlos, Leal, Camille, Thompson, Fabiano, Coutinho-Silva, Robson, de Souza, Heitor Siffert Pereira

“…Given the role of the P2X7 receptor (P2X7R) in inflammatory bowel diseases (IBD), we investigated its role in the development and progression of…”
Get full text

The Role of Innate Immunity Receptors in the Pathogenesis of Inflammatory Bowel Disease by de Souza, Heitor S., Bernardazzi, Claudio, Tolentino, Yolanda Faia M., Elia, Paula Peruzzi

“…Innate immunity constitutes the first line of defense, fundamental for the recognition and the initiation of an inflammatory response against microorganisms…”
Get full text

Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn's disease by Neves, Adriane R, Castelo-Branco, Morgana T L, Figliuolo, Vanessa R, Bernardazzi, Claudio, Buongusto, Fernanda, Yoshimoto, Agnes, Nanini, Hayandra F, Coutinho, Claudia M L M, Carneiro, Antonio José V, Coutinho-Silva, Robson, de Souza, Heitor S P

“…Extracellular nucleotides released in conditions of cell stress alert the immune system from tissue injury or inflammation. We hypothesized that the P2X7…”
Get full text

Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies by Nunes, Tiago, de Souza, Heitor S., Bernardazzi, Claudio

“…Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a…”
Get full text

The Expression of NHE8 in Liver and Its Role in Carbon Tetrachloride–Induced Liver Injury by Tong, Huan, Bernardazzi, Claudio, Curiel, Leslie, Xu, Hua, Ghishan, Fayez K.

“…Sodium-hydrogen exchanger 8 (NHE8) is expressed in array of tissues and has pleiotropic functions beyond simply exchanging sodium and hydrogen across cell…”
Get full text

Neuroimmunomodulation in the Gut: Focus on Inflammatory Bowel Disease by Bernardazzi, Claudio, de Souza, Heitor S., Pêgo, Beatriz

“…Intestinal immunity is finely regulated by several concomitant and overlapping mechanisms, in order to efficiently sense external stimuli and mount an adequate…”
Get full text

Schistosoma mansoni Coinfection Attenuates Murine Toxoplasma gondii -Induced Crohn's-Like Ileitis by Preserving the Epithelial Barrier and Downregulating the Inflammatory Response by Pêgo, Beatriz, Martinusso, Cesonia A, Bernardazzi, Claudio, Ribeiro, Beatriz Elias, de Araujo Cunha, Aline Fernandes, de Souza Mesquita, Jacilene, Nanini, Hayandra F, Machado, Marcelo Pelajo, Castelo-Branco, Morgana T L, Cavalcanti, Marta Guimarães, de Souza, Heitor S P

“…Mice orally infected with develop Crohn's disease (CD)-like enteritis associated with severe mucosal damage and a systemic inflammatory response, resulting in…”
Get full text

Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion by Yoshimoto, Agnes N, Bernardazzi, Claudio, Carneiro, Antonio José V, Elia, Celeste C S, Martinusso, Cesonia A, Ventura, Grasiella M, Castelo-Branco, Morgana T L, de Souza, Heitor S P

“…The Hedgehog (Hh) pathway is involved in embryogenesis and physiologic processes including cell survival and proliferation. We used the HT-29 and other human…”
Get full text

Su1147: NHE8 IMPAIRS GOBLET CELL DIFFERENATIATION/MATURATION VIA ALTERED DDL4 EXPRESSION IN THE COLON by Bernardazzi, Claudio, Ghishan, Fayez K., Xu, Hua

Get full text

P2X7 receptor promotes intestinal inflammation in chemically induced colitis and triggers death of mucosal regulatory T cells by Figliuolo, Vanessa R., Savio, Luiz Eduardo Baggio, Safya, Hanaa, Nanini, Hayandra, Bernardazzi, Cláudio, Abalo, Alessandra, de Souza, Heitor S.P., Kanellopoulos, Jean, Bobé, Pierre, Coutinho, Cláudia M.L.M., Coutinho-Silva, Robson

“…P2X7 receptor activation contributes to inflammation development in different pathologies. We previously reported that the P2X7 receptor is over-expressed in…”
Get full text

Su1118 THE ROLE OF BUTYRATE ON NHE8-DEFICIENT GOBLET CELLS: AN IN VIVO AND IN VITRO STUDY by Bernardazzi, Claudio, Xu, Hua, Ghishan, Fayez K.

Get full text

Protective effect of adipose tissue–derived mesenchymal stromal cells in an experimental model of high-risk colonic anastomosis by Alvarenga, Valter, Silva, Pedro Teixeira da, Bonfá, Natália Deoclécio, Pêgo, Beatriz, Nanini, Hayandra, Bernardazzi, Cláudio, Madi, Kalil, Baetas da Cruz, Wagner, Castelo-Branco, Morgana Teixeira, de Souza, Heitor Siffert Pereira, Schanaider, Alberto

“…Dehiscence of intestinal anastomosis results in high morbidity and mortality. The aim of this study was to investigate the effects of locally administered…”
Get full text

Sa1129 – Effects of Butyrate Supplementation on Nhe8Ko Mice by Bernardazzi, Claudio, Ghishan, Fayez K., Xu, Hua

Get full text

Diet and microbiota in inflammatory bowel disease: The gut in disharmony by Rapozo, Davy C M, Bernardazzi, Claudio, de Souza, Heitor Siffert Pereira

“…Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and…”
Get full text

Tu1214 INHIBITION OF NHE3 MEDIATES INCREASED PROLIFERATION AND MIGRATION OF COLONIC EPITHELIAL CELLS by Saha, Tultul, Gurney, Michael A., Bernardazzi, Claudio, Midura-Kiela, Monica, Ghishan, Fayez K., Kiela, Pawel R.

Get full text

Sa1130 – Loss of Nhe8 Impairs Goblet Cell Differentiation/Maturation in the Colon by Xu, Hua, Bernardazzi, Claudio, Li, Jing, Ghishan, Fayez K.

Get full text