Search Results - "Bernard Haendler"

Recent Advances in Prostate Cancer Treatment and Drug Discovery by Nevedomskaya, Ekaterina, Baumgart, Simon J, Haendler, Bernard

“…Novel drugs, drug sequences and combinations have improved the outcome of prostate cancer in recent years. The latest approvals include abiraterone acetate,…”
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From Omics to Multi-Omics Approaches for In-Depth Analysis of the Molecular Mechanisms of Prostate Cancer by Nevedomskaya, Ekaterina, Haendler, Bernard

“…Cancer arises following alterations at different cellular levels, including genetic and epigenetic modifications, transcription and translation dysregulation,…”
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Targeting DNA Damage Response in Prostate and Breast Cancer by Wengner, Antje M, Scholz, Arne, Haendler, Bernard

“…Steroid hormone signaling induces vast gene expression programs which necessitate the local formation of transcription factories at regulatory regions and…”
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Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4 by Zanconato, Francesca, Battilana, Giusy, Forcato, Mattia, Filippi, Letizia, Azzolin, Luca, Manfrin, Andrea, Quaranta, Erika, Di Biagio, Daniele, Sigismondo, Gianluca, Guzzardo, Vincenza, Lejeune, Pascale, Haendler, Bernard, Krijgsveld, Jeroen, Fassan, Matteo, Bicciato, Silvio, Cordenonsi, Michelangelo, Piccolo, Stefano

“…Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the…”
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Addressing the Reciprocal Crosstalk between the AR and the PI3K/AKT/mTOR Signaling Pathways for Prostate Cancer Treatment by Raith, Fabio, O'Donovan, Daniel H, Lemos, Clara, Politz, Oliver, Haendler, Bernard

“…The reduction in androgen synthesis and the blockade of the androgen receptor (AR) function by chemical castration and AR signaling inhibitors represent the…”
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Preclinical Anticipation of On- and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review by Dziubańska-Kusibab, Paulina J, Nevedomskaya, Ekaterina, Haendler, Bernard

“…The advent of targeted therapies has led to tremendous improvements in treatment options and their outcomes in the field of oncology. Yet, many cancers…”
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Exploiting Epigenetic Alterations in Prostate Cancer by Baumgart, Simon J, Haendler, Bernard

“…Prostate cancer affects an increasing number of men worldwide and is a leading cause of cancer-associated deaths. Beside genetic mutations, many epigenetic…”
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Dysregulated Transcriptional Control in Prostate Cancer by Baumgart, Simon J, Nevedomskaya, Ekaterina, Haendler, Bernard

“…Recent advances in whole-genome and transcriptome sequencing of prostate cancer at different stages indicate that a large number of mutations found in tumors…”
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Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF by Bennett, James, Fedorov, Oleg, Tallant, Cynthia, Monteiro, Octovia, Meier, Julia, Gamble, Vicky, Savitsky, Pavel, Nunez-Alonso, Graciela A, Haendler, Bernard, Rogers, Catherine, Brennan, Paul E, Müller, Susanne, Knapp, Stefan

“…TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in diverse tumors, and high expression levels have been linked to…”
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Darolutamide antagonizes androgen signaling by blocking enhancer and super‐enhancer activation by Baumgart, Simon J., Nevedomskaya, Ekaterina, Lesche, Ralf, Newman, Richard, Mumberg, Dominik, Haendler, Bernard

“…Prostate cancer (PCa) is one of the most frequent tumor types in the male Western population. Early‐stage PCa and late‐stage PCa are dependent on androgen…”
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Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents by Klingbeil, Olaf, Lesche, Ralf, Gelato, Kathy A, Haendler, Bernard, Lejeune, Pascale

“…Non-small cell lung cancer (NSCLC) has the highest incidence of cancer-related death worldwide and a high medical need for more effective therapies…”
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Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs by Gelato, Kathy A, Shaikhibrahim, Zaki, Ocker, Matthias, Haendler, Bernard

“…Histone deacetylases (HDACs) and DNA methyltransferases (DNMTs) were the first epigenetic targets to be successfully addressed for cancer treatment, but more…”
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Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma by Bernasconi, Elena, Gaudio, Eugenio, Lejeune, Pascale, Tarantelli, Chiara, Cascione, Luciano, Kwee, Ivo, Spriano, Filippo, Rinaldi, Andrea, Mensah, Afua A., Chung, Elaine, Stathis, Anastasios, Siegel, Stephan, Schmees, Norbert, Ocker, Matthias, Zucca, Emanuele, Haendler, Bernard, Bertoni, Francesco

“…Summary The epigenome is often deregulated in cancer and treatment with inhibitors of bromodomain and extra‐terminal proteins, the readers of epigenetic…”
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Enhanced Antitumor Efficacy of Radium-223 and Enzalutamide in the Intratibial LNCaP Prostate Cancer Model by Suominen, Mari I, Knuuttila, Matias, Schatz, Christoph A, Schlicker, Andreas, Vääräniemi, Jukka, Sjöholm, Birgitta, Alhoniemi, Esa, Haendler, Bernard, Mumberg, Dominik, Käkönen, Sanna-Maria, Scholz, Arne

“…Radium-223 dichloride and enzalutamide are indicated for metastatic castration-resistant prostate cancer and their combination is currently being investigated…”
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Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis by Sugawara, Tatsuo, Nevedomskaya, Ekaterina, Heller, Simon, Böhme, Annika, Lesche, Ralf, Ahsen, Oliver, Grünewald, Sylvia, Nguyen, Holly M., Corey, Eva, Baumgart, Simon J., Georgi, Victoria, Pütter, Vera, Fernández‐Montalván, Amaury, Vasta, James D., Robers, Matthew B., Politz, Oliver, Mumberg, Dominik, Haendler, Bernard

“…Prostate cancer is a frequent malignancy in older men and has a very high 5‐year survival rate if diagnosed early. The prognosis is much less promising if the…”
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The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event? by Douard, Véronique, Brunet, Frédéric, Boussau, Bastien, Ahrens-Fath, Isabelle, Vlaeminck-Guillem, Virginie, Haendler, Bernard, Laudet, Vincent, Guiguen, Yann

“…Based on the observation of an increased number of paralogous genes in teleost fishes compared with other vertebrates and on the conserved synteny between…”
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The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models by Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard

“…Purpose 5′ adenosine monophosphate-activated kinase (AMPK) is an essential regulator of cellular energy homeostasis and has been associated with different…”
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BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients by Sugawara, Tatsuo, Lejeune, Pascale, Köhr, Silke, Neuhaus, Roland, Faus, Hortensia, Gelato, Kathy A, Busemann, Matthias, Cleve, Arwed, Lücking, Ulrich, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Jung, Klaus, Stephan, Carsten, Haendler, Bernard

“…Androgen receptor (AR) mutations arise in patients developing resistance to hormone deprivation therapies. Here we describe BAY 1024767, a thiohydantoin…”
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The ubiquitin-specific protease USP10 modulates androgen receptor function by Faus, Hortensia, Meyer, Hellmuth-Alexander, Huber, Martina, Bahr, Inke, Haendler, Bernard

“…The role of the ubiquitin/proteasome system in degrading nuclear hormone receptors and regulating their transcriptional function has emerged in the last few…”
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Stimulation of N-Terminal Truncated Isoform of Androgen Receptor Stabilizes Human Ether-á-go-go-Related Gene-Encoded Potassium Channel Protein via Activation of Extracellular Signal Regulated Kinase 1/2 by Wu, Zhi-Yuan, Chen, Kun, Haendler, Bernard, McDonald, Thomas V, Bian, Jin-Song

“…Proarrhythmic drugs induce long QT syndrome more frequently in women than men. The present study was designed to determine whether androgens regulate the…”
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