Search Results - "Bernard, Leroy"

TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade by Leroy, Bernard, Anderson, Martha, Soussi, Thierry

“…ABSTRACT More than 50% of human tumors carry TP53 gene mutations and in consequence more than 45,000 somatic and germline mutations have been gathered in the…”
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Analysis of TP53 Mutation Status in Human Cancer Cell Lines: A Reassessment by Leroy, Bernard, Girard, Luc, Hollestelle, Antoinette, Minna, John D., Gazdar, Adi F., Soussi, Thierry

“…ABSTRACT Tumor‐derived cell lines play an important role in the investigation of tumor biology and genetics. Across a wide array of studies, they have been…”
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Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries by Carbonnier, Vincent, Leroy, Bernard, Rosenberg, Shai, Soussi, Thierry

“…The diagnosis of somatic and germline TP53 mutations in human tumors or in individuals prone to various types of cancer has now reached the clinic. To increase…”
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Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors by Edlund, Karolina, Larsson, Ola, Ameur, Adam, Bunikis, Ignas, Gyllensten, Ulf, Leroy, Bernard, Sundström, Magnus, Micke, Patrick, Botling, Johan, Soussi, Thierry

“…Cancer mutation databases are expected to play central roles in personalized medicine by providing targets for drug development and biomarkers to tailor…”
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Incidence of adverse events in antipsychotic-naïve children and adolescents treated with antipsychotic drugs: a French multicentre naturalistic study protocol (ETAPE) by Menard, Marie-Line, Thümmler, Susanne, Giannitelli, Marianna, Olliac, Bertrand, Bonnot, Olivier, Cohen, David, Askenazy, Florence, Michel, Boublil, Agnès, Castaings, Jean, Chambry, Dorothée, Charvet, Mona, Cseterky, Eric, Fontas, Pierre, Fourneret, Ludovic, Gicquel, Bernard, Kabuth, Bernard, Leroy, Fanny, Maria, Pamela, Moceri, Jean-Philippe, Raynaud, Jean-François, Roche, Thierry, Rochet

“…IntroductionIn France, over recent years, the prescription rate of antipsychotic (AP) remained stable in children and adolescents. Prescription of…”
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Mild and chemoselective catalytic deprotection of ketals and acetals using cerium(IV) ammonium nitrate by Ates, Ali, Gautier, Arnaud, Leroy, Bernard, Plancher, Jean-Marc, Quesnel, Yannick, Vanherck, Jean-Christophe, Markó, István E

“…Cerium(IV) ammonium nitrate (CAN) is a powerful, though mild, reagent for the efficient and selective removal of a range of ketals and acetals. This novel…”
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Connective Synthesis of Polysubstituted Tetrahydropyrans by a Novel and Stereocontrolled Metallo-ene/Intramolecular Sakurai Cyclization Sequence by Leroy, Bernard, Markó, István E

“…A novel methodology based upon the allylmetalation step followed by an Intramolecular Sakurai Cyclization (IMSC) provides an efficient access to a variety of…”
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Rapid and Versatile Synthesis of Functionalized Polyhydroxylated Fragments by Leroy, Bernard, Markó, István E

“…The condensation between a functionalized allylstannane and α-alkoxyaldehydes allows rapid access to complex and selectively protected trihydroxylated…”
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Cerium(IV)-Catalyzed Deprotection of Acetals and Ketals under Mildly Basic Conditions by Markó, István E., Ates, Ali, Gautier, Arnaud, Leroy, Bernard, Plancher, Jean-Marc, Quesnel, Yannick, Vanherck, Jean-Christophe

“…Smooth and quantitative deprotection of a wide range of acetals and ketals [Eq. (a); R, R1=alkyl, aryl, H] under neutral to mildly basic conditions was…”
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High prevalence of cancer‐associated TP53 variants in the gnomAD database: A word of caution concerning the use of variant filtering by Soussi, Thierry, Leroy, Bernard, Devir, Michal, Rosenberg, Shai

“…The 1,000 genome project, the Exome Aggregation Consortium (ExAC) or the Genome Aggregation database (gnomAD) datasets, were developed to provide large‐scale…”
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Preparation and applications of a novel bis(tributylstannyl)cyclopropane: a synthetic equivalent of a cyclopropane-1,2-dianion by Heureux, Nicolas, Marchant, Mélanie, Maulide, Nuno, Berthon-Gelloz, Guillaume, Hermans, Christophe, Hermant, Sébastien, Kiss, Eleonóra, Leroy, Bernard, Wasnaire, Pierre, Markó, István E.

“…[Display omitted] The preparation of the novel trans-1,2-bis-stannylcyclopropane 4 is described. Its applications in Kosugi–Migita–Stille cross-coupling and in…”
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TP53_PROF: a machine learning model to predict impact of missense mutations in TP53 by Ben-Cohen, Gil, Doffe, Flora, Devir, Michal, Leroy, Bernard, Soussi, Thierry, Rosenberg, Shai

“…Abstract Correctly identifying the true driver mutations in a patient’s tumor is a major challenge in precision oncology. Most efforts address frequent…”
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Efficient and connective synthesis of substituted butyrolactones and exo-methylene butyrolactones by Leroy, Bernard, Dumeunier, Raphaël, Markó, István E

“…A variety of α-(trimethylsilylmethyl)-substituted butyrolactones are readily accessed by a novel tandem ene-reaction/oxidative desilylation of a range of…”
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The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis by Leroy, Bernard, Fournier, Jean Louis, Ishioka, Chikashi, Monti, Paola, Inga, Alberto, Fronza, Gilberto, Soussi, Thierry

“…A novel resource centre for TP53 mutations and mutants has been developed (http://p53.fr). TP53 gene dysfunction can be found in the majority of human cancer…”
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Transcutaneous neurostimulation parameters for neuropathic radicular pain: Results from a two period crossover randomized trial by Ducoulombier, Vincent, Challi, Hassane, Petit, Pavlos, Leroy, Bernard, Versavel, Adeline, Luraschi, Hélène, Chiquet, Romain, Zenati, Kheira, Budzik, Jean-François, Desrousseaux, Jean-François, Khenioui, Hichem, Bera-Louville, Anne, Houvenagel, Eric, Norberciak, Laurène, Pascart, Tristan

“…•Transcutaneous neurostimulation is commonly used to treat chronic neuropathic radicular pain.•Two types of current are usually used: the c-TENS and the…”
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Artificial Recharge of the Shallow Alluvial Aquifer as an Adaptation Strategy in the Garonne Valley, France by Asmael, Nazeer, Dupuy, Alain, Leroy, Bernard

“…The Garonne River is the primary river in the southwest part of France. The Quaternary alluvial aquifer along this River may represent a substantial water…”
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Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene by Doffe, Flora, Carbonnier, Vincent, Tissier, Manon, Leroy, Bernard, Martins, Isabelle, Mattsson, Johanna S. M., Micke, Patrick, Pavlova, Sarka, Pospisilova, Sarka, Smardova, Jana, Joerger, Andreas C., Wiman, Klas G., Kroemer, Guido, Soussi, Thierry

“…Infrequent and rare genetic variants in the human population vastly outnumber common ones. Although they may contribute significantly to the genetic basis of a…”
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Seshat: A Web service for accurate annotation, validation, and analysis of TP53 variants generated by conventional and next‐generation sequencing by Tikkanen, Tuomas, Leroy, Bernard, Fournier, Jean Louis, Risques, Rosa Ana, Malcikova, Jitka, Soussi, Thierry

“…Accurate annotation of genomic variants in human diseases is essential to allow personalized medicine. Assessment of somatic and germline TP53 alterations has…”
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The Broad Spectrum of TP53 Mutations in CLL: Evidence of Multiclonality and Novel Mutation Hotspots by Lazarian, Grégory, Leroy, Bernard, Theves, Floriane, Hormi, Myriam, Letestu, Rémi, Eclache, Virginie, Tueur, Giulia, Ameur, Adam, Bidet, Audrey, Cornillet-Lefebvre, Pascale, Davi, Frédéric, Delabesse, Eric, Estienne, Marie-Hélène, Etancelin, Pascaline, Kosmider, Olivier, Laibe, Sophy, Muller, Marc, Nadal, Nathalie, Naguib, Dina, Pastoret, Cédric, Poulain, Stéphanie, Sujobert, Pierre, Veronese, Lauren, Imache, Samia, Lefebvre, Valérie, Cymbalista, Florence, Baran-Marszak, Fanny, Soussi, Thierry

“…TP53 aberrations are a major predictive factor of resistance to chemoimmunotherapy in chronic lymphocytic leukemia (CLL), and an assessment of them before each…”
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Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice by Leroy, Bernard, Ballinger, Mandy L, Baran-Marszak, Fanny, Bond, Gareth L, Braithwaite, Antony, Concin, Nicole, Donehower, Lawrence A, El-Deiry, Wafik S, Fenaux, Pierre, Gaidano, Gianluca, Langerød, Anita, Hellstrom-Lindberg, Eva, Iggo, Richard, Lehmann-Che, Jacqueline, Mai, Phuong L, Malkin, David, Moll, Ute M, Myers, Jeffrey N, Nichols, Kim E, Pospisilova, Sarka, Ashton-Prolla, Patricia, Rossi, Davide, Savage, Sharon A, Strong, Louise C, Tonin, Patricia N, Zeillinger, Robert, Zenz, Thorsten, Fraumeni, Jr, Joseph F, Taschner, Peter E M, Hainaut, Pierre, Soussi, Thierry

“…Accurate assessment of gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li-Fraumeni Syndrome (LFS) has important…”
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