Search Results - "Bernard, G. R."

Long-Term Cognitive Impairment after Critical Illness by Pandharipande, P.P, Girard, T.D, Jackson, J.C, Morandi, A, Thompson, J.L, Pun, B.T, Brummel, N.E, Hughes, C.G, Vasilevskis, E.E, Shintani, A.K, Moons, K.G, Geevarghese, S.K, Canonico, A, Hopkins, R.O, Bernard, G.R, Dittus, R.S, Ely, E.W

“…In this study, patients treated in ICUs were at high risk for new cognitive impairment during 12 months of follow-up, with 24% of patients having deficits…”
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Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project by Pulley, J M, Denny, J C, Peterson, J F, Bernard, G R, Vnencak-Jones, C L, Ramirez, A H, Delaney, J T, Bowton, E, Brothers, K, Johnson, K, Crawford, D C, Schildcrout, J, Masys, D R, Dilks, H H, Wilke, R A, Clayton, E W, Shultz, E, Laposata, M, McPherson, J, Jirjis, J N, Roden, D M

“…The promise of “personalized medicine” guided by an understanding of each individual's genome has been fostered by increasingly powerful and economical methods…”
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Development of a Large-Scale De-Identified DNA Biobank to Enable Personalized Medicine by Roden, DM, Pulley, JM, Basford, MA, Bernard, GR, Clayton, EW, Balser, JR, Masys, DR

“…Our objective was to develop a DNA biobank linked to phenotypic data derived from an electronic medical record (EMR) system. An “opt‐out” model was implemented…”
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Development of a Large-Scale De-Identified DNA Biobank to Enable Personalized Medicine by Roden, DM, Pulley, JM, Basford, MA, Bernard, GR, Clayton, EW, Balser, JR, Masys, DR

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A Randomized Trial of the Effects of Nebulized Albuterol on Pulmonary Edema in Brain‐Dead Organ Donors by Ware, L. B., Landeck, M., Koyama, T., Zhao, Z., Singer, J., Kern, R., Neidlinger, N., Nguyen, J., Johnson, E., Janz, D. R., Bernard, G. R., Lee, J. W., Matthay, M. A.

“…Donor lung utilization rates are persistently low primarily due to donor lung dysfunction. We hypothesized that a treatment that enhances the resolution of…”
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Treating Patients with Severe Sepsis by Wheeler, Arthur P, Bernard, Gordon R

“…Sepsis is an infection-induced syndrome defined as the presence of two or more of the following features of systemic inflammation: fever or hypothermia,…”
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Multiple Organ Dysfunction Score: A reliable descriptor of a complex clinical outcome by Marshall, John C, Cook, Deborah J, Christou, Nicolas V, Bernard, Gordon R, Sprung, Charles L, Sibbald, William J

“…OBJECTIVETo develop an objective scale to measure the severity of the multiple organ dysfunction syndrome as an outcome in critical illness. DESIGNSystematic…”
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The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination by Bernard, G R, Artigas, A, Brigham, K L, Carlet, J, Falke, K, Hudson, L, Lamy, M, Legall, J R, Morris, A, Spragg, R

“…The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a…”
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Report of the American-European consensus conference on ARDS : definitions, mechanisms, relevant outcomes and clinical trial coordination by BERNARD, G. R, ARTIGAS, A, BRIGHAM, K. L, CARLET, J, FALKE, K, HUDSON, L, LAMY, M, LEGALL, J. R, MORRIS, A, SPRAGG, R

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The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling by ARTIGAS, A, BERNARD, G. R, SPRAGG, R, SUTER, P. M, CARLET, J, DREYFUSS, D, GATTINONI, L, HUDSON, L, LAMY, M, MARINI, J. J, MATTHAY, M. A, PINSKY, M. R

“…The acute respiratory distress syndrome (ARDS) continues as a contributor to the morbidity and mortality of patients in intensive care units throughout the…”
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Airway and lung in sepsis by Martin, G S, Bernard, G R

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Drotrecogin Alfa (Activated) Treatment of Older Patients with Severe Sepsis by Ely, E. Wesley, Angus, Derek C., Williams, Mark D., Bates, Becky, Qualy, Rebecca, Bernard, Gordon R.

“…The incidence of severe sepsis increases dramatically with advanced age, with a mortality rate that approaches 50%. The main purpose of this investigation was…”
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A simple multiple system organ failure scoring system predicts mortality of patients who have sepsis syndrome by Hebert, P C, Drummond, A J, Singer, J, Bernard, G R, Russell, J A

“…A simple multiple system organ failure (MSOF) score may predict mortality of patients who have sepsis syndrome. Using an MSOF scoring system, we prospectively…”
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An Imbalance between the Excretion of Thromboxane and Prostacyclin Metabolites in Pulmonary Hypertension by Christman, Brian W, McPherson, Charles D, Newman, John H, King, Gayle A, Bernard, Gordon R, Groves, Bertron M, Loyd, James E

“…THE pathogenesis of pulmonary hypertension is incompletely understood. The histologic features of the small pulmonary arteries of patients with this disease…”
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Quantification of organ dysfunction: Seeking standardization by Bernard, Gordon R

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Effect of bronchodilators on lung mechanics in the acute respiratory distress syndrome (ARDS) by Wright, P E, Carmichael, L C, Bernard, G R

“…The acute respiratory distress syndrome (ARDS) is a disorder of diffuse lung injury secondary to a wide variety of clinical insults (eg, sepsis) and is…”
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Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis by Man, M, Close, S L, Shaw, A D, Bernard, G R, Douglas, I S, Kaner, R J, Payen, D, Vincent, J-L, Fossceco, S, Janes, J M, Leishman, A G, O'Brien, L, Williams, M D, Garcia, J G N

“…Management of severe sepsis, an acute illness with high morbidity and mortality, suffers from the lack of effective biomarkers and largely empirical…”
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Delirium in Mechanically Ventilated Patients: Validity and Reliability of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) by Ely, E. Wesley, Inouye, Sharon K, Bernard, Gordon R, Gordon, Sharon, Francis, Joseph, May, Lisa, Truman, Brenda, Speroff, Theodore, Gautam, Shiva, Margolin, Richard, Hart, Robert P, Dittus, Robert

“…CONTEXT Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically…”
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Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) by Ely, E Wesley, Margolin, Richard, Francis, Joseph, May, Lisa, Truman, Brenda, Dittus, Robert, Speroff, Theodore, Gautam, Shiva, Bernard, Gordon R, Inouye, Sharon K

“…OBJECTIVETo develop and validate an instrument for use in the intensive care unit to accurately diagnose delirium in critically ill patients who are often…”
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The impact of delirium in the intensive care unit on hospital length of stay by ELY, E. W, GAUTAM, S, MARGOLIN, R, FRANCIS, J, MAY, L, SPEROFF, T, TRUMAN, B, DITTUS, R, BERNARD, G. R, INOUYE, S. K

“…To determine the relationship between delirium in the intensive care unit (ICU) and outcomes including length of stay in the hospital. A prospective cohort…”
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