Search Results - "Bernad, A"

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis by Estrada, J C, Albo, C, Benguría, A, Dopazo, A, López-Romero, P, Carrera-Quintanar, L, Roche, E, Clemente, E P, Enríquez, J A, Bernad, A, Samper, E

“…Expansion of human stem cells before cell therapy is typically performed at 20% O 2 . Growth in these pro-oxidative conditions can lead to oxidative stress and…”
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miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells by Tomé, M, López-Romero, P, Albo, C, Sepúlveda, J C, Fernández-Gutiérrez, B, Dopazo, A, Bernad, A, González, M A

“…In spite of the extensive potential of human mesenchymal stem cells (hMSCs) in cell therapy, little is known about the molecular mechanisms that regulate their…”
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Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy by Estrada, J C, Torres, Y, Benguría, A, Dopazo, A, Roche, E, Carrera-Quintanar, L, Pérez, R A, Enríquez, J A, Torres, R, Ramírez, J C, Samper, E, Bernad, A

“…In most clinical trials, human mesenchymal stem cells (hMSCs) are expanded in vitro before implantation. The genetic stability of human stem cells is critical…”
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A feasibility study of a liquid shutdown system for a single-fluid molten salt fast reactor by Fradera, J., Alberto, P., Moya, G., Bernad, A., Fernández, A.

“…•A feasibility study on a liquid shutdown system concept for molten salt reactors is presented•A Liquid metal discharged by gravity is used as a neutron…”
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Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells by Garcia, S., Martín, M.C., de la Fuente, R., Cigudosa, J.C., Garcia-Castro, J., Bernad, A.

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Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma by Orgaz, J L, Ladhani, O, Hoek, K S, Fernández-Barral, A, Mihic, D, Aguilera, O, Seftor, E A, Bernad, A, Rodríguez-Peralto, J L, Hendrix, M J C, Volpert, O V, Jiménez, B

“…Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein that displays broad anti-tumor activity based on dual targeting of the…”
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miR-300 mediates Bmi1 function and regulates differentiation in primitive cardiac progenitors by Cruz, F M, Tomé, M, Bernal, J A, Bernad, A

“…B lymphoma Mo-MLV insertion region 1 (Bmi1) is a polycomb-family transcriptional factor critical for self-renewal in many adult stem cells and human neoplasia…”
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Comparative phenotypic and molecular characterization of porcine mesenchymal stem cells from different sources for translational studies in a large animal model by Casado, Javier G., Gomez-Mauricio, G., Alvarez, V., Mijares, J., Tarazona, R., Bernad, A., Sanchez-Margallo, F.M.

“…Mesenchymal stem cells have demonstrated their potentiality for therapeutic use in treating diseases or repairing damaged tissues. However, in some cases, the…”
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Unraveling the Diagnosis of Kiwifruit Allergy: Usefulness of Current Diagnostic Tests by D’Amelio, CM, Bernad, A, García-Figueroa, BE, Garrido-Fernández, S, Azofra, J, Beristain, A, Bueno-Díaz, C, Garrido-Arandia, M, Gastaminza, G, Ferrer, M, Díaz Perales, A, Villalba, M, Goikoetxea, MJ

“…Objectives: To determine the usefulness of the in vitro and in vivo methods used in the diagnosis of kiwifruit allergy and to specifically assess the impact of…”
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Induction of tolerance to different types of fish through desensitization with hake by D'Amelio, C., Gastaminza, G., Vega, O., Bernad, A., Madamba, R. C., Martínez‐Aranguren, R., Ferrer, M., Goikoetxea, M. J.

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In vitro expansion of human cardiac progenitor cells: Exploring ‘omics tools for characterization of cell-based allogeneic products by Gomes-Alves, P, Serra, M, Brito, C, Ricardo, C.P, Cunha, R, Sousa, M.F, Sanchez, B, Bernad, A, Carrondo, M.J.T, Rodriguez-Borlado, L, Alves, P.M

“…Abstract Cardiac stem/progenitor cells (hCPC) have been shown to be capable to regenerate contractile myocardium. However, due to their relative low abundance…”
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Constituent materials micro-damage modeling in predicting progressive failure of braided fiber composites by Nobeen, Nadeesh Singh, Zhong, Yucheng, Francis, Bernad A.P., Ji, Xianbai, Chia, Elvin S.M., Joshi, Sunil C., Chen, Zhong

“…Braided textile composite exhibits an efficient mechanism to distribute loads throughout its structure and have excellent impact resistant properties. Despite…”
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Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA x anti-CD3 diabodies from lentivirally transduced human lymphocytes by Compte, M, Blanco, B, Serrano, F, Cuesta, A M, Sanz, L, Bernad, A, Holliger, P, Alvarez-Vallina, L

“…Infiltrating T lymphocytes are found in many malignancies, but they appear to be mostly anergic and do not attack the tumor, presumably because of defective…”
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Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA × anti-CD3 diabodies from lentivirally transduced human lymphocytes by Compte, M, Blanco, B, Serrano, F, Cuesta, Á M, Sanz, L, Bernad, A, Holliger, P, Álvarez-Vallina, L

“…Infiltrating T lymphocytes are found in many malignancies, but they appear to be mostly anergic and do not attack the tumor, presumably because of defective…”
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Highly efficient DNA synthesis by the phage φ29 DNA polymerase: symmetrical mode of DNA replication by BLANCO, L, BERNAD, A, LAZARO, J. M, MARTIN, G, GARMENDIA, C, SALAS, M

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A role for chemokine receptor transactivation in growth factor signaling by Mira, Emilia, Lacalle, Rosa Ana, González, Manuel A, Gómez-Moutón, Concepción, Abad, José Luis, Bernad, Antonio, Martínez-A, Carlos, Mañes, Santos

“…Complex cell responses require the integration of signals delivered through different pathways. We show that insulin‐like growth factor (IGF)‐I induces…”
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Highly efficient DNA synthesis by the phage phi 29 DNA polymerase. Symmetrical mode of DNA replication by Blanco, L, Bernad, A, Lázaro, J M, Martín, G, Garmendia, C, Salas, M

“…The results presented in this paper indicate that the phi 29 DNA polymerase is the only enzyme required for efficient synthesis of full length phi 29 DNA with…”
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Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation by Guinea, Bárbara, Ligos, José Manuel, Laín de Lera, Teresa, Martín-Caballero, Juan, Flores, Juana, Gonzalez de la Peña, Manuel, García-Castro, Javier, Bernad, Antonio

“…PKL12/STK16 protein is the first identified mammalian member of a ser/thr kinase subfamily that is conserved across several kingdoms, with a broad expression…”
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Microstructural characterisation of rotary friction welded AA6082 and Ti-6Al-4V dissimilar joints by Meisnar, M., Baker, S., Bennett, J.M., Bernad, A., Mostafa, A., Resch, S., Fernandes, N., Norman, A.

“…The aim of this work was to investigate the weld interface and microstructure of a rotary friction welded (RFW) Ti-6Al-4V to AA6082 joint for the purpose of…”
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Initiation of phi 29 DNA replication occurs at the second 3' nucleotide of the linear template: a sliding-back mechanism for protein-primed DNA replication by Méndez, J, Blanco, L, Esteban, J A, Bernad, A, Salas, M

“…Bacteriophage phi 29 DNA replication is initiated when a molecule of dAMP is covalently linked to a free molecule of the terminal protein, in a reaction…”
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