Search Results - "Bernabéu, Carmelo"

Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers by Sierra-Filardi, Elena, Puig-Kröger, Amaya, Blanco, Francisco J., Nieto, Concha, Bragado, Rafael, Palomero, M. Isabel, Bernabéu, Carmelo, Vega, Miguel A., Corbí, Angel L.

“…M-CSF favors the generation of folate receptor β–positive (FRβ+), IL-10–producing, immunosuppressive, M2-polarized macrophages [M2 (M-CSF)], whereas GM-CSF…”
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Pregnancy-Induced High Plasma Levels of Soluble Endoglin in Mice Lead to Preeclampsia Symptoms and Placental Abnormalities by Pérez-Roque, Lucía, Núñez-Gómez, Elena, Rodríguez-Barbero, Alicia, Bernabéu, Carmelo, López-Novoa, José M, Pericacho, Miguel

“…Preeclampsia is a pregnancy-specific disease of high prevalence characterized by the onset of hypertension, among other maternal or fetal signs. Its…”
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Co-injection of mesenchymal stem cells with endothelial progenitor cells accelerates muscle recovery in hind limb ischemia through an endoglin-dependent mechanism by Rossi, Elisa, Smadja, David, Goyard, Celine, Cras, Audrey, Dizier, Blandine, Bacha, Nour, Lokajczyk, Anna, Guerin, Coralie L, Gendron, Nicolas, Planquette, Benjamin, Mignon, Virginie, Bernabéu, Carmelo, Sanchez, Olivier, Smadja, David M

“…Endothelial colony-forming cells (ECFCs) are progenitor cells committed to endothelial lineages and have robust vasculogenic properties. Mesenchymal stem cells…”
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The Splicing Factor SRSF1 as a Marker for Endothelial Senescence by Blanco, Francisco Javier, Bernabéu, Carmelo

“…Aging is the major risk factor per se for the development of cardiovascular diseases. The senescence of the endothelial cells (ECs) that line the lumen of…”
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The role of endoglin in post-ischemic revascularization by Núñez-Gómez, Elena, Pericacho, Miguel, Ollauri-Ibáñez, Claudia, Bernabéu, Carmelo, López-Novoa, José M.

“…Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by reorganizing preexisting capillaries…”
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Propranolol as antiangiogenic candidate for the therapy of hereditary haemorrhagic telangiectasia by Albiñana, Virginia, Recio-Poveda, Lucía, Zarrabeitia, Roberto, Bernabéu, Carmelo, Botella, Luisa María

“…The β-blocker propranolol, originally designed for cardiological indications (angina, cardiac arrhythmias and high blood pressure), is nowadays, considered the…”
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Bazedoxifene, a new orphan drug for the treatment of bleeding in hereditary haemorrhagic telangiectasia by Zarrabeitia, Roberto, Ojeda-Fernandez, Luisa, Recio, Lucia, Bernabéu, Carmelo, Parra, Jose A, Albiñana, Virginia, Botella, Luisa M

“…Hereditary haemorrhagic telangiectasia (HHT), or Rendu-Osler-Weber syndrome, is a dominant genetic vascular disorder. In HHT, blood vessels are weak and prone…”
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L- and S-endoglin differentially modulate TGFβ1 signaling mediated by ALK1 and ALK5 in L₆E₉ myoblasts by Velasco, Soraya, Alvarez-Muñoz, Patricia, Pericacho, Miguel, Dijke, Peter ten, Bernabéu, Carmelo, López-Novoa, José M, Rodríguez-Barbero, Alicia

“…TGFβ regulates cellular processes by binding to type I and type II TGFβ receptors (TβRI and TβRII, respectively). In addition to these signaling receptors,…”
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Vascular Injury Triggers Krüppel-Like Factor 6 Mobilization and Cooperation With Specificity Protein 1 to Promote Endothelial Activation Through Upregulation of the Activin Receptor-Like Kinase 1 Gene by Garrido-Martín, Eva M, Blanco, Francisco J, Roquè, Mercé, Novensà, Laura, Tarocchi, Mirko, Lang, Ursula E, Suzuki, Toru, Friedman, Scott L, Botella, Luisa M, Bernabéu, Carmelo

“…RATIONALE:Activin receptor-like kinase-1 (ALK1) is an endothelial transforming growth factor β receptor involved in angiogenesis. ALK1 expression is high in…”
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The role of the TGF-β coreceptor endoglin in cancer by Pérez-Gómez, Eduardo, Del Castillo, Gaelle, Juan Francisco, Santibáñez, López-Novoa, Jose Miguel, Bernabéu, Carmelo, Quintanilla, Miguel

“…Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and…”
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Immunosuppressor FK506 increases endoglin and activin receptor-like kinase 1 expression and modulates transforming growth factor-β1 signaling in endothelial cells by Albiñana, Virginia, Sanz-Rodríguez, Francisco, Recio-Poveda, Lucía, Bernabéu, Carmelo, Botella, Luisa M

“…Hereditary hemorrhagic telangiectasia (HHT), or Rendu-Osler-Weber syndrome, is an autosomal-dominant vascular disease. The clinical manifestations are…”
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Extracellular signal–regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells by Puig-Kröger, Amaya, Relloso, Miguel, Fernández-Capetillo, Oskar, Zubiaga, Ana, Silva, Augusto, Bernabéu, Carmelo, Corbı́, Angel L.

“…Dendritic cells (DC) are highly specialized antigen-presenting cells that on activation by inflammatory stimuli (eg, tumor necrosis factor α [TNF-α] and…”
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Review of Pharmacological Strategies with Repurposed Drugs for Hereditary Hemorrhagic Telangiectasia Related Bleeding by Albiñana, Virginia, Cuesta, Angel M, Rojas-P, Isabel de, Gallardo-Vara, Eunate, Recio-Poveda, Lucía, Bernabéu, Carmelo, Botella, Luisa María

“…The diagnosis of hereditary hemorrhagic telangiectasia (HHT) is based on the Curaçao criteria: epistaxis, telangiectases, arteriovenous malformations in…”
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Estrogen therapy for hereditary haemorrhagic telangiectasia (HHT): Effects of raloxifene, on Endoglin and ALK1 expression in endothelial cells by Albiñana, Virginia, Bernabeu-Herrero, Maria E, Zarrabeitia, Roberto, Bernabéu, Carmelo, Botella, Luisa M

“…Hereditary haemorrhagic telangiectasia (HHT), or Rendu-Osler-Weber syndrome, is an autosomal dominant vascular disease. The clinical manifestations are…”
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Research on potential biomarkers in hereditary hemorrhagic telangiectasia by Botella, Luisa-María, Albiñana, Virginia, Ojeda-Fernandez, Luisa, Recio-Poveda, Lucia, Bernabéu, Carmelo

“…Hereditary hemorrhagic telangiectasia (HHT) is a genetically heterogeneous disorder, involving mutations in two predominant genes known as Endoglin (ENG; HHT1)…”
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Soluble endoglin antagonizes Met signaling in spindle carcinoma cells by del Castillo, Gaelle, Sánchez-Blanco, Esther, Martín-Villar, Ester, Valbuena-Diez, Ana C, Langa, Carmen, Pérez-Gómez, Eduardo, Renart, Jaime, Bernabéu, Carmelo, Quintanilla, Miguel

“…Increased levels of soluble endoglin (Sol-Eng) correlate with poor outcome in human cancer. We have previously shown that shedding of membrane endoglin, and…”
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Transcriptional activation of endoglin and transforming growth factor-β signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury by Botella, Luisa M., Sánchez-Elsner, Tilman, Sanz-Rodriguez, Francisco, Kojima, Soichi, Shimada, Jun, Guerrero-Esteo, Mercedes, Cooreman, Michael P., Ratziu, Vlad, Langa, Carmen, Vary, CalvinP.H., Ramı́rez, Jose R., Friedman, Scott, Bernabéu, Carmelo

“…Endoglin is an endothelial membrane glycoprotein involved in cardiovascular morphogenesis and vascular remodeling. It associates with transforming growth…”
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Hereditary Hemorrhagic Telangiectasia, a Vascular Dysplasia Affecting the TGF-β Signaling Pathway by Africa Fernández-L, Francisco Sanz-Rodriguez, Francisco J. Blanco, Carmelo Bernabéu, Luisa M. Botella

“…Hereditary hemorrhagic telangiectasia (HHT) is caused by mutations in endoglin (ENG; HHT1) or ACVRL1/ALK1 (HHT2) genes and is an autosomal dominant vascular…”
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Characterization of murine S-endoglin isoform and its effects on tumor development by PEREZ-GOMEZ, Eduardo, ELENO, Nélida, LOPEZ-NOVOA, Jose Miguel, RAMIREZ, Jose Ramon, VELASCO, Beatriz, LETARTE, Michelle, BERNABEU, Carmelo, QUINTANILLA, Miguel

“…Endoglin is a transmembrane glycoprotein that acts as an auxiliary receptor for transforming growth factor-beta (TGF-beta) and modulates cellular responses to…”
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A Role for Endoglin as a Suppressor of Malignancy during Mouse Skin Carcinogenesis by PEREZ-GOMEZ, Eduardo, VILLA-MORALES, Maria, SANTOS, Javier, FERNANDEZ-PIQUERAS, José, GAMALLO, Carlos, DOTOR, Javier, BERNABEU, Carmelo, QUINTANILLA, Miguel

“…Endoglin is a membrane glycoprotein that acts as a coreceptor for transforming growth factor-beta. We and others have previously suggested a function of…”
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