Search Results - "Berman, Jennifer R"

Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing by Miyaoka, Yuichiro, Berman, Jennifer R., Cooper, Samantha B., Mayerl, Steven J., Chan, Amanda H., Zhang, Bin, Karlin-Neumann, George A., Conklin, Bruce R.

“…Precise genome-editing relies on the repair of sequence-specific nuclease-induced DNA nicking or double-strand breaks (DSBs) by homology-directed repair (HDR)…”
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Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells by DeWitt, Mark A, Magis, Wendy, Bray, Nicolas L, Wang, Tianjiao, Berman, Jennifer R, Urbinati, Fabrizia, Heo, Seok-Jin, Mitros, Therese, Muñoz, Denise P, Boffelli, Dario, Kohn, Donald B, Walters, Mark C, Carroll, Dana, Martin, David I K, Corn, Jacob E

“…Genetic diseases of blood cells are prime candidates for treatment through ex vivo gene editing of CD34 hematopoietic stem/progenitor cells (HSPCs), and a…”
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Germ-Cell Loss Extends C. elegans Life Span through Regulation of DAF-16 by kri-1 and Lipophilic-Hormone Signaling by Berman, Jennifer R., Kenyon, Cynthia

“…In C. elegans, removing the germ cells extends life span by triggering the nuclear localization and activation of the DAF-16/FOXO transcription factor in the…”
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A Digital PCR-Based Method for Efficient and Highly Specific Screening of Genome Edited Cells by Findlay, Scott D, Vincent, Krista M, Berman, Jennifer R, Postovit, Lynne-Marie

“…The rapid adoption of gene editing tools such as CRISPRs and TALENs for research and eventually therapeutics necessitates assays that can rapidly detect and…”
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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan by Libina, Nataliya, Berman, Jennifer R., Kenyon, Cynthia

“…In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have…”
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The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling by Yamawaki, Tracy M, Berman, Jennifer R, Suchanek-Kavipurapu, Monika, McCormick, Mark, Gaglia, Marta Maria, Lee, Seung-Jae, Kenyon, Cynthia

“…In Caenorhabditis elegans and Drosophila melanogaster, removing the germline precursor cells increases lifespan. In worms, and possibly also in flies, this…”
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Large multiallelic copy number variations in humans by Handsaker, Robert E, Van Doren, Vanessa, Berman, Jennifer R, Genovese, Giulio, Kashin, Seva, Boettger, Linda M, McCarroll, Steven A

“…Steven McCarroll and colleagues report an analysis of multiallelic copy number variants (mCNVs). They characterize mCNVs in 849 whole-genome sequences from the…”
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Droplet Digital™ PCR: Multiplex Detection of KRAS Mutations in Formalin-Fixed, Paraffin-Embedded Colorectal Cancer Samples by Wei Yang, Dawne N Shelton, Jennifer R Berman, Bin Zhang, Samantha Cooper, Svilen Tzonev, Eli Hefner, John F Regan

“…Targeted therapies in many cancers have allowed unprecedented progress in the treatment of disease. However, routine implementation of genomic testing is…”
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Droplet Digital™ PCR: Multiplex Detection of KRAS Mutations in Formalin-Fixed, Paraffin-Embedded Colorectal Cancer Samples by Wei Yang, Dawne N Shelton, Jennifer R Berman, Bin Zhang, Samantha Cooper, Svilen Tzonev, Eli Hefner, John F Regan

“…Targeted therapies in many cancers have allowed unprecedented progress in the treatment of disease. However, routine implementation of genomic testing is…”
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Multiplexed Target Detection Using DNA-Binding Dye Chemistry in Droplet Digital PCR by McDermott, Geoffrey P, Do, Duc, Litterst, Claudia M, Maar, Dianna, Hindson, Christopher M, Steenblock, Erin R, Legler, Tina C, Jouvenot, Yann, Marrs, Samuel H, Bemis, Adam, Shah, Pallavi, Wong, Josephine, Wang, Shenglong, Sally, David, Javier, Leanne, Dinio, Theresa, Han, Chunxiao, Brackbill, Timothy P, Hodges, Shawn P, Ling, Yunfeng, Klitgord, Niels, Carman, George J, Berman, Jennifer R, Koehler, Ryan T, Hiddessen, Amy L, Walse, Pramod, Bousse, Luc, Tzonev, Svilen, Hefner, Eli, Hindson, Benjamin J, Cauly, Thomas H, Hamby, Keith, Patel, Viresh P, Regan, John F, Wyatt, Paul W, Karlin-Neumann, George A, Stumbo, David P, Lowe, Adam J

“…Two years ago, we described the first droplet digital PCR (ddPCR) system aimed at empowering all researchers with a tool that removes the substantial…”
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Analytical validation of a multi-cancer early detection test with cancer signal origin using a cell-free DNA-based targeted methylation assay by Alexander, Gregory E, Lin, Wendy, Ortega, Fabian E, Ramaiah, Madhuvanthi, Jung, Byoungsok, Ji, Lijuan, Revenkova, Ekaterina, Shah, Payal, Croisetiere, Christian, Berman, Jennifer R, Eubank, Lane, Naik, Gunjan, Brooks, Jacqueline, Mich, Andrea, Shojaee, Seyedmehdi, Ronaghi, Neda, Chawla, Hemanshi, Hou, Xinyi, Liu, Qinwen, Yakym, Christopher-James A V, Moradi, Patriss Wais, Halks-Miller, Meredith, Aravanis, Alexander M, Parpart-Li, Sonya, Hunkapiller, Nathan

“…The analytical validation is reported for a targeted methylation-based cell-free DNA multi-cancer early detection test designed to detect cancer and predict…”
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Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system by Berman, Jennifer R., Skariah, Gemini, Maro, Géraldine S., Mignot, Emmanuel, Mourrain, Philippe

“…Melanin‐concentrating hormone (MCH) regulates feeding and complex behaviors in mammals and pigmentation in fish. The relationship between fish and mammalian…”
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Effect of Estrogen Withdrawal on Nitric Oxide Synthase Expression and Apoptosis in the Rat Vagina by Berman, Jennifer R, McCarthy, Margaret M, Kyprianou, Natasha

“…Objectives. The physiology of the female sexual response and its molecular mediators remain poorly understood. Nitric oxide (NO) is synthesized in neurons and…”
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Healthy Animals with Extreme Longevity by Arantes-Oliveira, Nuno, Berman, Jennifer R., Kenyon, Cynthia

“…In the nematode Caenorhabditis elegans, mutations that inhibit insulin/IGF-1 (insulin-like growth factor 1) signaling, such as daf-2 insulin/IGF-1 receptor…”
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Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: a double-blind, placebo controlled study by Berman, Jennifer R, Berman, Laura A, Toler, Steven M, Gill, Jennifer, Haughie, Scott

“…We evaluated the efficacy and safety of sildenafil citrate in spontaneously or surgically postmenopausal women with female sexual arousal disorder (FSAD)…”
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Distinct Activities of the Germline and Somatic Reproductive Tissues in the Regulation of Caenorhabditis elegans' Longevity by Yamawaki, Tracy M, Arantes-Oliveira, Nuno, Berman, Jennifer R, Zhang, Peichuan, Kenyon, Cynthia

“…The two parts of the Caenorhabditis elegans reproductive system, the germ cells and the somatic reproductive tissues, each influence the life span of the…”
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Female Cosmetic Genital Reconstruction: a Review of Current Trends, Treatments, and Techniques by Gonzales-Alabastro, Christopher, Eilber, Karyn S., Anger, Jennifer T., Berman, Jennifer R.

“…Purpose of Review To examine the peer-reviewed publications on the topic of female cosmetic genital surgery (FCGS) and discuss recent trends, the factors…”
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Female sexual dysfunction: incidence, pathophysiology, evaluation, and treatment options by Berman, Jennifer R, Berman, Laura, Goldstein, Irwin

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Physiology and pathophysiology of female sexual function and dysfunction by BERMAN, Jennifer R, BASSUK, Javier

“…Female sexual dysfunction is age-related, progressive, and highly prevalent, affecting 30%-50% of American women. While there are emotional and relational…”
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Sexual dysfunction in the older woman: An overview of the current understanding and management by WALSH, Kathleen E, BERMAN, Jennifer R

“…Sexuality is one of the most important quality of life issues for both men and women. Sexual dysfunction is a highly prevalent, age-related and progressive…”
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