Search Results - "Berlow, Rebecca B"

Hypersensitive termination of the hypoxic response by a disordered protein switch by Berlow, Rebecca B., Dyson, H. Jane, Wright, Peter E.

“…The intrinsically disordered CITED2 negative feedback regulator displaces the tightly bound hypoxia-inducible transcription factor HIF-1α from their common…”
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Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation by Berlow, Rebecca B., Dyson, H. Jane, Wright, Peter E.

“…Allosteric regulatory processes are implicated at all levels of biological function. Recent advances in our understanding of the diverse and functionally…”
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Functional advantages of dynamic protein disorder by Berlow, Rebecca B., Dyson, H. Jane, Wright, Peter E.

“…Intrinsically disordered proteins participate in many important cellular regulatory processes. The absence of a well-defined structure in the free state of a…”
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Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins by Berlow, Rebecca B, Dyson, H Jane, Wright, Peter E

“…Intrinsically disordered proteins must compete for binding to common regulatory targets to carry out their biological functions. Previously, we showed that the…”
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Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion by Loria, J. Patrick, Berlow, Rebecca B, Watt, Eric D

“…In many enzymes, conformational changes that occur along the reaction coordinate can pose a bottleneck to the rate of conversion of substrates to products…”
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A Dual Regulatory Role for the Disordered C-Terminus of Protein Kinase Cα by Berlow, Rebecca B.

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Multivalency emerges as a common feature of intrinsically disordered protein interactions by Sipko, Emily L., Chappell, Garrett F., Berlow, Rebecca B.

“…Intrinsically disordered proteins (IDPs) use their unique molecular properties and conformational plasticity to interact with cellular partners in a wide…”
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An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization by Usui-Ouchi, Ayumi, Aguilara, Edith, Murinello, Salome, Prins, Mitchell, Gantner, Marin L., Wright, Peter E., Berlow, Rebecca B., Friedlander, Martin

“…Retinal neovascularization (NV), a leading cause of vision loss, results from localized hypoxia that stabilizes the hypoxia-inducible transcription factors…”
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Role of Backbone Dynamics in Modulating the Interactions of Disordered Ligands with the TAZ1 Domain of the CREB-Binding Protein by Berlow, Rebecca B, Martinez-Yamout, Maria A, Dyson, H. Jane, Wright, Peter E

“…The intrinsically disordered transactivation domains of HIF-1α and CITED2 compete for binding of the TAZ1 domain of the CREB-binding protein by a…”
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Redox-dependent structure and dynamics of macrophage migration inhibitory factor reveal sites of latent allostery by Skeens, Erin, Gadzuk-Shea, Meagan, Shah, Dilip, Bhandari, Vineet, Schweppe, Devin K., Berlow, Rebecca B., Lisi, George P.

“…Macrophage migration inhibitory factor (MIF) is a multifunctional immunoregulatory protein that is a key player in the innate immune response. Given its…”
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Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis by Usui‐Ouchi, Ayumi, Eade, Kevin, Giles, Sarah, Ideguchi, Yoichiro, Ouchi, Yasuo, Aguilar, Edith, Wei, Guoqin, Marra, Kyle V., Berlow, Rebecca B., Friedlander, Martin

“…Retinal neovascularization (NV) is the major cause of severe visual impairment in patients with ischemic eye diseases. While it is known that retinal microglia…”
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Glutamine-rich regions of the disordered CREB transactivation domain mediate dynamic intra- and intermolecular interactions by Martinez-Yamout, Maria A, Nasir, Irem, Shnitkind, Sergey, Ellis, Jamie P, Berlow, Rebecca B, Kroon, Gerard, Deniz, Ashok A, Dyson, H Jane, Wright, Peter E

“…The cyclic AMP response element (CRE) binding protein (CREB) is a transcription factor that contains a 280-residue N-terminal transactivation domain and a…”
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The molecular basis of allostery in a facilitated dissociation process by Appling, Francis D., Berlow, Rebecca B., Stanfield, Robyn L., Dyson, H. Jane, Wright, Peter E.

“…Facilitated dissociation provides a mechanism by which high-affinity complexes can be rapidly disassembled. The negative feedback regulator CITED2 efficiently…”
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Tight complexes from disordered proteins by Berlow, Rebecca B., Wright, Peter E.

“…Charged groups on protein surfaces often take part in molecular interactions. Two unstructured proteins have been found to use charge complementarity to form a…”
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Role of Loop−Loop Interactions in Coordinating Motions and Enzymatic Function in Triosephosphate Isomerase by Wang, Yan, Berlow, Rebecca B, Loria, J. Patrick

“…The enzyme triosephosphate isomerase (TIM) has been used as a model system for understanding the relationship between protein sequence, structure, and…”
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Substrate-Dependent Millisecond Domain Motions in DNA Polymerase β by Berlow, Rebecca B., Swain, Monalisa, Dalal, Shibani, Sweasy, Joann B., Loria, J. Patrick

“…DNA polymerase β (Pol β) is a  39-kDa enzyme that performs the vital cellular function of repairing damaged DNA. Mutations in Pol β have been linked to various…”
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Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease by Eade, Kevin, Gantner, Marin L., Hostyk, Joseph A., Nagasaki, Takayuki, Giles, Sarah, Fallon, Regis, Harkins-Perry, Sarah, Baldini, Michelle, Lim, Esther W., Scheppke, Lea, Dorrell, Michael I., Cai, Carolyn, Baugh, Evan H., Wolock, Charles J., Wallace, Martina, Berlow, Rebecca B., Goldstein, David B., Metallo, Christian M., Friedlander, Martin, Allikmets, Rando

“…Macular telangiectasia type 2 (MacTel) is a progressive, late-onset retinal degenerative disease linked to decreased serum levels of serine that elevate…”
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Value of a Hydrogen Bond in Triosephosphate Isomerase Loop Motion by Berlow, Rebecca B, Igumenova, Tatyana I, Loria, J. Patrick

“…The motion of the active site loop (loop 6) in triosephosphate isomerase is investigated in solution by TROSY NMR spin-relaxation experiments. The data show…”
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Backbone Dynamics of the TAZ1 Domain of the Creb-Binding Protein Modulate Competition Between Disordered Ligands by Berlow, Rebecca B., Dyson, Jane, Wright, Peter E.

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The molecular basis of allostery in a facilitated dissociation process by Appling, Francis D., Berlow, Rebecca B., Stanfield, Robyn L., Dyson, H. Jane, Wright, Peter E.

“…Not provided…”
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