Search Results - "Berleth, Erica"

A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers by Singh, Sunanda, Murillo, Genoveva, Richner, Justin, Singh, Samara P., Berleth, Erica, Kumar, Vijay, Mehta, Rajendra, Ramiya, Vijay, Parihar, Ashutosh S.

“…STAT3 and KRAS regulate cell proliferation, survival, apoptosis, cell migration, and angiogenesis. Aberrant expression of STAT3 and mutant active forms of KRAS…”
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TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-κB-induced increase in cFLIP by Seol, Ji-Yeon, Mihich, Enrico, Berleth, Erica S.

“…•pI∼5.5 TAPF prevents apoptosis induced by TNF but not by TRAIL, Fas or doxorubicin.•TAPF prevents TNF-induced, but not Fas-induced, cleavage of caspases 8, 9,…”
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Doxorubicin induces specific immune functions and cytokine expression in peritoneal cells by UJHAZY, Peter, ZALESKIS, Gintaras, MIHICH, Enrico, EHRKE, M. Jane, BERLETH, Erica S

“…To examine the basis of the immune modulation induced by the anticancer agent doxorubicin (DOX), the immunophenotype, tumoricidal activity, cytokine protein…”
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Fanconi Anemia Pathway Defects in Neoplasia: Cause or Effect? by Berleth, Erica S.

“…Commentary to: Functional Screen of the Fanconi Anemia Pathway in Cancer Cells by Fancd2 Immunoblot Michiel S. Van der Heijden, Jonathan R. Brody, and Scott E…”
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Mechanism of Ubiquitin Conjugating Enzyme E2-230K:  Catalysis Involving a Thiol Relay? by Berleth, Erica S, Pickart, Cecile M

“…Covalent conjugation of ubiquitin to intracellular proteins is a signal for degradation by the 26S protease. Conjugation is usually accomplished by the…”
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Identification, characterization, and cloning of TIP-B1, a novel protein inhibitor of tumor necrosis factor-induced lysis by BERLETH, E. S, NADADUR, S, HENN, A. D, EPPOLITO, C, SHIOJIRI, S, GURTOO, H. L, EHRKE, M. J, MIHICH, E

“…Some cancer cells evade elimination by virtue of their insensitivity to agents that induce apoptosis. Conversely, the side effects of anticancer agents could…”
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Expression, tissue distribution, and cellular localization of the antiapoptotic TIP-B1 protein by Berleth, E S, Masso-Welch, P A, Kazim, L A, Ip, M M, Mihich, E, Ehrke, M J

“…TIP‐B1 is a novel 27‐kDa protein isolated from the cytosol of tumornecrosis factor (TNF)‐stimulated cells. Cells preincubated with TIP‐B1are protected from…”
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A novel, arsenite-sensitive E2 of the ubiquitin pathway: purification and properties by Klemperer, Nancy S, Berleth, Erica S, Pickart, Cecile M

“…In the multienzyme ubiquitin-dependent proteolytic pathway, conjugation of ubiquitin to target proteins serves as a signal for protein degradation. Rabbit…”
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A novel tumor necrosis factor-α inhibitory protein, TIP-B1 by Berleth, Erica S, Henn, Alicia D, Gurtoo, Hira L, Wollman, Robert, Alderfer, James L, Mihich, Enrico, Ehrke, M.Jane

“…TIP-B1, a novel TNF inhibitory protein, has been identified, purified and characterized from cytosolic extracts of TNF-treated human fibroblasts, and a partial…”
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Doxorubicin plus interleukin-2 chemoimmunotherapy against breast cancer in mice by EWENS, Andrew, LIQUN LUO, BERLETH, Erica, ALDERFER, James, WOLLMAN, Robert, BIN HAFEEZ, Bilal, KANTER, Peter, MIHICH, Enrico, EHRKE, M. Jane

“…As recently characterized, following s.c. implantation into syngeneic C57BL/6 mice, E0771 tumor invades locally into dermal layers and peritoneum, metastasizes…”
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Evidence for the involvement of ecto‐5′‐nucleotidase (CD73) in drug resistance by Ujházy, Peter, Berleth, Erica S., Pietkiewicz, Joelle M., Kitano, Haruhisa, Skaar, Jeffrey R., Ehrke, M. Jane, Mihich, Enrico

“…Increased ecto‐5′‐nucleotidase (ecto‐5′NT) protein expression in several multidrug‐resistant (MDR) cell lines, documented previously by our group, suggests…”
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Protective specific immunity induced by doxorubicin plus TNF‐α combination treatment of EL4 lymphoma–bearing C57BL/6 mice by Ehrke, M. Jane, Verstovšek, Srdan, Maccubbin, Darbie L., Ujházy, Peter, Zaleskis, Gintaras, Berleth, Erica, Mihich, Enrico

“…The therapeutic efficacy of a single (day 8), moderate dose (4 mg/kg, i.v.) of doxorubicin (DOX, Adriamycin) combined with recombinant human TNF‐α (3 different…”
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Changes in cytosol and membrane TNF inhibitory protein‐B1 levels associated with protection from TNF‐induced cytotoxicity by Henn, Alicia D., Berleth, Erica S., Mihich, Enrico, Ehrke, M. Jane

“…ABSTRACT Tumor necrosis factor‐α (TNF) at low, noncytotoxic concentrations induces factors that protect cells against cytotoxic concentrations of TNF alone or…”
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Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme by Sung, P, Berleth, E, Pickart, C, Prakash, S, Prakash, L

“…The RAD6 gene of Saccharomyces cerevisiae encodes a 20 kd ubiquitin conjugating (E2) enzyme that is required for DNA repair, DNA damage-induced mutagenesis,…”
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Inhibition of ubiquitin-protein ligase (E3) by mono- and bifunctional phenylarsenoxides. Evidence for essential vicinal thiols and a proximal nucleophile by BERLETH, E. S, KASPEREK, E. M, GRILL, S. P, BRAUNSCHEIDEL, J. A, GRAZIANI, L. A, PICKART, C. M

“…Trivalent arsenoxides bind to vicinal thiol groups of proteins. We showed previously that the simplest trivalent arsenoxide, inorganic arsenite, inhibits…”
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A reactive nucleophile proximal to vicinal thiols is an evolutionarily conserved feature in the mechanism of Arg aminoacyl-tRNA protein transferase by Berleth, E S, Li, J, Braunscheidel, J A, Pickart, C M

“…Aminoacyl-tRNA protein transferases post-translationally aminoacylate protein N-termini. At least in part, these enzymes function to allow a subset of cellular…”
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Effect of perioperative chemoimmunotherapy with cyclophosphamide and autologous tumor vaccine in murine MBT-2 bladder cancer by Tzai, T S, Huben, R P, Zaleskis, G, Berleth, E S, Ehrke, M J, Mihich, E

“…The in vitro cytotoxic activity of splenocytes from C3H/He mice implanted subcutaneously with 10(6) syngeneic MBT-2 tumor cells on day 0 was significantly…”
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