Search Results - "Berkes, Dusan"

Visible-Light-Promoted Cross-Coupling of N‑Alkylpyridinium Salts and Nitrostyrenes by Ferko, Branislav, Marčeková, Michaela, Detková, Katarína Ráchel, Doháňošová, Jana, Berkeš, Dušan, Jakubec, Pavol

“…A stereoselective, denitrative cross-coupling of β-nitrostyrenes with N-alkylpyridinium salts for the preparation of functionalized styrenes has been…”
Get full text

Antibacterial Electrospun Polycaprolactone Nanofibers Reinforced by Halloysite Nanotubes for Tissue Engineering by Khunová, Viera, Kováčová, Mária, Olejniková, Petra, Ondreáš, František, Špitalský, Zdenko, Ghosal, Kajal, Berkeš, Dušan

“…Due to its slow degradation rate, polycaprolactone (PCL) is frequently used in biomedical applications. This study deals with the development of antibacterial…”
Get full text

Stereodivergent synthesis of cyclic γ-aminobutyric acid – GABA analogues by Ďuriš, Andrej, Berkeš, Dušan, Jakubec, Pavol

“…[Display omitted] •Straightforward and robust enantioselective synthesis of cyclic GABA analogues.•Diastereoselective intramolecular oxa-Michael…”
Get full text

Total Synthesis of Hemerocallisamine I Paved by Gram-Scale Synthesis of (2 S ,4 S )-4-Hydroxyglutamic Acid Lactone by Pinčeková, Lucia, Jančiová, Eva, Berkeš, Dušan, Gyepes, Róbert, Kolarovič, Andrej, Caletková, Oľga

“…Total synthesis of the 2-formylpyrrole alkaloid hemerocallisamine I is presented, both in racemic and enantiopure form. Our synthetic strategy involves (2 ,4…”
Get full text

Crystallization Does It All: An Alternative Strategy for Stereoselective Aza-Henry Reaction by Marčeková, Michaela, Gerža, Peter, Šoral, Michal, Moncol, Ján, Berkeš, Dušan, Kolarovič, Andrej, Jakubec, Pavol

“…An efficient and experimentally straightforward method for the stereoselective synthesis of a variety of β-nitro-α-amino carboxylic acids via aza-Henry…”
Get full text

Stereoselective Synthesis of Functionalized α‑Amino Acids Isolated by Filtration by Sivák, Ivan, Toběrný, Michal, Kyselicová, Andrea, Caletková, Ol’ga, Berkeš, Dušan, Jakubec, Pavol, Kolarovič, Andrej

“…Crystallization-induced diastereomer transformation (CIDT) represents a highly appealing and convenient synthetic tool. Despite its numerous advantages, it…”
Get full text

Stereoselective Mannich Reaction Driven by Crystallization by Čierna, Michaela, Markus, Jozef, Doháňošová, Jana, Moncol, Ján, Jakubec, Pavol, Berkeš, Dušan, Caletková, Oľga

“…Herein we disclose an efficient and experimentally straightforward method for the stereoselective synthesis of a variety of α‐substituted Mannich salts. This…”
Get full text

Chemistry and Biology of HPAs: A Family of Ceramide Trafficking Inhibitors by Berkeš, Dušan, Daïch, Adam, Santos, Cécile, Ballereau, Stéphanie, Génisson, Yves

“…In 2001, two years before the disclosure of the CERT‐associated Cer transfer machinery, N‐(3‐hydroxy‐1‐hydroxymethyl‐3‐phenylpropyl)alkanamides (HPAs) were…”
Get full text

Ceramide analog [18F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer’s disease transgenic mice by functioning as a metabolic probe by Crivelli, Simone M., van Kruining, Daan, Luo, Qian, Stevens, Jo A. A., Giovagnoni, Caterina, Paulus, Andreas, Bauwens, Matthias, Berkes, Dusan, de Vries, Helga E., Mulder, Monique T., Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V., Dehairs, Jonas, Mottaghy, Felix M., Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar

“…The metabolism of ceramides is deregulated in the brain of Alzheimer’s disease (AD) patients and is associated with apolipoprotein (APO) APOE4 and amyloid-β…”
Get full text

Expedient and Practical Synthesis of CERT-Dependent Ceramide Trafficking Inhibitor HPA-12 and Its Analogues by Ďuriš, Andrej, Wiesenganger, Tomáš, Moravčíková, Daniela, Baran, Peter, Kožíšek, Jozef, Daïch, Adam, Berkeš, Dušan

“…The practical stereodivergent route to both syn- and anti-diastereomers of 1-substituted 3-aminobutane-1,4-diols based on the crystallization-induced…”
Get full text

Silver‐Catalyzed Diastereoselective Synthesis of Spirocyclic Pyrrolidine‐Lactones by 1,3‐Dipolar Cycloaddition by García‐Mingüens, Eduardo, Caletková, Oľga, Berkeš, Dušan, Nájera, Carmen, Sansano, José M.

“…The preparation of two enantiomerically enriched amino lactones as chiral starting substrates for asymmetric 1,3‐dipolar cycloadditions is described. They act…”
Get full text

Straightforward synthesis of functionalized (E)-3-acylacrylic acids by Sivák, Ivan, Václav, Jakub, Berkeš, Dušan, Kolarovič, Andrej

“…An experimentally simple, mild and straightforward synthetic route towards diversely functionalized (E)-3-acylacrylic acids is described, with…”
Get full text

Indolylglycines Backbones in the Synthesis of Enantiopure 3,3‐Spiroindolenines, Indolyl Tetracyclic Hemiaminals, and 3‐Indolyl‐maleimides Frameworks by Markus, Jozef, Ferko, Branislav, Berkeš, Dušan, Moncol, Ján, Lawson, Ata Martin, Othman, Mohamed, Daïch, Adam

“…This paper describes the synthesis of novel N‐substituted 3‐indolylglycines (3IGs), in high yields and optical purity via three‐component Mannich reaction…”
Get full text

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles by Crivelli, Simone M., Giovagnoni, Caterina, Zhu, Zhihui, Tripathi, Priyanka, Elsherbini, Ahmed, Quadri, Zainuddin, Pu, Jian, Zhang, Liping, Ferko, Branislav, Berkes, Dusan, Spassieva, Stefka D., Martinez‐Martinez, Pilar, Bieberich, Erhard

“…The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we…”
Get full text

Chromatography-free stereoselective synthesis of (R)-3-benzylpiperidine by Sivak, Ivan, Berkes, Dusan, Kozisek, Jozef, Kolarovic, Andrej

“…[Display omitted] The present study describes aza-Michael addition reactions of 4-aroylpent-4-enoic acids with (R)-phenylglycinol. Subsequent spontaneous…”
Get full text

Development and Optimization of a High-Throughput Screening Assay for Rapid Evaluation of Lipstatin Production by Streptomyces Strains by Híreš, Michal, Rapavá, Nora, Šimkovič, Martin, Varečka, Ľudovít, Berkeš, Dušan, Kryštofová, Svetlana

“…Pancreatic lipase inhibitors, such as tetrahydrolipstatin (orlistat), are used in anti-obesity treatments. Orlistat is the only anti-obesity drug approved by…”
Get full text

FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer’s disease expressing APOE4 by Crivelli, Simone M., Luo, Qian, Kruining, Daan van, Giovagnoni, Caterina, Mané-Damas, Marina, den Hoedt, Sandra, Berkes, Dusan, De Vries, Helga E., Mulder, Monique T., Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V., Dehairs, Jonas, Wijnands, Erwin P.M., Bieberich, Erhard, Losen, Mario, Martinez-Martinez, Pilar

“…The protection mediated by the bioactive sphingolipid sphingosine-1-phosphate (S1P) declines during Alzheimer’s disease (AD) progression, especially in…”
Get full text

Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT by Ďuriš, Andrej, Daïch, Adam, Santos, Cécile, Fleury, Laurence, Ausseil, Frédéric, Rodriguez, Frédéric, Ballereau, Stéphanie, Génisson, Yves, Berkeš, Dušan

“…A series of 12 analogues of the Cer transfer protein (CERT) antagonist HPA‐12 with long aliphatic chains were prepared as their (1R,3S)‐syn and (1R,3R)‐anti…”
Get full text

Crystallisation-induced asymmetric transformation (CIAT) for the synthesis of dipeptides containing homophenylalanine by Jakubec, Pavol, Berkeš, Dušan

“…A novel synthesis of highly enantioenriched dipeptides containing homophenylalanine is described. The process involves a crystallisation-induced asymmetric…”
Get full text

CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease by Crivelli, Simone M., Luo, Qian, Stevens, Jo A.A., Giovagnoni, Caterina, van Kruining, Daan, Bode, Gerard, den Hoedt, Sandra, Hobo, Barbara, Scheithauer, Anna-Lena, Walter, Jochen, Mulder, Monique T., Exley, Christopher, Mold, Matthew, Mielke, Michelle M., De Vries, Helga E., Wouters, Kristiaan, van den Hove, Daniel L. A., Berkes, Dusan, Ledesma, María Dolores, Verhaagen, Joost, Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar

“…Abstract Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD)…”
Get full text