Search Results - "Berkers, Celia R."

The Influence of Metabolism on Drug Response in Cancer by Zaal, Esther A, Berkers, Celia R

“…Resistance to therapeutic agents, either intrinsic or acquired, is currently a major problem in the treatment of cancers and occurs in virtually every type of…”
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Metabolic Regulation by p53 Family Members by Berkers, Celia R., Maddocks, Oliver D.K., Cheung, Eric C., Mor, Inbal, Vousden, Karen H.

“…The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of…”
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A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer by Jin, Haojie, Wang, Siying, Zaal, Esther A, Wang, Cun, Wu, Haiqiu, Bosma, Astrid, Jochems, Fleur, Isima, Nikita, Jin, Guangzhi, Lieftink, Cor, Beijersbergen, Roderick, Berkers, Celia R, Qin, Wenxin, Bernards, Rene

“…The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we…”
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Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion by Jansen, Jitske, Jansen, Katja, Neven, Ellen, Poesen, Ruben, Othman, Amr, van Mil, Alain, Sluijter, Joost, Torano, Javier Sastre, Zaal, Esther A., Berkers, Celia R., Esser, Diederik, Wichers, Harry J., van Ede, Karin, van Duursen, Majorie, Burtey, Stéphane, Verhaar, Marianne C., Meijers, Björn, Masereeuw, Rosalinde

“…Membrane transporters and receptors are responsible for balancing nutrient and metabolite levels to aid body homeostasis. Here, we report that proximal tubule…”
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Bridging the gap: advancing cancer cell culture to reveal key metabolic targets by Kes, Marjolein M G, Berkers, Celia R, Drost, Jarno

“…Metabolic rewiring is a defining characteristic of cancer cells, driving their ability to proliferate. Leveraging these metabolic vulnerabilities for…”
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SLC1A3 contributes to L‐asparaginase resistance in solid tumors by Sun, Jianhui, Nagel, Remco, Zaal, Esther A, Ugalde, Alejandro Piñeiro, Han, Ruiqi, Proost, Natalie, Song, Ji‐Ying, Pataskar, Abhijeet, Burylo, Artur, Fu, Haigen, Poelarends, Gerrit J, van de Ven, Marieke, van Tellingen, Olaf, Berkers, Celia R, Agami, Reuven

“…L‐asparaginase (ASNase) serves as an effective drug for adolescent acute lymphoblastic leukemia. However, many clinical trials indicated severe ASNase toxicity…”
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Bortezomib resistance in multiple myeloma is associated with increased serine synthesis by Zaal, Esther A, Wu, Wei, Jansen, Gerrit, Zweegman, Sonja, Cloos, Jacqueline, Berkers, Celia R

“…The proteasome inhibitor bortezomib (BTZ) is successfully applied in the treatment of multiple myeloma, but its efficacy is restricted by the wide-spread…”
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Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity by van Loosdregt, Jorg, Fleskens, Veerle, Fu, Juan, Brenkman, Arjan B., Bekker, Cornelis P.J., Pals, Cornelieke E.G.M., Meerding, Jenny, Berkers, Celia R., Barbi, Joseph, Gröne, Andrea, Sijts, Alice J.A.M., Maurice, Madelon M., Kalkhoven, Eric, Prakken, Berent J., Ovaa, Huib, Pan, Fan, Zaiss, Dietmar M.W., Coffer, Paul J.

“…Stable Foxp3 expression is required for the development of functional regulatory T (Treg) cells. Here, we demonstrate that the expression of the transcription…”
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Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37 by Peeters, Rens, Cuenca-Escalona, Jorge, Zaal, Esther A., Hoekstra, Anna T., Balvert, Anouk C. G., Vidal-Manrique, Marcos, Blomberg, Niek, van Deventer, Sjoerd J., Stienstra, Rinke, Jellusova, Julia, Giera, Martin, Hannibal, Luciana, Spiekerkoetter, Ute, ter Beest, Martin, Berkers, Celia R., van Spriel, Annemiek B.

“…The importance of fatty acid (FA) metabolism in cancer is well-established, yet the mechanisms underlying metabolic reprogramming remain elusive. Here, we…”
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P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance by Jiang, Xiangli, Baig, Ali Hyder, Palazzo, Giuliana, Del Pizzo, Rossella, Bortecen, Toman, Groessl, Sven, Zaal, Esther A., Amaya Ramirez, Cinthia Claudia, Kowar, Alexander, Aviles-Huerta, Daniela, Berkers, Celia R., Palm, Wilhelm, Tschaharganeh, Darjus, Krijgsveld, Jeroen, Loayza-Puch, Fabricio

“…Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different…”
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Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation by Chen, Jing, Zaal, Esther A., Berkers, Celia R., Ruijtenbeek, Rob, Garssen, Johan, Redegeld, Frank A.

“…Multiple myeloma (MM) is a hematological malignancy that exhibits aberrantly high levels of proteasome activity. While treatment with the proteasome inhibitor…”
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Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis by de Kivit, Sander, Mensink, Mark, Kostidis, Sarantos, Derks, Rico J.E., Zaal, Esther A., Heijink, Marieke, Verleng, Lotte J., de Vries, Evert, Schrama, Ellen, Blomberg, Niek, Berkers, Celia R., Giera, Martin, Borst, Jannie

“…Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses. As lipids impact cell signaling and function, we compare the lipid…”
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Deciphering metabolic crosstalk in context: lessons from inflammatory diseases by Verheijen, Fenne W. M., Tran, Thi N. M., Chang, Jung‐Chin, Broere, Femke, Zaal, Esther A., Berkers, Celia R.

“…Metabolism plays a crucial role in regulating the function of immune cells in both health and disease, with altered metabolism contributing to the pathogenesis…”
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Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules by Berkers, Celia R, de Jong, Annemieke, Schuurman, Karianne G, Linnemann, Carsten, Meiring, Hugo D, Janssen, Lennert, Neefjes, Jacques J, Schumacher, Ton N M, Rodenko, Boris, Ovaa, Huib

“…Peptide splicing, in which two distant parts of a protein are excised and then ligated to form a novel peptide, can generate unique MHC class I-restricted…”
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TNFR2 Costimulation Differentially Impacts Regulatory and Conventional CD4 + T-Cell Metabolism by Mensink, Mark, Tran, Thi Ngoc Minh, Zaal, Esther A, Schrama, Ellen, Berkers, Celia R, Borst, Jannie, de Kivit, Sander

“…CD4 conventional T cells (Tconvs) mediate adaptive immune responses, whereas regulatory T cells (Tregs) suppress those responses to safeguard the body from…”
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Metabolic changes underlying drug resistance in the multiple myeloma tumor microenvironment by Matamala Montoya, María, van Slobbe, Gijs J J, Chang, Jung-Chin, Zaal, Esther A, Berkers, Celia R

“…Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells in the bone marrow (BM). MM remains an incurable disease, with the…”
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Innate Immune Training of Human Macrophages by Cathelicidin Analogs by van Dijk, Albert, Anten, Jennifer, Bakker, Anne, Evers, Noah, Hoekstra, Anna T., Chang, Jung-Chin, Scheenstra, Maaike R., Veldhuizen, Edwin J. A., Netea, Mihai G., Berkers, Celia R., Haagsman, Henk P.

“…Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins…”
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Extracellular vesicles from seminal plasma interact with T cells in vitro and drive their differentiation into regulatory T‐cells by Zhang, Xiaogang, Greve, Patrick F., Minh, Thi Tran Ngoc, Wubbolts, Richard, Demir, Ayşe Y., Zaal, Esther A., Berkers, Celia R., Boes, Marianne, Stoorvogel, Willem

“…Seminal plasma induces immune tolerance towards paternal allogenic antigens within the female reproductive tract and during foetal development. Recent evidence…”
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Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib by Ovaa, Huib, Berkers, Celia R, Verdoes, Martijn, Lichtman, Eben, Fiebiger, Edda, Kessler, Benedikt M, Anderson, Kenneth C, Ploegh, Hidde L, Galardy, Paul J

“…Proteasome inhibitors, such as the dipeptide boronic acid bortezomib, are emerging as important tools in the treatment of the fatal hematologic malignancy…”
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Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7 by Bakker, Arnold H, Hoppes, Rieuwert, Linnemann, Carsten, Toebes, Mireille, Rodenko, Boris, Berkers, Celia R, Hadrup, Sine Reker, van Esch, Wim J.E, Heemskerk, Mirjam H.M, Ovaa, Huib, Schumacher, Ton N.M

“…Major histocompatibility complex (MHC) class I multimer technology has become an indispensable immunological assay system to dissect antigen-specific cytotoxic…”
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