Search Results - "Berkers, C"

Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic Sclerosis Patients by Ottria, A, Hoekstra, A T, Zimmermann, M, van der Kroef, M, Vazirpanah, N, Cossu, M, Chouri, E, Rossato, M, Beretta, L, Tieland, R G, Wichers, C G K, Stigter, E, Gulersonmez, C, Bonte-Mineur, F, Berkers, C R, Radstake, T R D J, Marut, W

“…Systemic sclerosis (SSc) is a rare chronic disease of unknown pathogenesis characterized by fibrosis of the skin and internal organs, vascular alteration, and…”
Get full text

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib by Chauhan, Dharminder, Catley, Laurence, Li, Guilan, Podar, Klaus, Hideshima, Teru, Velankar, Mugdha, Mitsiades, Constantine, Mitsiades, Nicolas, Yasui, Hiroshi, Letai, Anthony, Ovaa, Huib, Berkers, Celia, Nicholson, Benjamin, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Richardson, Paul, Palladino, Michael A., Anderson, Kenneth C.

“…Bortezomib therapy has proven successful for the treatment of relapsed and/or refractory multiple myeloma (MM); however, prolonged treatment is associated with…”
Get full text

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease by Nijholt, D A T, de Graaf, T R, van Haastert, E S, Oliveira, A Osório, Berkers, C R, Zwart, R, Ovaa, H, Baas, F, Hoozemans, J J M, Scheper, W

“…Protein folding stress in the endoplasmic reticulum (ER) may lead to activation of the unfolded protein response (UPR), aimed to restore cellular homeostasis…”
Get full text

Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials by Potts, B C, Albitar, M X, Anderson, K C, Baritaki, S, Berkers, C, Bonavida, B, Chandra, J, Chauhan, D, Cusack, Jr, J C, Fenical, W, Ghobrial, I M, Groll, M, Jensen, P R, Lam, K S, Lloyd, G K, McBride, W, McConkey, D J, Miller, C P, Neuteboom, S T C, Oki, Y, Ovaa, H, Pajonk, F, Richardson, P G, Roccaro, A M, Sloss, C M, Spear, M A, Valashi, E, Younes, A, Palladino, M A

“…The proteasome has emerged as an important clinically relevant target for the treatment of hematologic malignancies. Since the Food and Drug Administration…”
Get more information

Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells by KRAUS, M, RUCKRICH, T, DRIESSEN, C, REICH, M, GOGEL, J, BECK, A, KAMMER, W, BERKERS, C. R, BURG, D, OVERKLEEFT, H, OVAA, H

“…Proteasomal proteolysis relies on the activity of six catalytically active proteasomal subunits (beta1, beta2, beta5, beta1i, beta2i and beta5i). Applying a…”
Get full text

79 Roles of p53 in the Control of Metabolic Pathways by Vousden, K.H, Maddocks, O, Berkers, C, Cheung, E

Get full text

Immunotherapeutic potential for ceramide-based activators of iNKT cells by Berkers, Celia R., Ovaa, Huib

“…Invariant natural killer T (iNKT) cells are a subpopulation of T cells that are reactive with glycolipids that are bound by CD1d antigen-presenting molecules…”
Get full text

Stabilisation of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity by van Loosdregt, J, Fleskens, V, Fu, J, Brenkman, A B, Bekker, C PJ, Pals, C EGM, Meerding, J, Berkers, C R, Barbi, J, Grone, A, Sijts, A JAM, Maurice, M M, Kalkhoven, E, Prakken, B J, Ovaa, H, Pan, F, Zaiss, D MW, Coffer, P J

“…CD4 super(+) regulatory T cells (Treg) are key regulators of immune function and hold promise for therapy in a number of transplantation settings (1). The…”
Get full text

Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome by Groll, Michael, Berkers, Celia R., Ploegh, Hidde L., Ovaa, Huib

“…The dipeptide boronic acid bortezomib, also termed VELCADE ®, is a proteasome inhibitor now in use for the treatment of multiple myeloma, and its use for the…”
Get full text

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib by Ovaa, Huib, Berkers, Celia R, Verdoes, Martijn, Lichtman, Eben, Fiebiger, Edda, Kessler, Benedikt M, Anderson, Kenneth C, Ploegh, Hidde L, Galardy, Paul J

“…Proteasome inhibitors, such as the dipeptide boronic acid bortezomib, are emerging as important tools in the treatment of the fatal hematologic malignancy…”
Get full text

Bruikbaarheid van de Simbionix TURP-simulator voor de training van arts-assistenten urologie by Berkers, C. H. J., Tjiam, I. M., Schout, B. M. A., Brinkman, W. M., Koldewijn, E. L.

Get full text

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo by Verdoes, Martijn, Florea, Bogdan I, Menendez-Benito, Victoria, Maynard, Christa J, Witte, Martin D, van der Linden, Wouter A, van den Nieuwendijk, Adrianus M C H, Hofmann, Tanja, Berkers, Celia R, van Leeuwen, Fijs W B, Groothuis, Tom A, Leeuwenburgh, Michiel A, Ovaa, Huib, Neefjes, Jacques J, Filippov, Dmitri V, van der Marel, Gijs A, Dantuma, Nico P, Overkleeft, Herman S

“…The proteasome is an essential evolutionary conserved protease involved in many regulatory systems. Here, we describe the synthesis and characterization of the…”
Get full text