Staphylococcus aureus enterotoxin A- and B-specific IgE in chronic obstructive pulmonary disease

Staphylococcus aureus enterotoxin A- and B-specific IgE in chronic obstructive pulmonary disease

Sensitization to Staphylococcus aureus enterotoxins A (SEA) and B (SEB) has been associated with asthma severity, exacerbations, and disease control. Our study aimed to investigate if there are differences in serum SEA-IgE and SEB-IgE levels between patients with chronic obstructive pulmonary diseas...

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Bibliographic Details
Published in:Respiratory research Vol. 24; no. 1; pp. 1 - 225
Main Authors: Karakioulaki, Meropi, Berkemeier, Caroline Maria, Heijnen, Ingmar, Grize, Leticia, Papakonstantinou, Eleni, Goulas, Antonis, Tamm, Michael, Stolz, Daiana
Format: Journal Article
Language:English
Published: London BioMed Central Ltd 22-09-2023
BioMed Central
BMC
Subjects:
Allergens
Allergies
Allergy
Analysis
Asthma
Atopy
Biomarkers
Blood & organ donations
Blood circulation
Care and treatment
Chronic obstructive pulmonary disease
Complications and side effects
Control
COPD
Correspondence
Diagnosis
Disease control
Enterotoxins
Eosinophils
Identification and classification
IgE
Immunoglobulin E
Inflammation
Leukocytes (eosinophilic)
Lung diseases
Lymphocytes T
Nitric oxide
Obstructive lung disease
Rhinitis
Skin
Staphylococcal enterotoxin A
Staphylococcal enterotoxin A and B
Staphylococcus aureus
Staphylococcus aureus infections
Subgroups
Greece
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Summary:Sensitization to Staphylococcus aureus enterotoxins A (SEA) and B (SEB) has been associated with asthma severity, exacerbations, and disease control. Our study aimed to investigate if there are differences in serum SEA-IgE and SEB-IgE levels between patients with chronic obstructive pulmonary disease (COPD), asthma, and controls, and to assess the association between SE sensitization and COPD clinical parameters and Th2 inflammation biomarkers in two well-defined COPD cohorts. Our findings suggest that COPD patients do not exhibit higher SEA and SEB sensitization compared to asthma patients and controls. However, in COPD patients, the presence of atopy and allergy is associated with positivity for SEA-IgE and SEB-IgE. Consequently, these allergens may aid in identifying atopic or allergic subgroups within the COPD population, but they are not directly associated with the diagnosis of COPD, elevated circulating blood eosinophils, or fractional exhaled nitric oxide (FENO) levels.
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ISSN:1465-993X
1465-9921
1465-993X
1465-9921
DOI:10.1186/s12931-023-02520-4