Tranexamic acid decreases transfusion requirements during the modified pi-plasty procedure for sagittal craniosynostosis

The aim of our study was to evaluate the effectiveness of intraoperative tranexamic acid (TXA) administration in decreasing transfusion needs in patients undergoing modified pi-plasty. A retrospective study was performed using a population of 59 patients who underwent modified pi-plasty, wherein pat...

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Bibliographic Details
Published in:	Journal of cranio-maxillo-facial surgery Vol. 52; no. 5; pp. 619 - 621
Main Authors:	Caneira, Francisco, Santos, Maria Manuel, Faria, Cláudia C, Miguéns, José, Rodrigues, Idalina, Beristain, Marian, Guimarães-Ferreira, José
Format:	Journal Article
Language:	English
Published:	Scotland 01-05-2024
Subjects:	Antifibrinolytic Agents - therapeutic use Blood Loss, Surgical - prevention & control Blood Transfusion Craniosynostoses - surgery Female Hematocrit Humans Infant Male Plastic Surgery Procedures - methods Retrospective Studies Tranexamic Acid - administration & dosage Tranexamic Acid - therapeutic use Tranexamic acid Craniosynostosis Surgery
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Summary:	The aim of our study was to evaluate the effectiveness of intraoperative tranexamic acid (TXA) administration in decreasing transfusion needs in patients undergoing modified pi-plasty. A retrospective study was performed using a population of 59 patients who underwent modified pi-plasty, wherein patients who received TXA during surgery (study group, n = 26) were compared with patients who did not receive TXA (control group, n = 33). The primary study endpoints were intraoperative red blood cell substitution (%), postoperative red blood cell substitution (%), total red blood cell substitution (%), and hematocrit variation. Perioperative administration of TXA significantly decreased the total red blood cell substitution (62.90% vs 86.70%; p = 0.002) and resulted in a higher postoperative hematocrit (29.47% vs 27.53%; p = 0.060). In conclusion, perioperative administration of TXA significantly decreased blood transfusion requirements in patients with sagittal craniosynostosis undergoing modified pi-plasty.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1010-5182 1878-4119
DOI:	10.1016/j.jcms.2024.02.024