Search Results - "Berhanu, Abegaz M."
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Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors
Published in PloS one (01-04-2015)“…The continued burden of HIV in resource-limited regions such as parts of sub-Saharan Africa, combined with adverse effects and potential risks of resistance to…”
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Virtualizing the p-ANAPL library: a step towards drug discovery from African medicinal plants
Published in PloS one (05-03-2014)“…Natural products play a key role in drug discovery programs, both serving as drugs and as templates for the synthesis of drugs, even though the quantities and…”
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Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)
Published in Journal of ethnopharmacology (28-03-2008)“…The aim of this study was to evaluate the antimicrobial activity of the crude extract of the twigs of Dorstenia barteri (DBT) as well as that of four of the…”
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Homoisoflavonoids and xanthones from the tubers of wild and in vitro regenerated Ledebouria graminifolia and cytotoxic activities of some of the homoisoflavonoids
Published in Phytochemistry (Oxford) (01-03-2003)“…Five new and six known homoisoflavoniods, and two known xanthones were isolated from the bulbs of wild Ledebouria graminofolia. These same compounds were…”
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Atropo-Enantioselective Total Synthesis of Knipholone and Related Antiplasmodial Phenylanthraquinones
Published in Journal of organic chemistry (09-08-2002)“…The “lactone concept” has been efficiently employed for the first atropo-enantioselective synthesis of knipholone and related natural phenylanthraquinones…”
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Knipholone and related 4-phenylanthraquinones: structurally, pharmacologically, and biosynthetically remarkable natural products
Published in Natural product reports (01-08-2008)“…This review gives the first comprehensive overview of the rapidly emerging young class of 4-phenylanthraquinones isolated from the three genera Bulbine,…”
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Total synthesis, antiprotozoal and cytotoxicity activities of rhuschalcone VI and analogs
Published in Bioorganic & medicinal chemistry (01-04-2010)“…The total syntheses of natural product rhuschalcone VI and eight analogs employing the Suzuki–Miyaura reaction are reported together with antiprotozoal…”
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Antimicrobial activities of the methanol extract and compounds from Artocarpus communis (Moraceae)
Published in BMC complementary and alternative medicine (25-05-2011)“…Artocarpus communis is used traditionally in Cameroon to treat several ailments, including infectious and associated diseases. This work was therefore designed…”
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Old plants newly discovered: Cassia sieberiana D.C. and Cassia abbreviata Oliv. Oliv. root extracts inhibit in vitro HIV-1c replication in peripheral blood mononuclear cells (PBMCs) by different modes of action
Published in Journal of ethnopharmacology (07-05-2012)“…Ethanolic extracts from Cassia sieberiana roots (Csr) used by the traditional healer Amos Namushe for HIV/AIDS management in Botswana protect peripheral blood…”
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10
Revision of the Absolute Configuration of Plumericin and Isoplumericin from Plumeria rubra
Published in Chemistry & biodiversity (01-06-2005)“…The absolute configurations of plumericin (1) and isoplumericin (2), isolated from Plumeria rubra, were re‐assigned based on a combination of X‐ray…”
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11
Epunctanone, a New Benzophenone, and Further Secondary Metabolites from Garcinia epunctata Stapf (Guttiferae)
Published in Helvetica chimica acta (01-07-2014)“…A new polyprenylated benzophenone, named epunctanone (1), was isolated from the stem bark of Garcinia epunctata Stapf, together with eight known compounds,…”
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12
Prenylated arylbenzofuran derivatives from Morus mesozygia with antioxidant activity
Published in Phytochemistry (Oxford) (2009)“…Five prenylated arylbenzofurans, moracin Q–U, were isolated from Morus mesozygia (Moraceae). Their structures were elucidated on the basis of spectroscopic…”
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13
Donellanic acids A–C: new cyclopropanic oleanane derivatives from Donella ubanguiensis (Sapotaceae)
Published in Tetrahedron (17-06-2012)“…Three new cyclopropanic oleanane triterpenoids and ten known compounds were obtained from Donella ubanguiensis using chromatographic methods. The structures…”
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Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata
Published in Planta medica (2001)“…The roots of B. capitata yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-c]furan-4,9-dione,…”
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15
Elatumic Acid: A New Ursolic Acid Congener from Omphalocarpum elatum Miers (Sapotaceae)
Published in Zeitschrift für Naturforschung C. A journal of biosciences (01-07-2014)“…A new triterpene diastereomer, 1, of the previously reported 3β,6β,19α-trihydroxy-urs-12-en- 28-oic acid-24-carboxylic acid methyl ester was obtained from the…”
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Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae)
Published in Journal of ethnopharmacology (25-07-2007)“…The crude extract from Treculia obovoidea was subjected to purification by repeated chromatography. Eight compounds were isolated from Treculia obovoidea and…”
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Phosphodiesterase I-inhibiting Diels-Alder adducts from the leaves of Morus mesozygia
Published in Planta medica (01-01-2012)“…A new 2-arylbenzofuran derivative, (+)-dimethylsmoracin O (1), and three new Diels-Alder type adducts, mesozygins A–C (2–4), in addition to eight known…”
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Duboscic Acid: A Potent α-Glucosidase Inhibitor with an Unprecedented Triterpenoidal Carbon Skeleton from Duboscia macrocarpa
Published in Organic letters (17-12-2010)“…Duboscic acid (1), a triterpenoid with a unique carbon backbone, was isolated from Duboscia macrocarpa Bocq. It is the first member of a new class of…”
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Ent-kaurene and ent-beyerene diterpenoids and other constituents of Thecacoris batesii
Published in Bulletin of the Chemical Society of Ethiopia (01-04-2007)“…Two novel diterpenoids, thecacorins A (1) and B (2), were isolated from Thecacoris batesii and their structures were established as…”
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Excelsoside: A New Benzylic Diglycoside from the Leaves of Milicia excelsa
Published in Zeitschrift für Naturforschung C. A journal of biosciences (01-07-2014)“…A new benzylic diglycoside was isolated from the leaves of Milicia excelsa and identified as 3,4-dimethoxybenzyl ß-D-xylopyranosyl(1 2)-ß-D-glucopyranoside…”
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