Search Results - "Bergui, Luciana"

CD38 at the junction between prognostic marker and therapeutic target by Deaglio, Silvia, Aydin, Semra, Vaisitti, Tiziana, Bergui, Luciana, Malavasi, Fabio

“…CD38 is an ectoenzyme involved in transmembrane signaling and cell adhesion and is used as a disease marker for leukemias and myeloma. CD38 is a dependable…”
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CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells by Deaglio, Silvia, Aydin, Semra, Grand, Maurizia Mello, Vaisitti, Tiziana, Bergui, Luciana, D'Arena, Giovanni, Chiorino, Giovanna, Malavasi, Fabio

“…Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor…”
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CD38/CD19: a lipid raft–dependent signaling complex in human B cells by Deaglio, Silvia, Vaisitti, Tiziana, Billington, Richard, Bergui, Luciana, Omede', Paola, Genazzani, Armando A., Malavasi, Fabio

“…The present work deals with the mechanisms of signal transduction mediated via CD38 in normal and neoplastic human B lymphocytes. The results indicate that…”
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CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival by Deaglio, Silvia, Vaisitti, Tiziana, Bergui, Luciana, Bonello, Lisa, Horenstein, Alberto L., Tamagnone, Luca, Boumsell, Laurence, Malavasi, Fabio

“…This work addresses the question whether CD38, a negative prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL), plays a role in neoplastic B-cell…”
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CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? by Aydin, Semra, Rossi, Davide, Bergui, Luciana, D'Arena, Giovanni, Ferrero, Enza, Bonello, Lisa, Omedé, Paola, Novero, Domenico, Morabito, Fortunato, Carbone, Antonino, Gaidano, Gianluca, Malavasi, Fabio, Deaglio, Silvia

“…CD38 rules proliferation signals in chronic lymphocytic leukemia (CLL) cells, suggesting that the molecule is not merely a prognostic marker but also a key…”
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CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells by Deaglio, Silvia, Capobianco, Andrea, Bergui, Luciana, Dürig, Jan, Morabito, Fortunato, Dührsen, Ulrich, Malavasi, Fabio

“…The prognosis for patients with B-cell chronic lymphocytic leukemia (B-CLL) is generally less favorable for those expressing CD38. Our working hypothesis is…”
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CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential by Deaglio, Silvia, Vaisitti, Tiziana, Aydin, Semra, Bergui, Luciana, D'Arena, Giovanni, Bonello, Lisa, Omedé, Paola, Scatolini, Maria, Jaksic, Ozren, Chiorino, Giovanna, Efremov, Dimitar, Malavasi, Fabio

“…Our interest in chronic lymphocytic leukemia (CLL) derives primarily from the exploitation of human diseases as strategic models for defining the in vivo…”
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CD38 modulates CXCL12-mediated chemotaxis: a novel mechanism in homing of chronic lymphocytic leukemia cells (98.7) by Deaglio, Silvia, Vaisitti, Tiziana, Aydin, Semra, Bergui, Luciana, Rossi, Davide, Bonello, Lisa, Chiorino, Giovanna, Gaidano, Gianluca, Malavasi, Fabio

“…Abstract Human CD38, an ectoenzyme involved in the catabolism of NAD, can also bind the non-substrate ligand CD31, resulting in activation and proliferation of…”
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Progressive Telomere Shortening Is Part of the Natural History of Chronic Lymphocytic Leukemia (CLL) and Impacts Clinical Outcome by Bernocco, Elisa, Rossi, Davide, Genuardi, Elisa, Lobetti-Bodoni, Chiara, Passera, Roberto, Drandi, Daniela, Coscia, Marta, Ruggeri, Marina, Fangazio, Marco, Ghione, Paola, Barbero, Daniela, Mantoan, Barbara, Barbiero, Sara, Zanni, Manuela, Gattei, Valter, Bergui, Luciana, Omedè, Paola, Massaia, Massimo, Boccadoro, Mario, Gaidano, Gianluca, Ladetto, Marco

“…Abstract 2845 Telomere length (TL) at diagnosis has been established as an independent outcome predictor in CLL (Rossi et al Leukemia 2009). However data on TL…”
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Dexamethasone, Cytarabine and Cisplatin or Oxaliplatin Schedule (DHAP or Ox-DHA) Is Effective and Widely Applicable in Chronic Lymphocytic Leukemia and Waldenström Macroglobulinemia by Ruella, Marco, Ricca, Irene, Gueli, Angela, Gottardi, Daniela, Caracciolo, Daniele, Bergui, Luciana, Gavarotti, Paolo, De Crescenzo, Alberto, Farina, Lucia, Corradini, Paolo, Tarella, Corrado

“…Abstract 3434 Poster Board III-322 Fludarabine alone or in combination is considered the standard treatment for Chronic Lymphocytic Leukemia (CLL). A high…”
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CD38 Induces Homing of Chronic Lymphocytic Leukemia Cells to the Lymphoid Organs through a Functional Interplay with CXCR4 by Deaglio, Silvia, Aydin, Semra, Vaisitti, Tiziana, Bergui, Luciana, Rossi, Davide, D'Arena, Giovanni, Bonello, Lisa, Mello Grand, Maurizia, Chiorino, Giovanna, Horenstein, Alberto, Gaidano, Gianluca, Malavasi, Fabio

“…Abstract 2328 Poster Board II-305 Chronic lymphocytic leukemia (CLL) is characterized by the expansion of a monoclonal population of mature B lymphocytes…”
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Dexamethasone, Cytarabine and Cisplatin or Oxaliplatin Schedule (DHAP or Ox-DHA) Is Effective and Widely Applicable in Chronic Lymphocytic Leukemia and Waldenström Macroglobulinemia by Ruella, Marco, Ricca, Irene, Gueli, Angela, Gottardi, Daniela, Caracciolo, Daniele, Bergui, Luciana, Gavarotti, Paolo, De Crescenzo, Alberto, Farina, Lucia, Corradini, Paolo, Tarella, Corrado

“…Abstract Abstract 3434 Poster Board III-322 Introduction Fludarabine alone or in combination is considered the standard treatment for Chronic Lymphocytic…”
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Human CD38 Is a Potential Therapeutic Target for Sekected Chronic Lymphocytic Leukemia cases by Deaglio, Silvia, Aydin, Semra, Vaisitti, Tiziana, Bergui, Luciana, D'Arena, Giovanni, Bonello, Lisa, Saborit, Ifigenia, Rossi, Davide, Gaidano, Gianluca, Chiorino, Giovanna, Malavasi, Fabio

“…Chronic lymphocytic leukemia (CLL), the most common leukemia in Europe and North America, is characterized by a highly heterogeneous clinical behavior. Absence…”
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Non-Hodgkin's Lymphoma Refractory to First Line Therapy: Incidence, Associated Clinical and Histological Factors, and Outcome among 503 Newly Diagnosed Patients by Gueli, Angela, Caracciolo, Daniele, Zanni, Manuela, Bergui, Luciana, Gavarotti, Paolo, Ladetto, Marco, Filippi, Andrea, Passera, Roberto, Boccadoro, Mario, Tarella, Corrado

“…Introduction: Non-Hodgkin's lymphoma (NHL) are malignancies usually sensitive to chemotherapy; this results in prolonged survival and often disease eradication…”
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CD38 and ZAP-70 Mark Chronic Lymphocytic Leukemia (CLL) Cells with High Migratory Potential and Regulate Chemotaxis by Deaglio, Silvia, Aydin, Semra, Vaisitti, Tiziana, Bergui, Luciana, D'Arena, Giovanni, Bonello, Lisa, Omedé, Paola, Chiorino, Giovanna, Efremov, Dimitar, Malavasi, Fabio

“…The absence of mutations in the IgVH genes along with the expression of the cell surface receptor CD38 and the cytoplasmic kinase ZAP-70 are independent…”
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CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential. Commentary by BURGER, Jan A, DEAGLIO, Silvia, CHIORINO, Giovanna, EFREMOV, Dimitar, MALAVASI, Fabio, VAISITTI, Tiziana, AYDIN, Semra, BERGUI, Luciana, D'ARENA, Giovanni, BONELLO, Lisa, OMEDE, Paola, SCATOLINI, Maria, JAKSIC, Ozren

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Telomere Length Is An Independent Predictor of Survival, Treatment Requirement and Richter's Syndrome Transformation in Chronic Lymphocytic Leukemia by Rossi, Davide, Bodoni, Chiara Lobetti, Genuardi, Elisa, Monitillo, Luigia, Drandi, Daniela, Deambrogi, Clara, Cerri, Michaela, Ricca, Irene, Rocci, Alberto, Ferrero, Simone, Bernocco, Elisa, Capello, Daniela, De Paoli, Lorenzo, Bergui, Luciana, Boi, Michela, Omedè, Paola, Massaia, Massimo, Tarella, Corrado, Passera, Roberto, Boccadoro, Mario, Gaidano, Gianluca, Ladetto, Marco

“…Background and aims. In CLL, TL has been associated to outcome. However a larger patient sample and an analysis on a blinded validation series are required to…”
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Incidence and Risk-Factors of Secondary Myelodysplastic Syndrome/Acute Leukemia Following High-Dose Chemotherapy and Autograft: A Long-Term Analysis on 307 Lymphoma Patients by Bono, Davide, Zanni, Manuela, Ricca, Irene, Caracciolo, Daniele, Dama, Elisa, Magnani, Corrado, Gavarotti, Paolo, Bergui, Luciana, Cuttica, Alessandra, Ladetto, Marco, Boccadoro, Mario, Ferrero, Dario, Tarella, Corrado

“…INTRODUCTION High-dose chemotherapy (HDT) with autologous stem cell transplantation is an effective treatment option for both non-Hodgkin's Lymphoma (NHL) and…”
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Telomere Length Identifies Two Distinct Populations with Different Outcome among VH-Unmutated CLL Patients by Ricca, Irene, Rocci, Alberto, Drandi, Daniela, Compagno, Mara, Francese, Roberto, Omedè, Paola, Santo, Loredana, Rosace, Michela, De Marco, Federica, Astolfi, Monica, Bodoni, Chiara Lobetti, Dell'Aquila, Maria, Vallet, Sonia, Bergui, Luciana, Gallamini, Andrea, Marinone, Carlo, Boccadoro, Mario, Tarella, Corrado, Ladetto, Marco

“…Introduction Telomere restriction fragments (TRF) length is a well-known prognostic indicator in CLL. Long telomeres have been associated with VH-mutated…”
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Telomere Length Has Prognostic Impact in B-Cell Chronic Lymphocytic Leukemia (B-CLL) by Ricca, Irene, Drandi, Daniela, Rocci, Alberto, Compagno, Mara, Francese, Roberto, Mantoan, Barbara, Castellino, Claudia, Ficara, Francesca, Vallet, Sonia, Dell'Aquila, Maria, Santo, Loredana, Caracciolo, Daniele, Bergui, Luciana, Gallamini, Andrea, Bazzan, Mario, Marinone, Carlo, Boccadoro, Mario, Tarella, Corrado, Ladetto, Marco

“…BACKGROUND. Germinal Center (GC) experience is a basic prognostic feature in B-CLL. Patients with VH-mutated GC-experienced CLL have a good prognosis while…”
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