Search Results - "Bergseth, Grethe"

An international serum standard for application in assays to detect human complement activation products by Bergseth, Grethe, Ludviksen, Judith K., Kirschfink, Michael, Giclas, Patricia C., Nilsson, Bo, Mollnes, Tom E.

“…The importance of the complement system in clinical medicine has become evident during the last decades and complement therapeutics has now reached the clinic…”
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Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature by Lappegård, Knut Tore, Christiansen, Dorte, Pharo, Anne, Thorgersen, Ebbe Billmann, Hellerud, Bernt Christian, Lindstad, Julie, Nielsen, Erik Waage, Bergseth, Grethe, Fadnes, Dag, Abrahamsen, Tore G, Høiby, E. Arne, Schejbel, Lone, Garred, Peter, Lambris, John D, Harboe, Morten, Mollnes, Tom Eirik

“…Complement component C5 is crucial for experimental animal inflammatory tissue damage; however, its involvement in human inflammation is incompletely…”
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NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies by Lau, Corinna, McAdam, Martin Berner, Bergseth, Grethe, Grevys, Algirdas, Bruun, Jack Ansgar, Ludviksen, Judith Krey, Fure, Hilde, Espevik, Terje, Moen, Anders, Andersen, Jan Terje, Mollnes, Tom Eirik

“…The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab…”
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Artificial Surface-Induced Inflammation Relies on Complement Factor 5: Proof From a Deficient Person by Bergseth, Grethe, BS, Lambris, John D., PhD, Mollnes, Tom Eirik, MD, PhD, Lappegård, Knut Tore, MD, PhD

“…Background Exposing blood to artificial surfaces results in an inflammatory response, including complement activation and cytokine release. The aim of this…”
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Clinical and Complement Long-Term Follow-Up of a Pediatric Patient with C3 Mutation-Related Atypical Hemolytic Uremic Syndrome by Mollnes, Tom Eirik, Bosnes, Vidar, Stokke, Arne, Ludviksen, Judith Krey, Bergseth, Grethe, Bjerre, Anna, Karpman, Diana

“…We report a pediatric patient with atypical hemolytic uremic syndrome due to a C3 gain-of-function mutation diagnosed in infancy. She was treated from the…”
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Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report by Gustavsen, Alice, Skattum, Lillemor, Bergseth, Grethe, Lorentzen, Bjorg, Floisand, Yngvar, Bosnes, Vidar, Mollnes, Tom Eirik, Barratt-Due, Andreas

“…Antiphospholipid syndrome (APS) in pregnancy may trigger the life-threatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is…”
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Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome by Gustavsen, Alice, Skattum, Lillemor, Bergseth, Grete, Lorentzen, Bjørg, Fløisand, Yngvar, Bosnes, Vidar, Mollnes, Tom Eirik, Barratt-Due, Andreas

“…Rationale:Antiphospholipid syndrome (APS) in pregnancy may trigger the lifethreatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is…”
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Platelet compatibility of an artificial surface modified with functionally active heparin by Mollnes, T E, Videm, V, Christiansen, D, Bergseth, G, Riesenfeld, J, Hovig, T

“…Platelet compatibility after coating an artificial material with functionally active heparin was investigated. Blood was circulated in uncoated or heparin…”
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A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity by Nilsson, Per H, Johnson, Christina, Quach, Quang Huy, Macpherson, Alex, Durrant, Oliver, Pischke, Soeren E, Fure, Hilde, Landsem, Anne, Bergseth, Grethe, Schjalm, Camilla, Haugaard-Kedström, Linda M, Huber-Lang, Markus, van den Elsen, Jean, Brekke, Ole-Lars, Mollnes, Tom Eirik

“…Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially…”
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Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn by Hallstensen, Randi Fykse, Bergseth, Grethe, Foss, Stian, Jæger, Steinar, Gedde-Dahl, Tobias, Holt, Jan, Christiansen, Dorte, Lau, Corinna, Brekke, Ole-Lars, Armstrong, Elina, Stefanovic, Vedran, Andersen, Jan Terje, Sandlie, Inger, Mollnes, Tom Eirik

“…Abstract Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or…”
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Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome by Barratt-Due, Andreas, Fløisand, Yngvar, Orrem, Hilde L, Kvam, Ann K, Holme, Pål A, Bergseth, Grethe, Tjønnfjord, Geir E, Mollnes, Tom E

“…Catastrophic antiphospholipid syndrome is associated with excessive complement activation explaining the clinical efficacy of complement inhibitory treatment…”
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NHDL, a recombinant V L /V H hybrid antibody control for IgG2/4 antibodies by Lau, Corinna, McAdam, Martin Berner, Bergseth, Grethe, Grevys, Algirdas, Bruun, Jack Ansgar, Ludviksen, Judith Krey, Fure, Hilde, Espevik, Terje, Moen, Anders, Andersen, Jan Terje, Mollnes, Tom Eirik

“…The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab…”
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Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome by Volokhina, Elena B, van de Kar, Nicole C.A.J, Bergseth, Grethe, van der Velden, Thea J.A.M, Westra, Dineke, Wetzels, Jack F.M, van den Heuvel, Lambertus P, Mollnes, Tom Eirik

“…Abstract Complement C5 inhibitor eculizumab treatment in atypical hemolytic uremic syndrome is effective, but associated with high costs. Complement inhibition…”
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Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses by Nilsson, Per H., Thomas, Anub Mathew, Bergseth, Grethe, Gustavsen, Alice, Volokhina, Elena B., van den Heuvel, Lambertus P., Barratt-Due, Andreas, Mollnes, Tom E.

“…•Antibodies to neoepitopes are crucial tools for detection of complement activation.•Changes of complement proteins without activation can expose…”
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Essential role of the C5a receptor in E coli–induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation by Mollnes, Tom Eirik, Brekke, Ole-Lars, Fung, Michael, Fure, Hilde, Christiansen, Dorte, Bergseth, Grethe, Videm, Vibeke, Lappegård, Knut Tore, Köhl, Jörg, Lambris, John D.

“…Complement plays an essential role in inflammation and tissue damage. However, it is largely unknown to what extent the system acts as a primary inducer of…”
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A novel human whole blood model preventing fibrin formation reveals that thrombin does not cleave plasma C5 under physiological conditions by Nilsson, Per H., Johnson, Christina, Pischke, Soeren E., Fure, Hilde, Landsem, Anne, Bergseth, Grethe, Schjalm, Camilla, Haugaard-Kedström, Linda M., Huber-Lang, Markus, Brekke, Ole-Lars, Mollnes, Tom Eirik

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Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo by Volokhina, Elena B., Bergseth, Grethe, van de Kar, NicoleC.A.J., van den Heuvel, Lambertus P., Mollnes, Tom Eirik

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Corrigendum to “An international serum standard for application in assays to detect human complement activation products” [Mol. Immunol. 56 (2013) 232–239] by Bergseth, Grethe, Ludviksen, Judith K., Kirschfink, Michael, Giclas, Patricia C., Nilsson, Bo, Mollnes, Tom E.

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Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5‐deficient individual by Hardersen, Randolf, Enebakk, Terje, Christiansen, Dorte, Bergseth, Grethe, Brekke, Ole‐Lars, Mollnes, Tom Eirik, Lappegård, Knut Tore, Hovland, Anders

“…The aim of the study was to investigate the role of complement factor 5 (C5) in reactions elicited by plasma separation using blood from a C5‐deficient (C5D)…”
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Neoepitope based assays to detect C5a – Pitfalls and interpretations by Bergseth, Grethe, Nilsson, Per H., Thomas, Anub Mathew, Gustavsen, Alice, Volokhina, Elena B., van den Heuvel, Lambertus P., Barratt-Due, Andreas, Mollnes, Tom E.

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